A5012186794- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- 14-3-3 protein interactions
- Cancer-related molecular mechanisms research
- Neurobiology and Insect Physiology Research
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Advanced Breast Cancer Therapies
- Asthma and respiratory diseases
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Receptor Mechanisms and Signaling
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Phosphodiesterase function and regulation
- Allergic Rhinitis and Sensitization
- Neurotransmitter Receptor Influence on Behavior
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
New York University
2020-2025
China Medical University
2020-2024
NYU Langone Health
2022-2024
Inner Mongolia Electric Power (China)
2024
Central South University
2024
Xiangya Hospital Central South University
2024
Ruijin Hospital
2020-2021
Shanghai Jiao Tong University
2020-2021
Shanghai Institute of Hematology
2020-2021
Tufts University
2018-2020
Social behaviors are among the most important motivated behaviors. How dopamine (DA), a "reward" signal, releases during social has been topic of interest for decades. Here, we use genetically encoded DA sensor, GRAB
Pyroptosis is closely relevant to sepsis. However, the molecular mechanisms of pyroptosis in pneumonia-induced sepsis are still not fully understood. Thus, this study aimed find specific pathways associated with and explore their relationship sepsis.First, significant signaling related were screened by bioinformatics analysis based on GSE48080. The peripheral blood samples from patients healthy subjects collected. Pneumonia-induced rat models also established. Then, inflammatory response,...
Development of selective kinase inhibitors remains a challenge due to considerable amino acid sequence similarity among family members particularly in the ATP binding site. Targeting activation loop might offer improved inhibitor selectivity since this region kinases is less conserved. However, strategy presents difficulties flexibility. Herein, we report design receptor-interacting protein 2 (RIPK2) based on pan-kinase regorafenib that aim engage basic residues Lys169 or Arg171. We...
The monoamine neuromodulator dopamine (DA) plays a critical role in the brain, and ability to directly measure dopaminergic activity is essential for understanding its physiological functions. We therefore developed first red fluorescent GPCR-activation–based DA (GRAB ) sensors optimized versions of green GRAB following our previous studies. In response extracellular DA, both have large increase fluorescence (ΔF/F 0 values 150% 340%, respectively), with subcellular resolution, subsecond...
Receptor-interacting protein kinase 2 (RIPK2) is a key mediator of nucleotide-binding oligomerization domain (NOD) cell signaling that has been implicated in various chronic inflammatory conditions. A new class RIPK2 kinase/NOD inhibitors based on 3,5-diphenyl-2-aminopyridine scaffold was developed. Several co-crystal structures RIPK2•inhibitor complexes were analyzed to provide insights into inhibitor selectivity versus the structurally related activin receptor-like (ALK2) demonstrating...
While brain regions function in coordination to mediate diverse behaviors, techniques allowing simultaneous monitoring of many deep remain limited. Here, we present a multi-fiber recording protocol that enables fluorescence signals from multiple freely behaving mice. We describe steps for assembling array and patch cord, implantation, recording. then detail procedures data extraction visualization. This comprehensive view the neural activity at network level. For complete details on use...
Omalizumab enables children who are intolerant to AIT initiate successfully. Combination therapy better improves asthma and rhinitis symptoms, FeNO, lung function compared single SCIT or omalizumab treatment. reduces the incidence of adverse reactions during initial phase enhances its safety.
Abstract Macrophages and oxidized low‐density lipoprotein (ox‐LDL) have been verified playing vital roles in the pathogenesis of atherosclerosis (AS). Previous studies demonstrated that microRNA‐29a (miR‐29a) was upregulated many atherogenic process cells, thus acting as an important participant AS. But detailed regulation mechanism miR‐29a AS has not fully understood. In our study, we a positive feedback loop ox‐LDL‐SRA‐miR‐29a. Furthermore, found YY1 STAT1 were ox‐LDL‐stimulating...
236 Background: Auranofin, an FDA anti-rheumatic agent shown to have anticancer properties for lung and ovarian cancer has never been studied pancreatic cancer. We hypothesize that Auranofin may prevent ductal adenocarcinoma (PDAC) progression by induction of apoptosis. Methods: performed in vitro vivo studies using human PDAC cell lines patient-derived xenografts (PDX) assess activity. Sensitivity the compound was determined based on IC 50 s. Western blot assay used interrogate mechanisms...
Summary Sexual and aggressive behaviors are two evolutionarily conserved social vital for an animal’s survival reproductive success. While increasing number of brain regions in the limbic system have been identified as functionally relevant these types behaviors, understanding how cues represented across generated via this network activity remains elusive. To gain a holistic view neural responses during we utilized multi-fiber photometry to simultaneously record Ca 2+ signals estrogen...
Chromosomal translocations and generating fusion genes are closely associated with disease initiation progression in acute myeloid leukemia (AML). In this study, we identified a novel t(X;17)(q28;q21) chromosomal rearrangement patient monocytic leukemia. Using RNA-sequencing, KANSL1-MTCP1 KANSL1-CMC4 gene. 5'-UTR sequences of the KANSL1 gene were found to become fused upstream coding sequence region MTCP1 CMC4 genes, respectively, resulting an aberrantly high expression these genes....
<h3>Background:</h3> Systemic sclerosis (SSc) is a class of heterogeneous autoimmune diseases, and fibrosis at the centre pathogenic triad SSc. Alternative splicing (AS) post-transcriptional regulatory process in which specific exons and/or introns precursor messenger RNA (pre-mRNA) are selectively included or excluded to generate multiple mature mRNA isoforms. AS encompasses several modes, including (SE), alternative 3' site (A3SS), 5' (A5SS), intron retention (IR) mutually exclusive (MXE)....
Abstract Objective. Distributed hypothalamic-midbrain neural circuits help orchestrate complex behavioral responses during social interactions. Given rapid advances in optical imaging, it is a fundamental question how population-averaged activity measured by multi-fiber photometry (MFP) for calcium fluorescence signals correlates with behaviors question. This paper aims to investigate the correspondence between MFP data and behaviors. Approach: We propose state-space analysis framework...
This cross-sectional study aimed to evaluate parents' knowledge, attitudes and practices (KAP) concerning the prevention treatment of dust mite allergy in children. survey was conducted from September December 2022 at Shengjing Hospital, Affiliated with China Medical University. A total 503 parents children allergies participated, 253 having undergoing desensitisation 250 whose did not. Selection criteria were carefully defined include directly responsible for caring allergies. Two distinct...