A5011506185- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Biochemical Analysis and Sensing Techniques
- Hypothalamic control of reproductive hormones
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Animal Vocal Communication and Behavior
- Memory and Neural Mechanisms
- Infant Health and Development
- Neural dynamics and brain function
- Zebrafish Biomedical Research Applications
- Neurotransmitter Receptor Influence on Behavior
- Plant and animal studies
- Pancreatic function and diabetes
- Lipid Membrane Structure and Behavior
- Sleep and Wakefulness Research
- Photochromic and Fluorescence Chemistry
- Advanced Chemical Sensor Technologies
NYU Langone Health
2022-2024
New York University
2019-2023
New York Proton Center
2022
The University of Tokyo
2013-2022
Social behaviors are among the most important motivated behaviors. How dopamine (DA), a "reward" signal, releases during social has been topic of interest for decades. Here, we use genetically encoded DA sensor, GRAB
Neuropeptides are key signaling molecules in the endocrine and nervous systems that regulate many critical physiological processes. Understanding functions of neuropeptides vivo requires ability to monitor their dynamics with high specificity, sensitivity, spatiotemporal resolution. However, this has been hindered by lack direct, sensitive, noninvasive tools. We developed a series GRAB (G protein-coupled receptor activation‒based) sensors for detecting somatostatin (SST),...
Active defense against a conspecific aggressor is essential for survival. Previous studies revealed strong c-Fos expression in the ventrolateral part of ventromedial hypothalamus (VMHvl) defeated animals. Here, we examined functional relevance and vivo responses VMHvl during defense. We found that cells expressing estrogen receptor α (Esr1) are acutely excited active Optogenetic inhibition compromised an animal's ability to actively defend aggressor, whereas activating elicited defense-like...
Background Sexual imprinting is important for kin recognition and promoting outbreeding, has been a driving force evolution; however, little known about sexual by auditory cues in mammals. Male mice emit song-like ultrasonic vocalizations that possess strain-specific characteristics. Objectives In this study, we asked whether female imprint prefer specific characteristics male songs. Methods Findings We used the two-choice test to determine song preference of C57BL/6 BALB/c mice. By...
Abstract Mating drive is balanced by a need to safeguard resources for offspring, yet the neural basis negative regulation of mating remains poorly understood. In rodents, pheromones critically regulate sexual behavior. Here, we observe suppression adult female behavior in mice exocrine gland-secreting peptide 22 (ESP22), lacrimal protein from juvenile mice. ESP22 activates dedicated vomeronasal receptor, V2Rp4, and V2Rp4 knockout eliminates effects on Genetic tracing ESP22-responsive...
SUMMARY Neuropeptides are key signaling molecules in the endocrine and nervous systems that regulate many critical physiological processes, including energy balance, sleep circadian rhythms, stress, social behaviors. Understanding functions of neuropeptides vivo requires ability to monitor their dynamics with high specificity, sensitivity, spatiotemporal resolution; however, this has been hindered by lack direct, sensitive non-invasive tools. Here, we developed a series GRAB ( G...
The vomeronasal system plays an essential role in sensing various environmental chemical cues. Here we show that mice exposed to blood and, consequently, hemoglobin results the activation of sensory neurons expressing a specific G protein-coupled receptor, Vmn2r88, which is mediated by interaction site, Gly17, on hemoglobin. signal reaches medial amygdala (MeA) both male and female mice. However, it activates dorsal part ventromedial hypothalamus (VMHd) only lactating As result, mothers,...
Abstract As a peptide hormone and neuromodulator, oxytocin (OT) plays critical role in variety of physiological pathophysiological processes both the central nervous system periphery. However, that regulate spatial OT release brain remain enigmatic. Here, we developed genetically encoded GPCR activation-based (GRAB) sensor called GRAB OT1.0 . Using this sensor, directly visualized stimulation-induced from specific compartments neurons acute slices, discovered N-type calcium channels...
Male mice emit ultrasonic vocalizations (USVs) in response to the presence of female and their urine. USVs attract females, enhancing reproductive functions, are thus considered as courtship song. Previous studies have shown that exhibit disassortative social preferences for male USVs. However, it remains unclear what acoustic features use development these preferences. To address this, we examined C57BL/6 BALB/c using three-chamber preference test recorded dissociate peak frequencies from...
Summary Sexual and aggressive behaviors are two evolutionarily conserved social vital for an animal’s survival reproductive success. While increasing number of brain regions in the limbic system have been identified as functionally relevant these types behaviors, understanding how cues represented across generated via this network activity remains elusive. To gain a holistic view neural responses during we utilized multi-fiber photometry to simultaneously record Ca 2+ signals estrogen...
Sensory signals are critical to perform adaptive social behavior. During copulation, male mice emit ultrasonic vocalizations (USVs). Our previous studies have shown that female exhibit approach behavior toward sound sources of USVs and that, after being exposed a pheromone, exocrine gland-secreting peptide 1 (ESP1), exhibited preference particular type USVs. These findings suggest modulate courtship However, it remains unclear which brain regions what cell types neurons involved in neuronal...
Abstract To survive and thrive in a complex social group, it is essential to not only know who approach but more importantly avoid. After single defeat, mice learn stay away from the winning aggressor for weeks. Here, we identify oxytocin neurons retrochiasmatic supraoptic nucleus (SOR OXT ) receptor expressing cells anterior subdivision of ventromedial hypothalamus, ventrolateral part (aVMHvl OXTR as key circuit motif defeat-induced avoidance learning. aVMHvl drastically increase their...
Exocrine gland-secreting peptide 22 (ESP22) is a 10-kDa protein secreted in tears of juvenile mice. ESP22 inhibits sexual behaviors adults, leading to reduction reproduction rate. We herein identified the 24 amino acid sequence within that was essential for exhibiting rejection activity. This synthesizable can be useful controlling mouse overpopulation.