A5002919496- Gene Regulatory Network Analysis
- Protein Structure and Dynamics
- Theoretical and Computational Physics
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Enzyme Structure and Function
- Fungal and yeast genetics research
- RNA and protein synthesis mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
- Spaceflight effects on biology
- Neurobiology and Insect Physiology Research
- Physics of Superconductivity and Magnetism
- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- Machine Learning in Bioinformatics
- Plant Molecular Biology Research
- Gene expression and cancer classification
- Material Dynamics and Properties
Peking University
2016-2025
Center for Life Sciences
2016-2025
Chengdu University
2023-2025
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2025
China Railway Signal & Communication (China)
2025
King Center
2014-2025
King University
2019-2025
Hunan Normal University
2021-2025
Sensors (United States)
2025
El Paso Community College
2025
We show that dynamical systems with spatial degrees of freedom naturally evolve into a self-organized critical point. Flicker noise, or 1/f can be identified the dynamics state. This picture also yields insight origin fractal objects.
We show that certain extended dissipative dynamical systems naturally evolve into a critical state, with no characteristic time or length scales. The temporal ``fingerprint'' of the self-organized state is presence flicker noise 1/f noise; its spatial signature emergence scale-invariant (fractal) structure.
The Gutenberg‐Richter power law distribution for energy released at earthquakes can be understood as a consequence of the earth crust being in self‐organized critical state. A simple cellular automaton stick‐slip type model yields D ( E ) ≈ −τ with τ≈1.0 and τ≈1.35 two three dimensions, respectively. size is unpredictable since evolution an earthquake depends crucially on minor details crust.
The interactions between proteins, DNA, and RNA in living cells constitute molecular networks that govern various cellular functions. To investigate the global dynamical properties stabilities of such networks, we studied cell-cycle regulatory network budding yeast. With use a simple model, it was demonstrated is extremely stable robust for its function. biological stationary state, G 1 attractor dynamics. pathway, sequence protein states, globally attracting trajectory These are largely...
A one-dimensional Schr\"odinger equation in a discontinuous quasiperiodic potential is reduced to recursion relation for transfer matrices and then one traces of these matrices. When the periodic, bandwidth goes zero as an algebraic function period with critical index which depends upon strength. This also evaluated solution escape-rate problem relations.
This review is an expository treatment of the displacement one fluid by another in a two-dimensional geometry (a Hele-Shaw cell). The Saffman-Taylor equations modeling this system are discussed. They simulated random-walk techniques and studied methods from complex analysis. stability generated patterns (fingers) WKB approximation analytic techniques. primary conclusions reached that (a) fingers linearly stable even at highest velocities, (b) they nonlinearly unstable against noise or...
The electronic properties of a tight-binding model which possesses two types hopping matrix element (or on-site energy) arranged in Fibonacci sequence are studied. wave functions either self-similar (fractal) or chaotic and show ``critical'' ``exotic'') behavior. Scaling analysis for the at center band also edge is performed. energy spectrum Cantor set with zero Lebesque measure. density states singularly concentrated an index ${\ensuremath{\alpha}}_{E}$ takes value range...
A simple negative feedback loop of interacting genes or proteins has the potential to generate sustained oscillations. However, many biological oscillators also have a positive loop, raising question what advantages extra imparts. Through computational studies, we show that it is generally difficult adjust oscillator's frequency without compromising its amplitude, whereas with positive-plus-negative feedback, one can achieve widely tunable and near-constant amplitude. This tunability makes...
Protein structures in nature often exhibit a high degree of regularity (secondary structures, tertiary symmetries, etc.) absent random compact conformations. We demonstrate simple lattice model protein folding that structural regularities are related to designability and evolutionary stability. measure the each structure by number sequences which can design structure, i.e., possess as their nondegenerate ground state. find drastically different terms designability; highly designable emerge...
Critical indices $\ensuremath{\beta}$, $\ensuremath{\gamma}$ $\ensuremath{\delta}$, $\ensuremath{\nu}$, etc. are defined and calculated for self-organized critical phenomena. Scaling relations derived checked numerically. The order-parameter exponent $\ensuremath{\beta}$ describes the spontaneous current relaxation to point. power spectrum has "$\frac{1}{f}$" behavior with $\ensuremath{\varphi}=\frac{\ensuremath{\gamma}}{\ensuremath{\nu}z}$, where $z$ is dynamical exponent.
Abstract A classic problem in microbiology is that bacteria display two types of growth behavior when cultured on a mixture carbon sources: the sources are sequentially consumed one after another (diauxie) or they simultaneously (co-utilization). The search for molecular mechanism diauxie led to discovery lac operon. However, questions remain as why microbes would bother have different strategies taking up nutrients. Here we show versus co-utilization can be understood from topological...
Neuropeptides are key signaling molecules in the endocrine and nervous systems that regulate many critical physiological processes. Understanding functions of neuropeptides vivo requires ability to monitor their dynamics with high specificity, sensitivity, spatiotemporal resolution. However, this has been hindered by lack direct, sensitive, noninvasive tools. We developed a series GRAB (G protein-coupled receptor activation‒based) sensors for detecting somatostatin (SST),...
Abstract The accuracy of volume flow rate measurements obtained with phase‐contrast methods was assessed by means computer simulation and in vitro experiments. Factors studied include (a) the partial‐volume effect due to voxel dimensions relative vessel orientation (b) intravoxel phase dispersion. It is shown that limited resolution (partial‐volume effect) major obstacle accurate measurement for both laminar plug flow. results show at least 16 voxels must cover cross section lumen obtain a...
In a statistical approach to protein structure analysis, Miyazawa and Jernigan derived $20\ifmmode\times\else\texttimes\fi{}20$ matrix of inter-residue contact energies between different types amino acids. Using the method eigenvalue decomposition, we find that Miyazawa-Jernigan can be accurately reconstructed from its first two principal component vectors as ${M}_{\mathrm{ij}}{\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}C}_{0}{+C}_{1}({q}_{i}{+q}_{j}){+C}_{2}{q}_{i}{q}_{j}$, with...
We present a detailed numerical study of certain fundamental aspects one-dimensional homogeneous, deterministic Burridge-Knopoff model. The model is described by massive wave equation, in which the key nonlinearity associated with stick-slip velocity-weakening friction force at interface between tectonic plates. In this paper, we results for statistical distribution slipping events limit very long fault and infinitesimally slow driving rates. Typically, find that magnitude smaller consistent...
A random-walk model is proposed to simulate Darcy-law two-dimensional flows in hydrodynamics the limit of zero-surface tension. The simulation compared with analytic and numerical results latter steady-state dynamic cases, respectively. instabilities a flat interface are studied linear region. It clear that mean-field diffusion-limited aggregation Saffman-Taylor problem.
Drugs against multiple targets may overcome the many limitations of single and achieve a more effective safer control disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification drug their best intervention requires knowledge underlying disease network calls for innovative computational methods that exploit structure dynamics. Here, we develop robust algorithm finding target optimal (MTOI) solutions network. MTOI identifies...
A tight-binding model in one dimension with an incommensurate potential ${V}_{n}=\ensuremath{\lambda}cos(2\ensuremath{\pi}\ensuremath{\sigma}n)$ is investigated. It found that at the critical point of localization transition $\ensuremath{\lambda}=2$, there a finite range scaling indices ${\ensuremath{\alpha}}_{min}\ensuremath{\le}\ensuremath{\alpha}\ensuremath{\le}{\ensuremath{\alpha}}_{max}$ each which associated fractal $\mathcal{f}(\ensuremath{\alpha})$. In extended region...