A5101750585- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Phytochemistry and Biological Activities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traditional Chinese Medicine Analysis
- Mosquito-borne diseases and control
- Phytochemicals and Antioxidant Activities
- Heavy metals in environment
- Neurological Disease Mechanisms and Treatments
- Viral Infections and Vectors
- Advanced MRI Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Microbial Community Ecology and Physiology
- Cancer, Lipids, and Metabolism
- Heat shock proteins research
- Metabolomics and Mass Spectrometry Studies
- Cardiac Ischemia and Reperfusion
- Colorectal Cancer Surgical Treatments
- COVID-19 Clinical Research Studies
- Essential Oils and Antimicrobial Activity
- Bioactive Natural Diterpenoids Research
- Vibration Control and Rheological Fluids
- Heavy Metals in Plants
Guangzhou University of Chinese Medicine
2016-2025
Shandong University of Traditional Chinese Medicine
2025
First Hospital of Jiaxing
2025
Jiaxing University
2025
Yunnan Agricultural University
2024-2025
Hainan University
2025
Ministry of Education of the People's Republic of China
2019-2024
Jinan University
2015-2024
Huazhong University of Science and Technology
2023
Tongji Hospital
2023
Regulation of the activity pyruvate dehydrogenase complex in skeletal muscle plays an important role fuel selection and glucose homeostasis. Activation promotes disposal glucose, whereas inactivation conserves substrates for hepatic production. Starvation diabetes induce a stable increase kinase mitochondria that phosphorylation complex. The present study shows these metabolic conditions large expression PDK4, one four isoenzymes expressed mammalian tissues, gastrocnemius muscle. Refeeding...
The influence of natural regulatory T cells (nTregs) on the patients with colon cancer is unclear. Demethylated status Treg-specific demethylated region (TSDR) FOXP3 gene was reported to be a potential biomarker for identification nTregs. demethylation rate TSDR (TSDR-DMR) calculated by using methylation-specific quantitative polymerase chain reaction (MS-qPCR) assay. expression TSDR-DMR and mRNA investigated in various colorectal cell lines. A total 130 carcinoma samples were utilized study...
Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created global health emergency. However, the underlying pathogenic mechanisms remain elusive. We investigated host response features vivo replication mouse model infection, by performing series transcriptomic and bioinformatic analyses mock-infected brain tissue. Tissue damage, inflammatory cells infiltration high viral were observed tissue infected mice. RNA-Seq indicated activation ferroptosis pathways. Enrichment...
Ferroptosis-related genes have been reported to play important roles in many diseases, but their molecular mechanisms osteoporosis not elucidated. Based on two independent GEO datasets (GSE35956 and GSE35958), GSE35959 as the validation dataset, we comprehensively elucidated pathological mechanism of ferroptosis-related by GO analyses, KEGG analyses a PPI network. Then, We used Western Blot (WB) Quantitative real-time polymerase chain reaction (qPCR) verify expression level KMT2D, hub gene,...
<title>Abstract</title> <bold>Background:</bold> Previous studies have indicated that the fat fraction of bone can reflect quality. The purpose this study is to discuss relationship between proximal humerus and its density in patients with rotator cuff tears. <bold>Methods:</bold> All tears from same institution December 1 31, 2023, were included. Bone was measured using dual-energy X-ray absorptiometry (DXA), data MRI. regions interest (a, b, c) analyzed for correlation their own lumbar...
Breast cancer has now become the most prevalent worldwide. Existing therapeutic agents are generally accompanied by significant side effects. Here, we highlight Saikosaponin A (SSA), a promising natural metabolite characterized low toxicity, demonstrating efficacy against breast through induction of cellular senescence. The antitumor property SSA was determined via MTT colorimetric assay, 5-ethynyl-2'-deoxyuridine (EdU) incorporation colony formation, and propidium iodide (PI) staining in...
The MYH11 gene may be related to cell migration and adhesion, intracellular transport, signal transduction. However, its relationship with prognosis is still uncertain. aim of this study was investigate correlations between expression in 58 patients stage II III colorectal cancer. Quantitative real-time polymerase chain reaction performed fresh CRC tissues examine mRNA expression, immunohistochemistry paraffin-embedded specimens for protein expression. On univariate analysis, at both levels,...
Three new phenolic compounds 1–3 and twenty known ones 4–23 were isolated from the flowers of Bombax malabaricum. Their chemical structures elucidated by spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D- 2D-NMR) reactions. The antioxidant capacities tested using FRAP DPPH radical-scavenging assays, 4, 6, 8, 12, as well compound 2, exhibited stronger activities than ascorbic acid. Furthermore, all for their antiviral against RSV CPE reduction assay plaque assay. Compounds 10, 12 possess in...
Thus far, the impact of kaolin mining activities on surrounding native plants and rhizosphere microecology has not been fully understood.
Myocardial ischemia-reperfusion injury (MI/RI) is a critical challenge for acute myocardial infarction therapy, as there currently no ideal drug available. Glycogen synthase kinase 3 beta (GSK-3β) serves an promising therapeutic target treating MI/RI. Our previous studies have demonstrated that Ilex pubescens ameliorates The purpose of this study to evaluate the efficacy and potential mechanism screened GSK-3β inhibitor from against Three-dimensional-quantitative structure-activity...
Introduction The plant restoration and ecological of lead-zinc mines are very important. Methods In this study, we used three local plants to carry out abandoned lead–zinc mining areas detected the adaptive mechanisms soil bacterial diversity function during through 16S rRNA sequencing. Results results revealed that significantly reduced diversity, including Shannon, Simpson, observed species indices, whereas planting restored microbial a certain extent, leading increases in Shannon index...
Background The outbreak of Coronavirus disease 2019 (COVID-19) has become an international public health crisis, and the number cases with dengue co-infection raised concerns. Unfortunately, treatment options are currently limited or even unavailable. Thus, aim our study was to explore underlying mechanisms identify potential therapeutic targets for co-infection. Methods To further understand co-infection, we used a series bioinformatics analyses build host factor interaction networks...
Primary acinar cell carcinoma (ACC) is a rare exocrine tumor of the pancreas with unclear clinical characteristics. Our goal was to determine incidence and update characteristics outcomes ACC.Through Surveillance, Epidemiology, End Results (SEER) database, we identified 252 patients latest diagnosis ACC (2004-2016). The age-adjusted (AAI) calculated using SEER*Stat Software version 8.3.6. Kaplan-Meier method used draw survival curves differences among them were compared by log-rank test. Cox...