A5066071426- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Pancreatic function and diabetes
- Bioinformatics and Genomic Networks
- Viral Infections and Vectors
- Plant-based Medicinal Research
- HIV Research and Treatment
- Vitamin C and Antioxidants Research
- Diabetes Management and Research
- Diabetes and associated disorders
- Medicinal Plants and Bioactive Compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects and Toxicity Studies
- Sugarcane Cultivation and Processing
- Pluripotent Stem Cells Research
- Plant nutrient uptake and metabolism
- Immune responses and vaccinations
- Influenza Virus Research Studies
- Agricultural Science and Fertilization
- Mycorrhizal Fungi and Plant Interactions
- Malaria Research and Control
Shenzhen Pingle Orthopedic Hospital
2020-2023
East Tennessee State University
2023
Guangzhou University of Chinese Medicine
2020-2023
ShenZhen People’s Hospital
2020
Guangxi Normal University
2019
Northwestern Polytechnical University
2010
Hong Kong Baptist University
2004
Roots are important plant organs. Lateral root (LR) initiation (LRI) and development play a central role in environmental adaptation. The mechanism of LR has been well investigated Arabidopsis. When we evaluated the distribution auxin abscisic acid (ABA) maize, found that differed from ABA within primary roots (PRs) LRs was independent each other. Auxin localization observed below quiescent center tips, while localized at top center. Furthermore, NaCl inhibited LRI by increasing...
The effects of arbuscular mycorrhizal fungi Glomus mosseae (+AMF) on the growth, nutrient uptake and leaf photosynthetic characteristics alfalfa (Medicago sativa) under salt stress were studied. In alfalfa, 100 mM had no obvious effect plant content capacity, however, 200 significantly inhibited biomass accumulation NPK uptake. addition, led to decreased carbon assimilation capacity lower PSII PSI activity levels. Cultivation alfafa with +AMF promoted nutrients, increased its underground P...
Abstract Background Chinese medicine Xuebijing (XBJ) has proven to be effective in the treatment of mild coronavirus disease 2019 (COVID-19) cases. But bioactive compounds and potential mechanisms XBJ for COVID-19 prevention are unclear. This study aimed examine effector on based network pharmacology. Methods We searched international papers obtain active ingredients XBJ. Then, we compiled targets from GeneCards gene database via literature searches. Next, used SwissTargetPrediction predict...
We have previously demonstrated mitochondrial dysfunction in aging CD4 T cells from antiretroviral therapy (ART)-controlled people living with HIV (PLWH). However, the underlying mechanisms by which develop PLWH remain unclear. In this study, we sought to elucidate mechanism(s) of cell compromise ART-controlled PLWH. first assessed levels reactive oxygen species (ROS), and observed significantly increased cellular ROS compared healthy subjects (HS). Furthermore, a significant reduction...
Influenza A virus (IAV) poses a severe threat to human health and is major public problem worldwide. As global anti-influenza drug resistance has increased significantly, there an urgent need develop new antiviral drugs, especially drugs from natural products. Isoimperatorin, active furanocoumarin, exhibits broad range of pharmacologic activities including anticoagulant, analgesic, anti-inflammatory, antibacterial, anti-tumor, other pharmacological effects, so it attracted more attention. In...
Background: Coronavirus disease 2019 (COVID-19) is now a worldwide public health crisis. The causative pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Novel therapeutic agents are desperately needed. Because of the frequent mutations in virus and its ability to cause cytokine storms, targeting viral proteins has some drawbacks. Targeting cellular factors or pivotal inflammatory pathways triggered by SARS-CoV-2 may produce broader range therapies. Glycyrrhizic acid (GA)...
Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created global health emergency. However, the underlying pathogenic mechanisms remain elusive. We investigated host response features vivo replication mouse model infection, by performing series transcriptomic and bioinformatic analyses mock-infected brain tissue. Tissue damage, inflammatory cells infiltration high viral were observed tissue infected mice. RNA-Seq indicated activation ferroptosis pathways. Enrichment...
Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects expected become a potential COVID-19 PF comorbidities. Therefore, this study explored the targets molecular mechanisms of kaempferol against co-occurrence by bioinformatics network pharmacology. Methods: Various open-source databases Venn...
Background The outbreak of Coronavirus disease 2019 (COVID-19) has become an international public health crisis, and the number cases with dengue co-infection raised concerns. Unfortunately, treatment options are currently limited or even unavailable. Thus, aim our study was to explore underlying mechanisms identify potential therapeutic targets for co-infection. Methods To further understand co-infection, we used a series bioinformatics analyses build host factor interaction networks...
Background: Ganghuo Kanggan decoction (GHKGD) is a clinical experience prescription used for the treatment of viral pneumonia in Lingnan area China, and its effect remarkable. However, mechanism GHKGD influenza still unclear. Objective: To predict active components signaling pathway to explore therapeutic verified it vivo using network pharmacology. Methods: The potential targets were hypothesized through series pharmacological strategies, including compound screening, target prediction...
Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of and COPD comorbidities is accumulating. However, data revealing the molecular mechanism comorbid diseases limited. Methods: We got COVID-19/COPD -related genes from different databases by restricted screening conditions (top500), respectively, then supplemented with COVID-19/COPD-associated (FDR<0.05, |LogFC|≥1) clinical sample sets. By taking intersection, 42...
Abstract Zika virus (ZIKV) infection poses a significant threat to global public health and is associated with microcephaly. There are no approved ZIKV‐specific vaccines or drugs for the clinical treatment of infection. Currently, there In this study, we investigated antiviral potential aloperine, quinolizidine alkaloid, against ZIKV in vivo vitro. Our results demonstrate that aloperine effectively inhibits vitro, low nanomolar half maximal effective concentration (EC 50 ). Specifically,...
Abstract Objective To study the mechanisms of Hanshi Zufei syndrome formula (HSZF) for coronavirus disease 2019 (COVID-19) using network pharmacology. Methods We screened potential active constituents (oral bioavailability [OB] ≥ 30%, drug-likeness [DL] 0.18) HSZF Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, predicted targets Swiss TargetPrediction constructed a pharmacologically active-compound–potential-target and protein–protein interaction (PPI) Cytoscape software,...
Abstract Objective: To examine the potential effector mechanisms of Xuebijing (XBJ) on coronavirus disease 2019 (COVID-19) based network pharmacology. Methods: We searched Chinese and international papers to obtain active ingredients XBJ. Then, we compiled COVID-19 targets from GeneCards gene database via literature searches. Next, used SwissTargetPrediction predict XBJ’s map them abovementioned in order therapeutic Cytoscape software version 3.7.0 was construct a “XBJ...