A5100647178- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Gastrointestinal Tumor Research and Treatment
- GDF15 and Related Biomarkers
- Macrophage Migration Inhibitory Factor
- Enhanced Recovery After Surgery
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Advanced Neuroimaging Techniques and Applications
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Nuclear Receptors and Signaling
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Parathyroid Disorders and Treatments
- Gut microbiota and health
- Colorectal Cancer Treatments and Studies
- Sarcoma Diagnosis and Treatment
- Diet and metabolism studies
- FOXO transcription factor regulation
- Radiomics and Machine Learning in Medical Imaging
Fudan University Shanghai Cancer Center
2013-2020
Shanghai Medical College of Fudan University
2013-2020
Fudan University
2020
Color (United States)
2020
University of Michigan
2012
Abstract Long noncoding RNAs (lncRNAs) have been revealed to play critical roles in tumor initiation and progression. The antisense lncRNA LDLRAD4-AS1 is the longest of LDLRAD4, its expression levels, cellular localization, precise function, mechanism colorectal cancer (CRC) remain unknown. In this study, we observed that was located nucleus CRC cells upregulated most specimens cell lines. Overexpression correlated with poor prognosis patients. LncRNA upregulation enhanced migration invasion...
Growth arrest-specific 1 (Gas1) plays a critical role in growth suppression. Previous study indicated that Gas1 was closely associated with survival patients colorectal cancer; however, the underlying molecular mechanism remains unclear. In this study, we sought to determine of tumorigenesis and metastasis, elucidate possible mechanism. First, determined as negative regulator oncogenesis metastasis cancer. Mechanistically, negatively regulated aerobic glycolysis, process contributed tumor...
Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress activates unfolded protein response pathways, which drives GDF15 expression cancer cells. Mechanistically, upregulated CHOP led by activated PERK-eIF2α signaling promotes transcription via directly binding to its promoter....
Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified a tumor gene in variety of cancers, including colorectal cancer. Recent years have witnessed the importance metabolism transformation cancer cell malignancies maintenance. Aberrant is considered to be hallmark Our previous studies demonstrated that KL played negative roles colon proliferation metastasis. However, its role reprogramming seldom reported. The aim this study examine aerobic glycolysis...
<div>Abstract<p><b>Purpose:</b> The early detection of colorectal cancer (CRC) is crucial for successful treatment and patient survival. However, compliance with current screening methods remains poor. This study aimed to identify an accurate blood-based gene expression signature CRC detection.</p><p><b>Experimental Design:</b> Gene in peripheral blood samples from 216 patients tumors 187 controls was investigated the study. We first conducted...
<p>Supplementary Figure 1: miRNAs in the parental cells with those of MDR colorectal cancer using miRNA microarray.</p>
<p>Supplementary Figure 4: miR-200c modifies the chemo-drug sensitivity of HCT116/MDR cells and growth activity.</p>
<p>Supplementary Figure 4: miR-200c modifies the chemo-drug sensitivity of HCT116/MDR cells and growth activity.</p>
<p>Supplementary Figure 2: Relative expression levels of miR-200c in MDR cells and their parental cells.</p>
Background: Notch signaling pathway plays a crucial role in progression of colorectal cancer (CRC).Genetic variants genes may impact the prognosis CRC.Method: The associations genotypes single-nucleotide polymorphisms (SNPs) from and overall survival (OS) 1116 Chinese eastern CRC were investigated. ChIP sequencing data encyclopedia DNA Elements (ENCODE), Expression quantitative trait loci (eQTL) analysis Dual luciferase assays used to evaluated association SNPs genotype candidate gene...