A5078136816- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Liver Diseases and Immunity
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Pediatric Hepatobiliary Diseases and Treatments
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Gut microbiota and health
- Regulation of Appetite and Obesity
- interferon and immune responses
- Liver Disease and Transplantation
- Diabetes and associated disorders
- Birth, Development, and Health
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Immune cells in cancer
- Pregnancy and preeclampsia studies
Texas A&M University
2016-2025
Mitchell Institute
2009-2025
College Station Medical Center
2018-2024
Southern Medical University
2024
Indiana University – Purdue University Indianapolis
2022
Indiana University School of Medicine
2022
University of Rome Tor Vergata
2022
Sapienza University of Rome
2022
Richard L. Roudebush VA Medical Center
2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
Background— Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1- M2-mediated signaling pathways corresponding cytokine production profiles are not completely understood. The discovery microRNAs provides new opportunity understand this complicated but network for...
Transmembrane protein 173 (TMEM173 or STING) signaling by macrophage activates the type I interferon-mediated innate immune response. The response contributes to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). We investigated whether STING regulates diet-induced in steatosis, inflammation, fibrosis mice.Mice with disruption of Tmem173 (STINGgt) on a C57BL/6J background, mice without this gene (controls), only myeloid cells were fed standard chow diet, high-fat diet (HFD; 60%...
Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes (T2D) compared with age-matched men, but this advantage disappears after menopause disrupted glucose homeostasis, in part owing to a reduction circulating 17β-estradiol (E2). Fasting hyperglycemia is hallmark T2D derived largely from dysregulation hepatic production (HGP), which Foxo1 plays central role the regulation gluconeogenesis. Here, we investigated action E2 on homeostasis male...
Vascular cells, particularly endothelial adopt aerobic glycolysis to generate energy support cellular functions. The effect of on angiogenesis remains unclear. 6-Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, isoform 3 (PFKFB3) is a critical enzyme for glycolysis. By blocking or deleting PFKFB3 in we investigated the influence both vitro and vivo.Under hypoxic conditions after treatment with angiogenic factors, was upregulated vivo. knockdown overexpression suppressed accelerated...
Significance Lung endothelial cells express high levels of glucose metabolic enzymes, such as PFKFB3, and consequently produce large amounts metabolites. These metabolites are able to stabilize the cell signaling molecule HIF2A, similar that which occurs under hypoxic conditions. This stabilization HIF2A by in lung stimulates production growth inflammatory factors, thereby enhancing proliferation inflammation pulmonary vessels exacerbating hypertension (PH). In this study, blockade PFKFB3...
This study aimed to assess the effects of three major SCFAs (acetate, propionate, and butyrate) on NASH phenotype in mice. C57BL/6 mice were fed a methionine- choline-deficient (MCD) diet treated with sodium acetate, or butyrate during 6-week feeding period. SCFA treatment significantly reduced serum levels alanine aminotransferase aspartate transaminase, numbers lipid droplets, triglycerides cholesterols livers compared control treatment. also MCD-induced hepatic aggregation macrophages...
Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance. To better understand the pathophysiology of obesity-associated NAFLD, present study examined involvement adipose tissues in metformin actions on reducing hepatic steatosis inflammation during obesity. C57BL/6J mice were fed a high-fat diet (HFD) for 12 weeks to induce NAFLD treated (150 mg/kg/d) orally last four HFD feeding. Compared HFD-fed control mice, metformin-treated showed improvement...
Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion and metabolic functions various cells. Depending on cell types, rates glycolysis are determined at steps that subjected to the control key regulatory enzyme(s), which include glucokinase, 6-phosphofructo-1-kinase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. These enzymes regulated by both nutritional hormonal signals levels transcription, translation, post-translational modifications. In...
The interaction between fat deposition and inflammation during obesity contributes to the development of non-alcoholic fatty liver disease (NAFLD). present study examined effects palmitoleate, a monounsaturated acid (16∶1n7), on metabolic inflammatory responses, investigated mechanisms by which palmitoleate increases hepatocyte synthase (FAS) expression. Male wild-type C57BL/6J mice were supplemented with subjected assays analyze hepatic steatosis response. Additionally, mouse primary...
Abstract Increased aerobic glycolysis in endothelial cells of atheroprone areas blood vessels has been hypothesized to drive increased inflammation and lesion burden but direct links remain be established. Here we show that exposed disturbed flow vivo vitro exhibit levels protein kinase AMP-activated (PRKA)/AMP-activated kinases (AMPKs). Selective deletion Prkaa1 , coding for catalytic subunit alpha1, reduces glycolysis, compromises cell proliferation, accelerates the formation...
Abstract Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR improves aspects of NAFLD. Here we revealed an AMP-activated protein kinase (AMPK)-independent mechanism suppress inflammation and improve hepatic steatosis. In C57BL/6J mice fed a high-fat diet (HFD), treatment with decreased in both the adipose tissue as indicated by reduction phosphorylation state JNK1...
Adenosine/adenosine receptor-mediated signaling has been implicated in the development of various ischemic diseases, including retinopathies. Here, we show that adenosine A2a receptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cell glycolysis, which is crucial for pathological angiogenesis proliferative Adora2a expression markedly increased retina mice with oxygen-induced retinopathy (OIR). Endothelial cell-specific, but not macrophage-specific...
Background and Aims Indole is a microbiota metabolite that exerts anti‐inflammatory responses. However, the relevance of indole to human non‐alcoholic fatty liver disease (NAFLD) not clear. It also remains largely unknown whether how acts protect against NAFLD. The present study sought examine association between circulating levels fat content in subjects explore mechanisms underlying actions mice with diet‐induced Approach Results In cohort 137 subjects, were reversely correlated body mass...
The molecular mechanisms underlying vascular inflammation and associated inflammatory diseases are not well defined. Here we show that endothelial intracellular adenosine its key regulator kinase (ADK) play important roles in inflammation. Pro-inflammatory stimuli lead to by increasing ADK expression, reducing the level of cells, activating transmethylation pathway through association with S-adenosylhomocysteine (SAH) hydrolase (SAHH). Increasing genetic knockdown or exogenous reduces...
Clinical and experimental evidence suggests that obesity-associated inflammation increases disease activity during colitis, attributed in part to the effects of Th17 cells. Using a model concurrent obesity we monitored changes critical immune cell subsets inflammatory biomarker expression three key tissues: visceral adipose tissue, colon (local site) spleen (systemic site), hypothesized n-3 PUFA would reduce percentage suppress gene expression, thereby improving phenotype. Obesity was...
Abstract The nucleoside adenosine is a potent regulator of vascular homeostasis, but it remains unclear how expression or function the adenosine‐metabolizing enzyme kinase (ADK) and intracellular levels influence angiogenesis. We show here that hypoxia lowered ADK increased in human endothelial cells. Knockdown (KD) elevated adenosine, promoted proliferation, migration, angiogenic sprouting Additionally, mice deficient displayed angiogenesis as evidenced by rapid development retinal...
Purposes We have previously reported that Ginsenoside Rb1 may effectively prevent HUVECs from senescence, however, the detailed mechanism has not demonstrated up to now. Recent studies shown sirtuin-1 (Sirt1) plays an important role in development of endothelial senescence. The purpose this study was explore whether Sirt1 is involved action regarding protection against H2O2-induced HUVEC Senescence. Methods and Results Senescence induced by hydrogen peroxide (H2O2) human umbilical vein cells...
Adenosine 2A receptor (A2AR) exerts protective roles in endotoxin‐ and/or ischemia‐induced tissue damage. However, the role for A2AR nonalcoholic fatty liver disease (NAFLD) remains largely unknown. We sought to examine effects of global myeloid cell‐specific disruption on aspects obesity‐associated NAFLD and elucidate underlying mechanisms. Global cell–specific A2AR‐disrupted mice control were fed a high‐fat diet (HFD) induce NAFLD. In addition, bone marrow–derived macrophages primary mouse...