A5083062491- Parasitic Infections and Diagnostics
- Coccidia and coccidiosis research
- Helminth infection and control
- Parasitic infections in humans and animals
- Toxoplasma gondii Research Studies
- Animal Nutrition and Physiology
- Veterinary medicine and infectious diseases
- Congenital Anomalies and Fetal Surgery
- Parasite Biology and Host Interactions
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Colorectal Cancer Treatments and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lipid metabolism and disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Parasites and Host Interactions
- Aquaculture disease management and microbiota
- Respiratory Support and Mechanisms
- Sirtuins and Resveratrol in Medicine
- Neurological Disease Mechanisms and Treatments
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
Guangxi University
2022-2025
Guangxi Veterinary Research Institute
2022-2025
Chongqing Dazu District People's Hospital
2025
Chongqing Medical University
2025
Central South University of Forestry and Technology
2025
Chengdu Women's and Children's Central Hospital
2025
Academy of State Administration of Grain
2025
Central South University
2025
Guangxi Center for Disease Prevention and Control
2022-2024
Zhejiang University
2011-2024
Abstract Coccidiosis, an intestinal disease caused by Eimeria protozoan parasites, affects various animal species, and especially poses a significant threat to the poultry industry. The current primary control methods include anticoccidial drugs vaccines. However, emerging challenges such as drug resistance vaccine efficacy issues are rooted in complex life cycle species diversification of . In this review, we first consolidate recent breakthroughs understanding biology, focusing on parasite...
The apicomplexan parasites Eimeria spp. are the causative agents of coccidiosis, a disease with significant global impact on poultry industry. complex life cycle involves exogenous (sporogony) and endogenous (schizogony gametogony) stages. Unfortunately, genetic regulation these highly dynamic processes, particularly for genes involved in specific developmental phases, is not well understood.
Coccidiosis is one of the most serious diseases livestock and birds in world. Vaccination with live-parasite anticoccidial vaccines genetic manipulation improving immunogenicity vaccine strains would be best means for controlling coccidiosis breeder layer stocks, even fast-growing broilers. Profilin from apicomplexan parasites first molecularly defined ligand Toll-like receptor 11 (TLR11) TLR12 mice a potential molecular adjuvant. Here, we constructed transgenic Eimeria tenella line...
Intestinal coccidiosis is a common parasitic disease in livestock, caused by the infection of Eimeria and Cystoisospora parasites, which results great economic losses to animal husbandry. Triazine compounds, such as toltrazuril diclazuril, are widely used treatment chemoprophylaxis coccidiosis. Unfortunately, widespread drug resistance has compromised their effectiveness. Most studies have focused on prophylaxis therapeutics with flocks, while comprehensive understanding how alters...
Coccidiosis, which is caused by Eimeria species, results in huge economic losses to the poultry industry. Arbor Acres (AA) broilers and yellow-feathered are dominant northern southern China, respectively. However, their susceptibility coccidiosis has not been fully compared. In this study, of broilers, AA Lohmann pink layers E. tenella was evaluated based on mortality rate, relative body weight gain intestinal lesion score, oocyst output, anticoccidial index (ACI), cecum length. The were...
Toxoplasma gondii is an intracellular parasite that important in medicine and veterinary science undergoes distinct developmental transitions its intermediate definitive hosts. The switch between stages of T. meticulously regulated by a variety factors. Previous studies have explored the role microrchidia (MORC) protein complex as transcriptional suppressor sexual commitment. By utilizing immunoprecipitation mass spectrometry, constituents this been identified, including MORC, Histone...
The control of coccidiosis, causing huge economic losses in the poultry industry, is facing stagnation development new drugs and emergence drug resistance. Thus, priority for coccidiosis to decipher effect mechanisms resistance anticoccidial drugs. In this study, we mined validated a molecular marker halofuginone Eimeria tenella through forward reverse genetic approaches. We screened whole-genome sequencing data detected point mutations ETH2_1020900 gene (encoding prolyl-tRNA synthetase,...
Worldwide distributed coccidiosis is caused by infection of both Eimeria species and Cystoisospora in the host intestine causes huge economic losses to livestock industry, especially poultry industry. The control such diseases relies mainly on chemoprophylaxis with anticoccidials, which has led a very common drug resistance this field. However, genetic mechanisms underlying many anticoccidial drugs remain unknown. In study, strains E. tenella resistant 250 mg/kg monensin were generated...
Magnolol, a natural extract from magnolia officinalis, has received growing interest of its bioactive properties such as antioxidant, anti-inflammatory, and antibacterial activities. Nevertheless, there is little research on Magnolol in the treatment parasitic infections currently. Eimeria tenella (E. tenella) infection causes damage to epithelial cells cecal mucosa, resulting increased intestinal permeability, which pretty detrimental balance microenvironment. However, at present, chicken...
Our study aim is to explore the mechanisms of short peptide passages on intestinal dysfunction in septic mice utilizing a metabolomics approach, which provides new scientific basis for clinical sepsis. Mices were allocated at random into four groups: control (Con), cecal ligation and puncture followed by one, three or 7 day short-peptide-based enteral nutrition group (CLP + SPEN1), SPEN3), SPEN7) groups. A liquid chromatography-mass spectrometry-based method was used analyze changes serum...
Background/Objectives: Lactobacillus strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). The aim of this study was to investigate effects dietary supplementation with microencapsulated plantarum 17-1 on intestinal immune response gut microbiota mice colitis. Methods: Mice were pre-fed a diet containing three weeks, followed by colitis induction using 2.5% dextran sulfate sodium (DSS) drinking water 8 days....
Abstract The apicomplexan parasite Eimeria is the causative agent of coccidiosis, which results in enteritis animals and imposes a significant economic burden on farming industry. Apicomplexan Apetala2/ERF (ApiAP2) transcription factors are known to play crucial roles various processes Apicomplexa parasites. However, little understood regarding role ApiAP2s species. In this study, we performed functional characterisation ApiAP2 through CRISPR-Cas9-mediated knockout. Our revealed that...
Toxoplasma gondii, an obligate intracellular protozoan parasite infecting nucleated cells of warm-blooded vertebrates, causes severe complications in immunocompromised hosts. Current therapies remain limited by suboptimal efficacy and toxicity, necessitating novel anti-toxoplasmic agents. Piceatannol (PIC), a natural stilbenoid, demonstrates multifaceted bioactivity including antimicrobial anti-parasitic effects, suggesting therapeutic potential against T. gondii. Our previous study revealed...
Eimeria species are pathogenic protozoa with a wide range of hosts and the cause poultry coccidiosis, which results in huge economic losses to industry. These parasites encode genome ∼8000 genes that control highly coordinated life cycle asexual replication sexual differentiation, transmission, virulence. However, function physiological importance large majority these remain unknown mostly due lack tools for systematic analysis gene functions. Here, we report first application CRISPR-Cas9...
is an intracellular parasitic protozoan that poses a significant risk to the fetus carried by pregnant woman or immunocompromised individuals.
Necrotic enteritis (NE), caused by
Background/Objectives: Lactobacillus strains are widely used as probiotics in the functional food industry and show potential for treating inflammatory bowel disease (IBD). However, strain specificity limited stress resistance of restricts its therapeutic effectiveness. The aim this study was to investigate effects dietary supplementation with microencapsulated plantarum 17-1 on intestinal immune responses, gut microbiota composition, metabolic characteristics colitis mice. Methods: Mice...
Cystic echinococcosis (hydatid disease), caused by the tapeworm Echinococcus granulosus (class Cestoda; family Taeniidae), is a neglected tropical disease that results in morbidity and mortality millions of humans, as well huge economic losses livestock industry globally. Proteins from tetraspanin parasites have recently become regarded crucial molecules interaction with hosts parasitism are therefore suitable for development vaccines diagnostic agents. However, no information available to...
Eimeria parasites are the causative agents of coccidiosis, a common parasitic disease in poultry and livestock that causes significant economic losses to animal husbandry industry. Ionophore coccidiostats, such as monensin salinomycin, widely used for prophylaxis coccidiosis poultry. Unfortunately, widespread drug resistance has compromised their efficacy. As result, there is an increasing need understand targets mechanisms anticoccidials. However, how parasite genes respond ionophores...
Protozoan parasites of the genus Eimeria are causative agents chicken coccidiosis. Parasite resistance to most anticoccidial drugs is one major challenges controlling this disease. There an urgent need for a molecular marker monitor emergence against drugs, such as decoquinate.We developed decoquinate-resistant strains by successively exposing Houghton (H) and Xinjiang (XJ) E. tenella incremental concentrations drug in chickens. Additionally, we isolated strain from field. The these three...
Echinococcus granulosus is the causative agent of cystic echinococcosis with medical and veterinary importance in China. Our main objective was to discuss genotypes genetic diversity E. present domestic animals humans western A total 45 hydatid cyst samples were collected from sheep, humans, a yak subjected an analysis sequences mitochondrial cytochrome b (cytb) gene. The amplified PCR product for all 1,068 bp band. phylogenetic showed that identified as (genotype G1). Ten haplotypes...