A5100332006- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Acute Ischemic Stroke Management
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Gestational Diabetes Research and Management
- Pulmonary Hypertension Research and Treatments
- COVID-19 and Mental Health
- Statistical Methods and Inference
- Dialysis and Renal Disease Management
- Diet and metabolism studies
- Mycobacterium research and diagnosis
- Head and Neck Surgical Oncology
- Renal cell carcinoma treatment
Eye & ENT Hospital of Fudan University
2020-2025
University of Dundee
2015-2025
Genomics (United Kingdom)
2020-2025
Peking University
2015-2025
Fudan University
2020-2025
China Medical University
2019-2025
Beijing Red Cross Blood Center
2025
First Hospital of China Medical University
2019-2025
National Health and Family Planning Commission
2023-2025
Zunyi Medical University
2021-2025
Recent research on long noncoding RNAs (lncRNAs) has expanded our understanding of gene transcription regulation and the generation cellular complexity. Depending their genomic origins, lncRNAs can be transcribed from intergenic or intragenic regions introns protein-coding genes. We have recently reported more than 6000 in Arabidopsis . Here, we systematically identified natural antisense transcripts (lncNATs), defined as opposite DNA strand coding found a total 37,238 sense–antisense...
Background. Seven persons in one family living eastern China developed fever and thrombocytopenia during May 2007, but the initial investigation failed to identify an infectious etiology. In December 2009, a novel bunyavirus (designated severe with syndrome [SFTSV]) was identified as cause of illness patients similar clinical manifestations China. We reexamined this cluster for SFTSV infection.
Object Hypothermia is by far the most potent neuroprotectant. Nevertheless, timely and safe delivery of hypothermia remains a clinical challenge. To maximize neuroprotection yet minimize systemic complications, ultra-early selective cerebral Emergency Medical Service (EMS) personnel in field would be advantageous. The authors (W.E. H.W.) have developed cooling helmet using National Aeronautics Space Administration spinoff technology. In this study its effectiveness lowering brain temperature...
The interaction between fat deposition and inflammation during obesity contributes to the development of non-alcoholic fatty liver disease (NAFLD). present study examined effects palmitoleate, a monounsaturated acid (16∶1n7), on metabolic inflammatory responses, investigated mechanisms by which palmitoleate increases hepatocyte synthase (FAS) expression. Male wild-type C57BL/6J mice were supplemented with subjected assays analyze hepatic steatosis response. Additionally, mouse primary...
Patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) have a high frequency of venous thromboembolic events and hypercoagulable state. As C5a-primed neutrophils play an important role in the development AAV, we investigated whether C5a-induced neutrophil tissue factor (TF)-expressing microparticles (MPs) extracellular traps (NETs) might promote hypercoagulability AAV.TF-expressing MPs were measured by flow cytometry. TF-expressing NETs assessed confocal microscopy....
Abstract Background and Aims The aims of this study were to investigate the proportion clinical irritable bowel syndrome (IBS) at a tertiary hospital in China, compare Rome III IV criteria with regard IBS diagnosis, describe agreement between criteria, identify differences IV‐positive ‐negative patients. Methods A cross‐sectional survey was performed among outpatients gastrointestinal (GI) department hospital. patients categorized as having using criteria. Results In total, 1,376 (91.7%)...
MicroRNAs (miRNAs) are dysregulated in a wide range of malignant diseases, confirming their crucial role tumor metastasis. MiRNA-30a-5p, member the miR-30 family, has been implicated many types cancers, including colorectal cancer, leading cause death worldwide.
Understanding the changing profiles of cardiovascular disease (CVD) and modifiable risk factors is essential for CVD prevention control. We aimed to report comprehensive trends in China from 1990 2019.Data on incidence, death, disability-adjusted life years (DALYs) total its 11 subtypes were obtained Global Burden Disease Study 2019. The burden attributable 12 was also retrieved. A secondary analysis conducted summarize leading causes factors.From 2019, number DALYs considerably increased by...
Background Early heart failure (HF) diagnosis is crucial to ensure that optimal guideline-directed medical therapy (GDMT) administered reduce morbidity and mortality. Limited access echocardiography could lead a later for patients, example, during an HF hospitalisation (hHF). This study aimed compare the incidence outcomes of inpatient versus outpatient HF. Methods Electronic health records were linked data between 2015 2021 from patients in Tayside, Scotland (population~450 000). Incident...
This study reports on the long-term stability of a recombinant 9-valent HPV vaccine, addressing gap in literature as previous research did not extend beyond 72 months. The vaccine targets types 6, 11, 16, 18, 31, 33, 45, 52, and 58 was produced using an E. coli expression system. We optimized soluble L1 protein by truncating N- C-termini, resulting virus-like particles (VLPs). Structural analysis confirmed VLPs' resemblance to natural ones, suitable for production. Stability testing...
Phospholipase C (PLC) ε is a recently identified enzyme regulated by wide range of molecules including Ras family small GTPases, Rho A, Gα 12/13 , and Gβγ with primary sites expression in the heart lung. In screen for human signal transduction genes altered during failure, we found that PLCε mRNA upregulated. Two murine models cardiac hypertrophy confirmed upregulation protein or RNA. To identify role function pathology, PLCε-deficient mouse strain was created. Echocardiography indicated −/−...
Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers. The mechanism(s) underlying deregulated expression the clinical consequences of changes not known. We used RT–PCR, qPCR, methylation-specific PCR pyrosequencing to analyse regulation NT5E melanoma cell lines primary metastatic melanomas. is subject epigenetic mRNA downregulated by...
Enforced expression of miR-34a eliminates cancer stem cells in some malignant tumors. Sirtuin-1 (SIRT1) is a direct target miR-34a. Here we found low levels and high SIRT1 CD44+/CD24- breast (BCSCs). MiR-34a overexpression knockdown decreased proportion BSCSs mammosphere formation. Expression CSC markers, ALDH1, BMI1 Nanog was decreased. In nude mice xenografts, stable silencing reduced tumor burden. Taken together, our results demonstrated that inhibits proliferative potential BCSCs vitro...
Noncoding RNAs (ncRNAs), primarily microRNAs and long ncRNAs, play important roles in lung cancer. However, the role of ncRNA (lncRNA)-X-inactive specific transcript (XIST) non-small-cell cancer (NSCLC) is unclear. The purpose this study was to explore biologic function potential mechanism XIST NSCLC progression.XIST, miR-137, Notch-1 expression were detected by quantitative real-time PCR (qRT-PCR). Levels proliferation- epithelial-mesenchymal transition (EMT)-related proteins assessed...
The associations of maternal cigarette smoking with congenital anomalies in offspring have been inconsistent. This study aimed to clarify the timing and intensity 12 subtypes birth based on a nationwide large cohort USA.We used certificate data from US National Vital Statistics System during 2016-2019. Women reported average daily number cigarettes they consumed 3 months before pregnancy each subsequent trimester pregnancy. Twelve were identified medical records. Poisson regression analysis...
Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze oxidation lysine ε-amino groups on the extracellular matrix proteins to form aldehyde containing amino acid allysine (Lys