A5100436142- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Protein Degradation and Inhibitors
- Sleep and Wakefulness Research
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Sleep and related disorders
- Histone Deacetylase Inhibitors Research
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Click Chemistry and Applications
- Regulation of Appetite and Obesity
- Obstructive Sleep Apnea Research
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- Nuclear Receptors and Signaling
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Infant Health and Development
- Estrogen and related hormone effects
- Evolutionary Psychology and Human Behavior
Anhui Medical University
2025
University of Florida
2013-2024
Broad Institute
2022-2024
Florida College
2021-2024
Jiangnan University
2024
Chinese Institute for Brain Research
2023
State Forestry and Grassland Administration
2023
Gansu Agricultural University
2023
Stanley Center for Psychiatric Research
2022
Center for Excellence in Brain Science and Intelligence Technology
2019-2020
The mesolimbic dopamine (DA) circuitry determines which behaviors are positively reinforcing and therefore should be encoded in the memory to become a part of behavioral repertoire. Natural reinforcers, like food sex, activate this pathway, thereby increasing likelihood further consummatory, social, sexual behaviors. Oxytocin (OT) has been implicated mediating natural reward OT-synthesizing neurons project ventral tegmental area (VTA) nucleus accumbens (NAc); however, direct neuroanatomical...
Stress elicits neuroendocrine, autonomic, and behavioral responses that mitigate homeostatic imbalance ensure survival. However, chronic engagement of such promotes psychological, cardiovascular, metabolic impairments. In recent years, the renin-angiotensin system has emerged as a key mediator stress responding its related pathologies, but neuronal circuits orchestrate these interactions are not known. These studies combine use Cre-recombinase/loxP in mice with optogenetics to structurally...
Obesity is associated with increased levels of angiotensin-II (Ang-II), which activates angiotensin type 1a receptors (AT ) to influence cardiovascular function and energy homeostasis. To test the hypothesis that specific AT within brain control these processes, we used Cre/lox system delete from paraventricular nucleus hypothalamus (PVN) mice. PVN deletion did not affect body mass or adiposity when mice were maintained on standard chow. However, maintenance a high-fat diet revealed gene by...
Despite being innate, displays of aggression are influenced by cortical activities. Here, using Vglut1 as a marker for inputs from structures, we identify small population excitatory neurons located in the posterior amygdala (PA) that project to ventrolateral division ventromedial nucleus hypothalamus (VMHvl), region critically regulates territorial aggression. Indeed, activities PA Vglut1+ (PAVglut1) neurons, analyzed post hoc c-Fos expression, differentiate trials which attacks occur, or...
Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 72 schizophrenia (SCZ) 58 controls, confirmed a marked reduction spindle density SCZ extended these findings show that fast slow properties were...
Activation of corticotropin-releasing hormone (CRH) type 2 receptors (CRHR2) in the nucleus solitary tract (NTS) contributes to development hypertension, but source CRH inputs NTS that increases blood pressure remains unknown. This study tested hypothesis activation CRH-containing projections from paraventricular hypothalamus (PVN) increase pressure. We expressed channelrhodopsin (ChR2), a light-sensitive ion channel, into neurons PVN. was achieved by injecting Cre-inducible virus expressing...
Abstract Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular characterizations. This study presents key immune cell subsets their interactions in the periphery childhood disease. Here we show that single-cell RNA sequencing identifies IFN gene-enriched monocytes, CD4 + T effector memory, XCL1 NK cells as potential players disease, especially those with recurrent parotitis, which is chief symptom prompting clinical visits...
It is known that angiotensin-II acts at its type-1 receptor to stimulate vasopressin (AVP) secretion, which may contribute angiotensin-II-induced hypertension. Less well the impact of angiotensin type-2 (AT2R) activation on these processes. Studies conducted in a transgenic AT2R enhanced green fluorescent protein reporter mouse revealed although are not themselves localized AVP neurons within paraventricular nucleus hypothalamus (PVN), they extend processes into PVN. In present set studies,...
This study tested the hypothesis that deletion of angiotensin type 1a receptors (AT ) from paraventricular nucleus hypothalamus (PVN) attenuates anxiety-like behavior, hypothalamic-pituitary-adrenal (HPA) axis activity, and cardiovascular reactivity. We used Cre/LoxP system to generate male mice with AT specifically deleted PVN. Deletion PVN reduced behavior as indicated by increased time spent in open arms elevated plus maze. In contrast, had no effect on HPA activation subsequent an acute...
Recent evidence suggests hypertension may be secondary to chronic inflammation that results from hypoactive neuro-immune regulatory mechanisms. To further understand this association, we used systemic lupus erythematosus (SLE) as a model of inflammation-induced hypertension. In addition prevalent inflammatory kidney disease and hypertension, SLE patients suffer dysautonomia in the form decreased efferent vagal tone. Based on this, cholinergic anti-inflammatory pathway, an endogenous...
Sex is an important biological variable that impacts diverse physiological and pathological processes, including the progression of diabetic nephropathy. Diabetic nephropathy one most common complications diabetes mellitus leading cause end-stage renal disease. The endothelial nitric oxide synthase-deficient (eNOS-/-) db/db mouse appropriate valuable model to study mechanisms in development because similarities features kidney disease this those humans. aim present was determine whether...