A5100348687- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Diabetes Treatment and Management
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Vibrio bacteria research studies
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- Hip disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Antibiotic Resistance in Bacteria
- Orthopaedic implants and arthroplasty
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Escherichia coli research studies
- Pharmacology and Obesity Treatment
- Pharmaceutical Practices and Patient Outcomes
Chinese Academy of Agricultural Sciences
2023-2025
Nanjing Medical University
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Institute of Hematology & Blood Diseases Hospital
2025
Children's Hospital of Fudan University
2009-2025
Nanjing Drum Tower Hospital
2024-2025
Wuhan University
2016-2025
Shandong Provincial QianFoShan Hospital
2019-2025
Tongji University
2016-2025
Xiangya Hospital Central South University
2025
// Hao Li 1 , Beiqin Yu Jianfang Liping Su Min Yan Zhenggang Zhu Bingya Liu Shanghai Key Laboratory of Gastric Neoplasms, Institute Digestive Surgery, Ruijin Hospital, Jiao Tong University School Medicine, 200025, People’s Republic China. Correspondence: Liu, email: Keywords : gastric cancer, long non-coding RNA, H19, microRNA, miR-675 Received March 04, 2014 Accepted April 16, Published 18, Abstract Long RNAs (lncRNAs) play key roles in the progression and metastasis some carcinomas....
Abstract Developing superporous hemostatic sponges with simultaneously enhanced permeability and mechanical properties remains challenging but highly desirable to achieve rapid hemostasis for non-compressible hemorrhage. Typical approaches improve the of by increasing porosity sacrifice yield limited pore interconnectivity, thereby undermining efficacy subsequent tissue regeneration. Herein, we propose a temperature-assisted secondary network compaction strategy following phase...
Given the global surge in autoimmune diseases, it is critical to evaluate emerging therapeutic interventions. Despite numerous new targeted immunomodulatory therapies, comprehensive approaches apply and effects of these treatments longitudinally are lacking. Here, we leveraged advances programmable-phage immunoprecipitation methodology explore modulation, or lack thereof, autoantibody profiles, proteome-wide, both health disease. Using a custom set over 730,000 human-derived peptides,...
The consequences of the lack apolipoprotein A-I (apoA-I) were evaluated in mice made to apoA-I by gene targeting. Inbred strain 129 homozygous for inactive Apoa1 and maintained on regular mouse chow had markedly reduced total cholesterol (26% normal) high-density lipoprotein (HDL) (25% levels their plasma. Their plasma lipoproteins lacked all other apolipoproteins but apoE. ApoE comprises about one third protein HDL particles homozygotes, whereas it is present only trace amounts normal HDL....
Abstract The imbalance of Th17/Treg cell populations has been suggested to be involved in the regulation rheumatoid arthritis ( RA ) pathogenesis; however, mechanism behind this phenomenon remains unclear. Recent studies have shown how micro RNA s (mi s) are important regulators immune responses and development a variety inflammatory diseases, including . In study, we demonstrated that frequencies CD 3 + 4 IL ‐17 Th17 cells were significantly higher, 25 FOXP Treg lower peripheral blood...
BACKGROUNDSystemic inflammation and nutrition status play an important role in cancer metastasis.The combined index of hemoglobin, albumin, lymphocyte, platelet (HALP), consisting haemoglobin, lymphocytes, platelets, is considered as a novel marker to reflect both systemic status.However, no studies have investigated the relationship between HALP survival patients with pancreatic following radical resection. AIMTo evaluate prognostic value preoperative patients.Program Shanghai.
Abstract Purpose: Constitutive NF-κB activation is identified in about 70% of pancreatic ductal adenocarcinoma (PDAC) cases and required for oncogenic KRAS-induced PDAC development mouse models. We sought to determine whether targeting IL-1α pathway would inhibit activity thus suppress cell growth. Experimental Design: determined anakinra, a human IL-1 receptor (rhIL-1R) antagonist, inhibited activation. Assays proliferation, migration, invasion were performed with rhIL-1R antagonist using...
The skeletal system contains a series of sophisticated cellular lineages arising from the mesenchymal stem cells (MSCs) and hematopoietic (HSCs) that determine homeostasis bone marrow. Here, we reasoned osteocyte may exert function in regulation these lineage cell specifications tissue homeostasis. Using mouse model conditional deletion osteocytes by expression diphtheria toxin subunit α dentin matrix protein 1 (DMP1)-positive osteocytes, demonstrated partial ablation DMP1-positive caused...
The blood-brain barrier (BBB) acts as the crucial physical filtration structure in central nervous system. Here, we investigate role of a specific subset astrocytes regulation BBB integrity. We showed that Dmp1- expressing transfer mitochondria to endothelial cells via their endfeet for maintaining Deletion Mitofusin 2 ( Mfn2 ) gene Dmp1 -expressing inhibited mitochondrial and caused leakage. In addition, decrease MFN2 contributes age-associated reduction efficiency thus compromises...
Abstract Interactions between osteolineage cells and myeloid play important roles in maintaining skeletal homeostasis. Herein, we find that transfer mitochondria to cells. Impairment of the by deleting MIRO1 leads increased cell commitment toward osteoclastic lineage promotes bone resorption. In detail, impaired mitochondrial from alters glutathione metabolism protects ferroptosis, thus promoting osteoclast activities. Furthermore, is involved regulation glucocorticoid-induced osteoporosis,...
The purposes of this study were to determine the expression profiles microRNA-34a (miR-34a) in human gastric cancer cell line (SGC-7901) and cisplatin-resistant lines (SGC-7901/DDP), establish correlation between miR-34a profile sensitivity cisplatin-based pattern, thereby providing new methods strategies for treating cancer. Gastric (SGC-7901/DDP) cultivated vitro, respectively. Quantitative real-time PCR (qRT-PCR) Western blot utilized survivin both lines. With mimic inhibitor transfected...
Elevated MELK expression is featured in multiple tumors and correlated with tumorigenesis tumor development. This study aimed to investigate the mechanisms of MELK-mediated development gastric cancer. levels human cancer were determined by quantitative-PCR immunohistochemistry. The effect on cell activity was explored knockdown overexpression experiments. Cell growth measured using CCK-8 assay. Apoptosis cycle distributions analyzed flow cytometry. Migration invasion tested a transwell...
Current treatment of intrahepatic cholangiocarcinoma (ICC) remains ineffective because knowledge ICC carcinogenesis is unclear. Increasing evidence suggests that microRNAs (miRNAs), including miR‐191, play an important role in tumorigenesis; but expression and biological functions miR‐191 remain to be established. This study investigated the underlying mechanisms ICC. miRNA profiles were generated five pairs matched normal bile duct tissues by next‐generation sequencing technology; verified...
We aimed to investigate the expression of microRNA-34a (miR-34a) in human gastric cancer cells and evaluate effects miR-34a, acting via its gene survivin, on cell HGC-27 provide potential new strategies for treating cancer. In vitro cultures lines MGC80-3, HGC-27, NCI-N87, SGC-7901 normal epithelial line GES-1 were established. The miR-34a each was detected using quantitative real-time polymerase chain reaction (qRT-PCR). After transfected with a mimic 48 h, changes levels qRT-PCR. effect...
Bacterial Rhs proteins containing toxic domains are often secreted by type VI secretion systems (T6SSs) through unclear mechanisms. Here, we show that the T6SS Rhs-family effector TseI of Aeromonas dhakensis is subject to self-cleavage at both N- and C-terminus, releasing middle core two VgrG-interacting (which name VIRN VIRC). VIRC an endonuclease, immunity protein TsiI protects against toxicity direct interaction. Proteolytic release mediated, respectively, internal aspartic protease...
Calcineurin B-like interacting protein kinases (CIPKs) play important roles via environmental stress. However, less is known how to sense the stress in molecular structure conformation level. Here, an OsCIPK7 mutant TILLING procedure with a point mutation kinase domain showed increased chilling tolerance, which could be potentially used breeding. We found that this of led conformational change activation loop domain, subsequently increase activity, thus conferred tolerance
Abstract The type VI secretion system (T6SS) is a double‐tubular nanomachine widely found in gram‐negative bacteria. Its spear‐like Hcp tube capable of penetrating neighboring cell for cytosol‐to‐cytosol protein delivery. However, gram‐positive bacteria have been considered impenetrable to such T6SS action. Here we report that the plant pathogen, Acidovorax citrulli (AC), could deliver an Rhs‐family nuclease effector RhsB kill not only but also Using bioinformatic, biochemical, and genetic...
Background Upper limb intelligence robots are widely used to improve the upper function of patients with stroke, but treatment mechanism is still not clear. In this study, functional near-infrared spectroscopy (fNIRS) was evaluate concentration changes oxygenated hemoglobin (oxy-Hb) and deoxyhemoglobin (deoxy-Hb) in different brain regions connectivity (FC) cerebral cortex stroke. Method Twenty post-stroke dysfunction were included study. They all received three types shoulder joint...