A5100328549- Effects and risks of endocrine disrupting chemicals
- Cancer Genomics and Diagnostics
- Sperm and Testicular Function
- Toxic Organic Pollutants Impact
- Water Treatment and Disinfection
- Cancer Cells and Metastasis
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- BRCA gene mutations in cancer
- Heavy Metal Exposure and Toxicity
- Breast Cancer Treatment Studies
- Air Quality and Health Impacts
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Gestational Diabetes Research and Management
- Bioinformatics and Genomic Networks
- Hormonal and reproductive studies
- Ovarian function and disorders
- Reproductive Health and Technologies
- Sexual function and dysfunction studies
- Carcinogens and Genotoxicity Assessment
- Chemical Analysis and Environmental Impact
- Selenium in Biological Systems
Harvard University
1997-2025
University of Wisconsin–Madison
2022-2025
Southwest University
2019-2025
Third Affiliated Hospital of Zhengzhou University
2024-2025
Shanghai Jiao Tong University
2009-2025
Sichuan University
2023-2025
Chongqing Medical University
2025
University of Birmingham
2019-2025
Second Military Medical University
2010-2025
China Agricultural University
2024-2025
Abstract Purpose: Recently, a 76-gene prognostic signature able to predict distant metastases in lymph node–negative (N−) breast cancer patients was reported. The aims of this study conducted by TRANSBIG were independently validate these results and compare the outcome with clinical risk assessment. Experimental Design: Gene expression profiling frozen samples from 198 N− systemically untreated done at Bordet Institute, blinded data independent Veridex. Genomic defined Veridex, data....
Purpose Breast cancer arising in young women is correlated with inferior survival and higher incidence of negative clinicopathologic features. The biology driving this aggressive disease has yet to be defined. Patients Methods Clinically annotated, microarray data from 784 early-stage breast cancers were identified, prospectively defined, age-specific cohorts (young: ≤ 45 years, n = 200; older: ≥ 65 211) compared by prognosis, variables, mRNA expression values, single-gene analysis, gene set...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted person to and, months, has caused more than 82 000 laboratory-confirmed cases of disease 2019 (COVID-19) and 2800 deaths 46 countries. The total number surpassed that the 2003 severe (SARS-CoV). Although both COVID-19 (SARS) manifest as pneumonia, associated with apparently efficient transmission, fewer diarrhoea, increased mental confusion, a lower...
Abstract We explored whether the five previously reported molecular subtypes in breast cancer show a preference for organ-specific relapse and searched pathways involved. The “intrinsic” gene list describing was used to classify 344 primary tumors of lymph node–negative patients. Fisher exact tests were determine association between tumor subtype particular site distant these patients who only received local treatment. Modulated genes identified various groups using Significance Analysis...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging that has resulted in more than 000 laboratory-confirmed cases including over 145 deaths. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, appears to be highly efficient person-to-person transmission frequently causes asymptomatic or presymptomatic infections. However, the underlying mechanisms confer these viral characteristics high transmissibility infection...
Abstract Purpose: Cutaneous melanoma is a common, aggressive cancer with increasing incidence. The identification of melanoma-specific deregulated genes could provide molecular markers for lymph node staging assays and further insight into tumorigenesis. Experimental Design: Total RNA isolated from 45 primary melanoma, 18 benign skin nevi, 7 normal tissue specimens were analyzed on an Affymetrix Hu133A microarray containing 22,000 probe sets. Results: Hierarchical clustering revealed...
The 5-year survival rate of patients with Dukes' B colon cancer is approximately 75%. Identification the at high risk recurrence in this group would allow better staging and more informed use adjuvant chemotherapy. In study, we used DNA chip technology to systematically identify new prognostic markers for tumor relapse patients.Using Affymetrix U133a GeneChip containing 22,000 transcripts (Affymetrix, Santa Clara, CA), RNA samples from 74 were analyzed. Thirty-one developed less than 3...
The association between large tumor size and metastatic risk in a majority of clinical cancers has led to questions as whether these observations are causally related or one is simply marker for the other. This partly due an uncertainty about how metastasis-promoting gene expression changes can arise primary tumors. We investigated this question through analysis previously defined "lung metastasis gene-expression signature" (LMS) that mediates experimental breast cancer selectively lung...
We previously identified in a single-center study 76-gene prognostic signature for lymph node-negative (LNN) breast cancer patients. The aim of this was to validate gene an independent more diverse population LNN patients from multiple institutions.Using custom-designed DNA chips we analyzed the expression 76 genes RNA frozen tumor samples 180 who did not receive adjuvant systemic treatment.In validation, highly informative identifying with distant metastasis within 5 years (hazard ratio,...
The biology of tumors relapsing to bone is poorly understood. In this study, we initiated a search for genes that are implicated in breast cancer.We analyzed 107 primary patients who were all lymph node negative at the time diagnosis and had experienced relapse. Total RNA isolated from frozen tumor samples was used gather gene expression data using oligo microarrays.A panel 69 found significantly differentially expressed between relapse versus those elsewhere body. most gene, TFF1, confirmed...
Coronavirus tropism is predominantly determined by the interaction between coronavirus spikes and host receptors. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Spikes from highly related can recognize distinct receptors, whereas of distant employ same cell-surface molecule for entry. Moreover, broad range molecules in addition to receptors thereby augment attachment or The receptor Middle East respiratory syndrome...
Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. Dendritic cells macrophages are sentinel for innate adaptive immunity that affect the pathogenesis severe acute syndrome (SARS) Middle East (MERS). The interplay between SARS-CoV-2 these cell types remains unknown. We investigated infection host responses monocyte-derived dendritic (moDCs) (MDMs) infected by...
Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike that has been suggested associate with an increased recognition of mouse ACE2, raising the postulation these variants may have evolved expand species tropism wildtype potentially other murines. Our study evaluated this possibility substantial public health importance.
To evaluate whether irregular or long menstrual cycles throughout the life course are associated with all cause and specific premature mortality (age <70 years).Prospective cohort study.Nurses' Health Study II (1993-2017).79 505 premenopausal women without a history of cardiovascular disease, cancer, diabetes who reported usual length regularity their at ages 14-17 years, 18-22 29-46 years.Hazard ratios 95% confidence intervals for (death before age 70 years) were estimated from...
Abstract Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on transmissibility and pathogenesis, reveal targets intervention. Here, we analyze host viral determinants essential for in both lung epithelial ex vivo tissues. We identify heparan sulfate as an important attachment factor infection. Next, show sialic acids present ACE2 prevent spike/ACE2-interaction. While SARS-CoV is substantially limited by acid-mediated restriction...
Importance Tongxinluo, a traditional Chinese medicine compound, has shown promise in vitro, animal, and small human studies for myocardial infarction, but not been rigorously evaluated large randomized clinical trials. Objective To investigate whether Tongxinluo could improve outcomes patients with ST-segment elevation infarction (STEMI). Design, Setting, Participants Randomized, double-blind, placebo-controlled trial was conducted among STEMI within 24 hours of symptom onset from 124...
Purpose To evaluate the feasibility of a 10-gene reverse transcriptase polymerase chain reaction assay to identify tissue origin in patients with carcinoma unknown primary (CUP) site. Patients and Methods Diagnostic biopsy formalin-fixed, paraffin-embedded (FFPE) specimens from 120 CUP were collected retrospectively Sarah Cannon Research Institute, Nashville, TN, prospectively The University Texas M. D. Anderson Cancer Center, Houston, TX. Tissue assignments by correlated clinical pathologic...
Abstract Purpose: Molecular characterization of circulating tumor cells (CTC) holds great promise. Unfortunately, routinely isolated CTC fractions currently still contain contaminating leukocytes, which makes CTC-specific molecular extremely challenging. In this study, we determined mRNA and microRNA (miRNA) expression potentially genes that are considered to be clinically relevant in breast cancer. Experimental Design: CTCs were with the epithelial cell adhesion molecule–based CellSearch...
Although anti‐EGFR therapy has established efficacy in metastatic colorectal cancer, only 10‐20% of unselected patients respond. This is partly due to KRAS and BRAF mutations, which are currently assessed the primary tumor. To improve patient selection, assessing mutation status circulating tumor cells (CTCs), possibly better represent metastases than tumor, could be advantageous. We investigated feasibility detection CTCs by comparing three sensitive methods compared matching liver...
By conjugating carbazole moiety to the different positions of rigid skeleton 1,2-diphenyl-1H-phenanthro[9,10-d]imidazole, a series hybrid bipolar phosphorescent hosts was synthesized, and their photophysical properties were investigated. The introduction phenanthroimidazole greatly improves morphological stability, with high decomposition temperatures (Td) glass transition (Tg) in range 394–417 113–243 °C, respectively. highly efficient green orange organic light-emitting diodes (PhOLEDs)...