A5101848485- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Connective tissue disorders research
- Viral Infections and Vectors
- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Crystallization and Solubility Studies
- Extracellular vesicles in disease
- Antimicrobial Peptides and Activities
- Shoulder Injury and Treatment
- Genomics, phytochemicals, and oxidative stress
- Tendon Structure and Treatment
- Malaria Research and Control
- Respiratory viral infections research
- Corneal Surgery and Treatments
- Ginseng Biological Effects and Applications
- Immune cells in cancer
- Gas Sensing Nanomaterials and Sensors
- S100 Proteins and Annexins
National Clinical Research Center for Digestive Diseases
2021-2025
Capital Medical University
2021-2025
Guangzhou University of Chinese Medicine
2021-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022-2024
Xuan Wu Hospital of the Capital Medical University
2023
Hunan University of Traditional Chinese Medicine
2023
Guilin University of Technology
2022
Tianjin University
2021
Johns Hopkins University
2021
Taiyuan University of Technology
2014
Achondroplasia is the most common genetic skeletal disorder causing disproportionate short stature/dwarfism. Common additional features include spinal stenosis, midface retrusion, macrocephaly and a generalized spondylometaphyseal dysplasia which manifest as cord compression, sleep disordered breathing, delayed motor skill acquisition genu varus with musculoskeletal pain. To better understand interactions health outcomes of these potential complications, we embarked on multi-center, natural...
Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created global health emergency. However, the underlying pathogenic mechanisms remain elusive. We investigated host response features vivo replication mouse model infection, by performing series transcriptomic and bioinformatic analyses mock-infected brain tissue. Tissue damage, inflammatory cells infiltration high viral were observed tissue infected mice. RNA-Seq indicated activation ferroptosis pathways. Enrichment...
Abstract Airway epithelial transcriptome analysis of asthma patients with different severity was used to disentangle the immune infiltration mechanisms affecting exacerbation, which may be advantageous treatment. Here we introduce various bioinformatics methods and develop two models: an OVA/CFA-induced neutrophil mouse model LPS-induced human bronchial cell damage model. Our objective is investigate molecular mechanisms, potential targets, therapeutic strategies associated severity....
(1) Background: Ginsenoside Rb1-PLGA nanoparticles (GRb1@PLGA@NPs) represent a novel nanotherapeutic system, yet their therapeutic efficacy and underlying mechanisms for treating heart failure (HF) remain unexplored. This study aims to investigate the potential effects of GRb1@PLGA@NPs in HF treatment; (2) Methods: The left anterior descending coronary artery ligation was employed establish model Sprague-Dawley rats, along with an vitro oxidative stress using H9c2 myocardial cells. Following...
Monocentric, retrospective, cross-sectional study. To investigate the age-related normative values of sagittal parameters and establish their relationships in asymptomatic community-dwelling adults aged over 50. Degenerative changes spine with aging alter balance, causing pathologies. However, there was a lack comprehensive study on alignment relationship during degenerative evolution. Among total 1,370 volunteers, 701 volunteers were recruited. Participants underwent lateral X-ray, assessed...
Cervical sagittal alignment changes (CSACs) influence outcomes and health-related quality-of-life. Anterior cervical discectomy fusion (ACDF), laminectomy with (LCF), laminoplasty (LP) are common treatments for multisegmental spondylotic myelopathy; however, these approaches need to be compared.Our study included 167 patients who underwent ACDF, LCF, or LP. Patients were divided into four groups according C2-C7 Cobb angle (CL): kyphosis (CL < 0°), straight (0° ≤ CL 10°), lordosis (10° 20°),...
Background The outbreak of Coronavirus disease 2019 (COVID-19) has become an international public health crisis, and the number cases with dengue co-infection raised concerns. Unfortunately, treatment options are currently limited or even unavailable. Thus, aim our study was to explore underlying mechanisms identify potential therapeutic targets for co-infection. Methods To further understand co-infection, we used a series bioinformatics analyses build host factor interaction networks...
Abstract Purpose Cervical laminoplasty (CLP) is a developed surgical procedure for the treatment of cervical spondylotic myelopathy (CSM), but only few those studies focus on preoperative dynamic sagittal alignment and study different degrees loss lordosis (LCL) lacking. This aimed to analyze patients who underwent CLP investigate effect extension flexion function LCL. Methods In this retrospective case–control study, we analyzed 79 CSM between January 2019 December 2020. We measured...
A new type of 2D metal–organic framework (MOF), namely Cu-MOF, was constructed from Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O and the novel ligand 1,4-bis(4-naphthoic acid)benzene.
Study Design. Retrospective study. Objective. To investigate factors associated with cervical sagittal imbalance (CSI) after laminoplasty (LMP). Summary of Background Data. Preoperative dynamic alignment is an important predictor for changes in and clinical outcomes LMP. However, the impact preoperative on postoperative vertical axis (cSVA) LMP remains unclear. We hypothesized that flexion extension function are cSVA found potential risk post-LMP CSI. Patients Methods. undergoing at a single...
This study aimed to determine the anticolitic effect of Desmodium styracifolium (DS) extract in ulcerative colitis (UC) mice and its possible antioxidative mechanisms. Phenolic antioxidants free radical scavenging activities herb were determined. LCMS was used identify phenolic compounds herbal extract. Ulcerative C57BL/6 SPF induced with dextran sodium sulfate (DSS). The treated two doses DS during 7-day experiment. Colon length, spleen weight, histopathological changes colonic tissues,...
The infection of Nocardia gipuzkoensis is a relatively uncommon form pulmonary nocardiosis seen in clinical patients. In general, tends to occur patients with immune deficiency. Here, we report 23-year-old female who was admitted the hospital due cough and sputum production over 10 years, diagnosed bronchiectasis. N. identified by metagenomic next-generation sequencing whole genome sequencing. Imipenem/cilastatin compound sulfamethoxazole tablets were used control inflammation subsided gradually.
A novel metal-organic framework (MOF) with two-dimensional (2D) crystal structure was developed using Cu(NO3)2·3H2O and 2,2',5,5'-tetramethoxy-[1,1'-biphenyl]-4,4'-dicarboxylic acid. Further, its characterized infrared spectroscopy, thermogravimetry, X-ray diffraction, crystallography. The activated Cu-MOF used to catalyze the dehydrogenative oxidation of alcohol N-arylation azole compounds. Furthermore, it could be easily recovered reused.
Background: The COVID-19 pandemic poses an imminent threat to humanity, especially for those who have comorbidities. Evidence of and COPD comorbidities is accumulating. However, data revealing the molecular mechanism comorbid diseases limited. Methods: We got COVID-19/COPD -related genes from different databases by restricted screening conditions (top500), respectively, then supplemented with COVID-19/COPD-associated (FDR<0.05, |LogFC|≥1) clinical sample sets. By taking intersection, 42...
Cervical sagittal parameters have been widely used to predict clinical outcomes in patients with cervical spondylotic myelopathy (CSM). This study aims coin a novel parameter defined as the ratio of vertical axis T1 slope (CSVA/T1S) and investigate correlation between CSVA/T1S postoperative HRQOL after laminoplasty.A total 102 CSM treated laminoplasty from our database were retrospectively reviewed. All followed up for >12 months. Radiological measured using lateral radiographs, including...
Abstract Purpose This study aimed to evaluate the cervical sagittal profile after spontaneous compensation of global imbalance and analyze associations between changes in alignment spinopelvic parameters. Methods In this retrospective radiographic study, we analyzed 90 patients with degenerative lumbar stenosis (DLS) who underwent short fusion (imbalance group). We used 60 DLS balance as control group (balance Patients were also divided into two groups according preoperative PI: low PI (≤...
Most COVID-19 survivors are troubled with chronic persistent symptoms, which have currently no definitive treatments. Bufei Huoxue (BFHX) capsule exerts clinical benefit, while the material basis and molecular mechanism remain unclear.
Abstract Objective. To identify factors associated with T1 slope (T1S). Methods. A total of 215 patients over 18 years old who underwent whole-spine X-rays to evaluate lower back pain were enrolled in this study. T1S, pelvic tilt (PT), sacral (SS), incidence (PI), thoracic kyphosis (TK), lumbar lordosis (LL), cervical (CL), thoracolumbar (TLK), and sagittal vertical axis (SVA) measured. Patients divided into balance, compensatory compensation, decompensation groups. Results. TK (p <...
Abstract Purpose Cervical laminoplasty (CLP) is a developed surgical procedure for the treatment of cervical spondylotic myelopathy (CSM), but only few those studies focus on preoperative dynamic sagittal alignment and study different degrees loss lordosis (LCL) lacking. This aimed to analyze patients who underwent CLP investigate effect extension flexion function LCL. Methods was retrospective between January 2019 December 2020. The (CL), T1 slope (T1S), vertical axis (cSVA), CL in (Flex...