A5046757384- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Diabetes Treatment and Management
- Diabetes Management and Education
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Hormonal and reproductive studies
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Spinal Hematomas and Complications
- IL-33, ST2, and ILC Pathways
- Natural Products and Biological Research
- Bone health and osteoporosis research
- Adrenal and Paraganglionic Tumors
- Neurosurgical Procedures and Complications
- Liver Diseases and Immunity
- Venous Thromboembolism Diagnosis and Management
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Hepatitis B Virus Studies
- Diabetic Foot Ulcer Assessment and Management
- Hepatitis C virus research
University of British Columbia
2014-2022
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2020
Université Laval
2017-2018
Vancouver General Hospital
2018
McGill University Health Centre
2010
Studies of long-standing type 2 diabetes (T2D) report a deficit in β-cell mass due to increased apoptosis, whereas neogenesis and replication are unaffected. It is unclear whether these changes cause or consequence T2D. Moreover, islet morphogenetic plasticity has been demonstrated vitro, the situ islets, as well effect T2D on endocrine differentiation, unknown. We compared volume, neogenesis, replication, apoptosis pancreata from lean obese (body index ≥ 27 kg/m2) diabetic (5 ± yr since...
Obesity has reached epidemic proportions and is often accompanied by elevated levels of pro-inflammatory cytokines that promote many chronic diseases, including cancer. However, not all obese people develop these diseases it would be very helpful to identify those at high risk early on so preventative measures can instituted. We performed an extensive evaluation the effects obesity inflammatory markers, innate adaptive immune responses, blood cell composition markers might useful in...
To define standard criteria for the detection of lipohypertrophy using ultrasonography and to determine accuracy this method.Individuals insulin therapy ≥2 years with unknown status were enrolled at a diabetes education centre. A team educator nurses performed clinical examination evidence separate ultrasonographers examined participants in blinded fashion.The echo signature consisted location subcutaneous layer lesions that 1) well circumscribed either by hyperechoic foci defined borders or...
BACKGROUND: Hepatitis B virus (HBV) and hepatitis C (HCV) represent an increasing health burden morbidity in Canada. Viral hepatitis, specifically HCV, has high prevalence among persons born between 1945 1965, with 45% to 85% of infected adults asymptomatic unaware their infection. Screening been shown be cost effective the detection treatment viral hepatitis. OBJECTIVE: To quantify incidence identify undocumented HBV HCV infection hospitalized patients at a single centre secondary analysis...
A 45-year-old female presents with suspected acute myocardial infarction cardiogenic shock requiring mechanical circulatory support. Pheochromocytoma-induced atypical Takotsubo syndrome is diagnosed. Clinicians should suspect high catecholamine states as a cause of the basal subtype syndrome. (Level Difficulty: Beginner.)
The most common dermatological complication of insulin therapy is lipohypertrophy.As a proof concept, we built and tested an automated model using convolutional neural network (CNN) to detect the presence lipohypertrophy in ultrasound images.Ultrasound images were obtained blinded fashion portable GE LOGIQ e machine with L8-18I-D probe (5-18 MHz; Healthcare). data split into train, validation, test splits 70%, 15%, respectively. Given small size set, image augmentation techniques used expand...
ABSTRACT The sexual dimorphism in human body fat distribution suggests a causal role for sex hormones. This is of particular importance when considering the excess visceral adipose tissue accumulation as critical determinant obesity‐related cardiometabolic alterations. Scientific literature on modulation by androgens humans abundant, remarkably inconsistent and difficult to summarize. We reviewed relevant this topic, with emphasis androgen replacement, effects selected parameters function...
Abstract Background: Insulinoma is the most common neuroendocrine tumor (NET), occurring in 1-4 people per million. Surgical resection remains standard of care for symptomatic control and long-term remission. Where surgery not feasible medical therapy with diazoxide somatostatin analogues used as supportive management. Case: A 88-year-old male background hypertension, remote myocardial infarct chronic kidney disease (CKD) (Cr 130-150 umol/L; N 60-115) was diagnosed insulinoma following a...
Objective: Using a supervised machine learning convolutional neural network (CNN) we developed model to detect lipohypertrophy (LH) using point-of-care ultrasound (PoCUS) images. Research Designs and Methods: PoCUS (GE LOGIQe, 5-18 MHz probe), images were obtained by single, blinded technician. We then split the data set into training (70%), validation (15%) testing splits. To improve generalizability of model, used image augmentation techniques (randomly changing contrast, brightness, etc)....
The FreeStyle Libre flash glucose monitoring (FGM) system was introduced in Canada 2017. FGM incorporates aspects of conventional blood testing and continuous (CGM). utilizes a sensor placed on the upper arm to test interstitial levels every fifteen minutes may be used obtain ‘flash’ (real-time) reading. is less costly than CGM help overcome common barriers testing, including pain, needle aversion, inconvenience, but at present there no public coverage for product available Canada. In this...
Hybrid closed-loop (HCL) insulin pump therapy is a promising development for the management of type 1 diabetes (T1D), but little known about transition period to HCL in real-world setting. Here, we present novel data evaluating experience and its effect on distress. We evaluated 32 out 150 anticipated participants who were (Arm A), or had recently transitioned B), from standard MiniMed™ 670G pump. Patients completed baseline 6-month post-transition distress survey using T1-DDS. In follow-up...
<sec> <title>BACKGROUND</title> The most common dermatological complication of insulin therapy is lipohypertrophy. </sec> <title>OBJECTIVE</title> As a proof concept, we built and tested an automated model using convolutional neural network (CNN) to detect the presence lipohypertrophy in ultrasound images. <title>METHODS</title> Ultrasound images were obtained blinded fashion portable GE LOGIQ <i>e</i> machine with L8-18I-D probe (5-18 MHz; Healthcare). data split into train,...