A5100784794- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone Tumor Diagnosis and Treatments
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- PI3K/AKT/mTOR signaling in cancer
- Sarcoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Catalysis for Biomass Conversion
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Retinal and Optic Conditions
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Antimicrobial Peptides and Activities
- Bone health and treatments
- MicroRNA in disease regulation
- Dermatologic Treatments and Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Collagen: Extraction and Characterization
- NF-κB Signaling Pathways
- Heat shock proteins research
- Advanced Breast Cancer Therapies
Beijing University of Chinese Medicine
2018-2025
Wuhan University
2008-2024
Renmin Hospital of Wuhan University
2008-2024
Zhejiang University of Technology
2023-2024
Second Military Medical University
2022-2023
Hangzhou First People's Hospital
2022-2023
Zhejiang University
2022-2023
Harbin Medical University
2023
First Affiliated Hospital of Harbin Medical University
2023
First Affiliated Hospital of Nanchang University
2022
Immune infiltration plays an important role in the course of ischemic stroke (IS) progression. Cuproptosis is a newly discovered form programmed cell death. To date, no studies on mechanisms by which cuproptosis-related genes regulate immune IS have been reported.IS-related microarray datasets were retrieved from Gene Expression Omnibus (GEO) database and standardized. was extracted quantified based processed gene expression matrix. The differences between group normal as well correlation...
Background Idiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease of unknown etiology, remains incurable with current therapies, which fail to halt progression or restore function. However, Feibi Recipe No. 2 (FBR2), a clinically validated traditional Chinese medicine formula, exhibits potential as IPF treatment. Objective This study aimed investigate the regulatory effect FBR2 on ferroptosis through SIRT3/p53 pathway and its therapeutic in improving IPF. Methods fibrosis was...
Calycosin (CA) is a flavonoid extracted from the root of Astragalus membranaceus and has antioxidant, anti-inflammation, antiapoptosis properties. The objective this study was to investigate efficacy CA in protecting against pulmonary fibrosis. (14 mg/kg) SB216763 (20 were administrated bleomycin-induced fibrosis mice for 3 weeks. results concluded that alleviated inflammation collagen deposition In addition, reduced MDA level, enhanced SOD TAC activities, increased activity Nrf2/HO-1...
Reactive oxygen species (ROS)-mediated alveolar epithelial cell (AEC) injury and apoptosis are considered to be the initiating link of idiopathic pulmonary fibrosis (IPF), protecting AECs can alleviate IPF. This study aimed explore protective effect number 2 Feibi recipe (FBR-2) medicated serum on H O -mediated oxidative stress in further its mechanism. We found that FBR-2 regulate downstream antioxidant enzymes expression by activating nuclear factor erythroid 2-related (Nrf2), reducing...
Esterase/lipase-catalyzed selective hydrolysis of d , l -menthyl esters has become one the promising approaches for producing -menthol, most important flavoring chemicals with extensive uses.
Number 2 Feibi Recipe (N2FBR) is a traditional Chinese medicine formula for treating idiopathic pulmonary fibrosis. N2FBR inhibits H2O2-mediated oxidative stress damage in alveolar epithelial cells by increasing autophagy, as we previously demonstrated. However, it unknown if similar mechanisms occur vivo. We established fibrosis model instilling bleomycin (BLM) from the airway to examine effects of on and investigate its probable mechanism this work. discovered that treatment effectively...
Abstract Accurate recognition of surface water bodies is important for disaster management and resource planning. To explore a higher-precision body method, propose an improved channel attention mechanism UNet (ECA-UNet) model based on Sentinel-2A remote sensing images. Utilizing ECA-UNet, UNet, PSPnet, DeeplabV3, as well the traditional normalized index ( NDWI ), recognize in Taihu Lake area. Through comparative analysis, following main conclusions are drawn: (1) The accuracy deep learning...
To initially explore traditional Chinese medicine patterns in a bleomycin-induced pulmonary fibrosis mouse model. Thirty-six C57BL/6 mice were divided by the random number table method (with 12 rats per group) into three groups: blank group, model and 2 Feibi recipe (FBR-2) group. The was established intratracheal instillation of bleomycin. FBR-2 group treated with for 4 weeks. Symptoms such as mental behavior, food/water intake, body weight, temperature, respiratory rate, tongue image...
Osteosarcoma (OS) is a primary malignant tumor of the bone characterized by poor prognosis due to chemotherapy resistance and high recurrence rates. DJ-1 (PARK7) known as an oncogene its abnormal expression related various types tumors. It was found in this study that upregulated closely correlated with OS patients promoting proliferation, migration cells vitro through regulating activity CDK4 but not oxidation mechanism or AKT pathway. The combination promoted RB phosphorylation, leading...
To assess the efficacy and safety in 105 patients with seasonal Influenza Beijing, mixture prepared Chinese medicines follows treatment regimen of releasing exterior cold clearing interior heat.Total 330 influenza were enrolled randomly averagely divided into herbal medicine, western medicine patent group. They treated Oseltamivir Phosphate Capsules Scattering Wind Resolving Toxins Capsules. The main indicators antifebrile onset time recovery body temperature. was scientifically evaluated....
<title>Abstract</title> Lipase is one of the most widely studied and applied biocatalysts. Due to high enzyme leakage rate immobilization method physical adsorption, we propose a new lipase method, which based on combination macroporous resin adsorption organic polymer coating. The immobilized <italic>Candida antarctic</italic> B (CALB@resin-CAB) was prepared by combining with cellulose acetate butyrate coating, its structure characterized various analytic methods. Immobilized for biodiesel...
In this paper, we introduce a neural network-based method to address the high-dimensional dynamic unbalanced optimal transport (UOT) problem. Dynamic UOT focuses on transportation between two densities with unequal total mass, however, it introduces additional complexities compared traditional (OT) To efficiently solve problem in space, first relax original by using generalized Kullback-Leibler (GKL) divergence constrain terminal density. Next, adopt Lagrangian discretization continuity...
Feibi decoction (FBD) is a traditional Chinese herbal medicine and has been clinically used in the treatment of pulmonary fibrosis (PF), which characterized by diffuse interstitial inflammation exaggerated collagen accumulation. However, potential mechanisms remain to be elucidated. The present study aimed investigate effect FBD-medicated serum (FBDS) on lipopolysaccharide (LPS)-induced macrophages. In RAW264.7 macrophages bone marrow-derived (BMDMs), FBDS significantly inhibited production...
Background: Mutations in PRKAR1A gene can lead to Carney complex (CNC), and most CNC patients develop cardiac cutaneous myxomas. In particular, myxomas are a common cause of mortality patients. Cutaneous the external ear extremely rare, do not have any specific clinical features Methods: this retrospective study, we analyzed genetic data proband his family fifty whole blood control samples selected from molecular database our hospital. Whole exome DNA sequencing analysis was used detect...
Lipases are among the most widely studied and applied biocatalysts. A novel lipase immobilization method was developed based on combination of macroporous resin adsorption organic polymer coating. The immobilized Candida antarctic B (CALB@resin-polymer) prepared by combining XRZ04B cellulose acetate butyrate structure characterized various methods. Immobilized to enzyme-catalyzed biodiesel production, conversion rate achieved as high 98.5% in two steps. Furthermore, displayed satisfactory...