A5074438850- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- HIV Research and Treatment
- Renal cell carcinoma treatment
- Parathyroid Disorders and Treatments
- Polyomavirus and related diseases
- Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Vitamin D Research Studies
- Cutaneous Melanoma Detection and Management
- Cellular Mechanics and Interactions
- Intraperitoneal and Appendiceal Malignancies
BC Cancer Agency
2022-2025
Vancouver General Hospital
2019-2024
University of British Columbia
2005-2024
McMaster University
2024
Ottawa Hospital Research Institute
2024
Alberta Health
2024
Ottawa Hospital
2024
University of Calgary
2013-2022
University of Miami
2016-2022
Ragon Institute of MGH, MIT and Harvard
2019-2021
Primary tumor resection and mesenteric lymph node dissection in asymptomatic patients with stage IV small intestinal neuroendocrine tumors (SI-NETs) are controversial.To determine the association of locoregional surgery (LRS) performed at diagnosis outcomes SI-NETs distant metastases.This cohort study included diagnosed from January 1, 1985, through December 31, 2015, identified using prospective database Uppsala University Hospital, Uppsala, Sweden. Patients were treated a tertiary referral...
In Brief OBJECTIVE: To assess the incidence of combined adverse maternal and perinatal outcomes in women with preeclampsia before after introducing standardized assessment surveillance. METHODS: This study was a preintervention (retrospective) compared postintervention (prospective) cohort comparison single-tertiary, unit that included admitted to hospital preeclampsia. We interrogated an existing retrospective 24-month database then introduced guidelines, assessing for 41 months (September...
The pseudopodial protrusions of Moloney sarcoma virus (MSV)-Madin-Darby canine kidney (MDCK)-invasive (INV) variant cells were purified on 1-microm pore polycarbonate filters that selectively allow passage the domains but not cell body. fraction contains phosphotyrosinated proteins, including Met and FAK, various signaling Raf1, MEK1, ERK2, PKBalpha (Akt1), GSK3alpha, GSK3beta, Rb, Stat3. Pseudopodial proteins identified by liquid chromatography tandem mass spectrometry included actin...
mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, deregulated control of is tumor malignancy. We show here that activated RhoA, but not Rac1, enriched in pseudopodia MSV-MDCK-INV cells Rho, Rho kinase (ROCK), myosin II regulate the microtubule-independent targeting RNA to these cell domains. ROCK inhibition does affect pseudopodial actin turnover significantly reduces dynamics turnover. Gene array analysis shows...
Cavernous hemangiomas of the adrenal gland are rare. We report a case cavernous hemangioma presenting as an incidentaloma suspicious for cortical carcinoma (ACC).A 78 year old woman was admitted after fall. Abdominal computed tomography revealed large right lesion with features (5.4cm×3.3cm, unilateral, tumor calcifications, average Hounsfield units 55). The removed intact by laparoscopic approach and pathology gland.Adrenal incidentalomas found in up to 10% patients undergoing abdominal...
Background: The incidence of colorectal cancer (CRC) is decreasing in individuals >50 years due to organised screening but has increased for younger individuals. We characterized symptoms and their timing before diagnosis young Methods: identified all patients diagnosed with CRC between 1990–2017 British Columbia, Canada. Individuals <50 (n = 2544, EoCRC) a matched cohort 2570, LoCRC) underwent chart review identify related at determine time from symptom onset diagnosis. Results:...
Desmoid tumors are locally destructive but histologically benign. Their management involves close observation and surgical, medical, or hormonal treatment.A 36-year-old male was admitted for abdominal pain fever. A CT scan showed fluid collections air within a mesenteric mass. Diagnostic laparotomy performed with drainage of the abscess biopsy The pathology suggested desmoid tumor. His fever persisted. An endoscopy performed, which demonstrated fistula track in third part duodenum. After...
It is unclear whether parathyroidectomy guided by intraoperative parathormone (PTH) monitoring predictive of operative success in patients with normohormonal hyperparathyroidism (nhHPT), a variant primary (pHPT) which develop clinical manifestations similar to those pHPT. This study examined PTH undergoing for nhHPT.We performed retrospective review prospectively collected data from adult (age > 18 yr) who underwent pHPT at 1 2 North American medical centres (in Calgary, Alberta, Canada, or...
The objective of this study was to evaluate the safety and effectiveness transanal endoscopic microsurgery for rectal neuroendocrine tumours.A retrospective cohort all pathology-confirmed tumours treated by from April 2007 December 2020 at a tertiary care centre performed. Demographic, clinical, radiographic pathological data were collected. Characteristics patients with recurrence examined. Descriptive statistics performed.There 58 excision. Referrals primary excision (15, 25.9%),...
451 Background: FOLFIRINOX or Gemcitabine+nab-Paclitaxel (Gem/nPac) has superior overall survival (OS) compared with gemcitabine alone in pts Stage 4 pancreatic cancer (PC). Based on these results, Gem/nPac been utilized neoadjuvant (NA) setting for BR and LA PC. This report describes our multi-institutional experience NA treatment followed by surgical resection. Methods: Pts PC who received underwent resection between 2011 2015 at 7 high volume pancreas centers were reviewed. Pre-operative...
Abstract Background Rectal neuroendocrine tumors (RNETs) are often discovered on screening colonoscopy. Indications for staging and definitive resection inconsistent in current guidelines. We evaluated the role of grade guiding procedural decision-making. Methods Patients with biopsy confirmed RNETs between 2004 2015 were reviewed. Baseline characteristics, investigations (biochemical imaging), endoscopic/surgical treatment recorded. Associations grade, preoperative staging, interventions,...
Importance Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. Due to its relatively low incidence and limited prospective trials, current recommendations are guided by historical single-institution retrospective studies. Objective To evaluate the overall survival (OS) of patients in Canada with head neck MCC (HNMCC) according American Joint Committee on Cancer 8th edition staging treatment modalities. Design, Setting, Participants A cohort study 400 a diagnosis...
Abstract Octreotide LAR is a long‐acting somatostatin analogue (SSA) used in the management of metastatic gastroenteropancreatic neuroendocrine tumors (GEP NETs). It requires intramuscular (IM) injection. Missed IM injections cause subcutaneous nodules (SCNs) on radiologic images. We reviewed rates SCNs real‐world cohort GEP NETs receiving octreotide and explored treatment outcomes. Patients commencing between August 5, 2010 March 8, 2018 at single cancer center Canada were identified from...
A 45-year-old female presents with suspected acute myocardial infarction cardiogenic shock requiring mechanical circulatory support. Pheochromocytoma-induced atypical Takotsubo syndrome is diagnosed. Clinicians should suspect high catecholamine states as a cause of the basal subtype syndrome. (Level Difficulty: Beginner.)
Sentinel lymph node biopsy (SLNB) for melanoma plays a central role in determining prognosis and guiding treatment surveillance strategies. Despite widely published guidelines SLNB, variation exists its use. We aimed to determine the frequency of predictive factors SLNB patients with clinically node-negative British Columbia.A retrospective review was performed diagnosed between January 2015 December 2017. Patients included had Breslow depth greater than 0.75 mm or less equal ulceration,...
Objectives We evaluated a population-based cohort of metastatic well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors (G3 NETs) to describe their characteristics, prognosis, and treatment outcomes. Methods The British Columbia provincial database was queried for G3 NETs diagnosed 2004 2021, charts were reviewed clinical features Results Forty-one patients identified, most with pancreatic (58.5%) or midgut (26.8%) primary tumor Ki-67 less than 55% in 68.3%. resected 19...