A5083473885- Cardiac Ischemia and Reperfusion
- Biosensors and Analytical Detection
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Signaling Pathways in Disease
- Tryptophan and brain disorders
- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- Circular RNAs in diseases
- ATP Synthase and ATPases Research
- Stress Responses and Cortisol
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- Heart Failure Treatment and Management
- Medicinal Plants and Neuroprotection
- Phytochemical Studies and Bioactivities
- Macrophage Migration Inhibitory Factor
Guangzhou University of Chinese Medicine
2018-2025
East China University of Technology
2025
Anhui University of Technology
2025
Ministry of Education of the People's Republic of China
2019-2025
Jiujiang University
2025
Institute of Genetics and Developmental Biology
2025
Center for Agricultural Resources Research
2025
Chinese Academy of Sciences
2024-2025
University of Chinese Academy of Sciences
2024-2025
Huashan Hospital
2025
Macrophage polarization is implicated in the inflammation obesity.The aim of present study was to examine anti-inflammatory activities botanical triterpene celastrol against diet-induced obesity.We treated obese C57BL/6N male mice with (5, 7.5 mg/kg/d) for 3 weeks, and investigated macrophage M1/M2 adipose hepatic tissues.Celastrol reduced fat accumulation ameliorated glucose tolerance insulin sensitivity.Celastrol down-regulated mRNA levels M1 biomarkers (e.g., IL-6, IL-1β, TNF-α, iNOS)...
Excessive intake of estrogen poses significant health risks to the human body; hence, there is a necessity develop rapid detection methods monitor its levels addition. Gold nanoparticles (AuNPs), commonly utilized as colorimetric signal labels, find extensive application in lateral flow immunoassay (LFIA). However, sensitivity traditional AuNPs-LFIA typically constrained by low molar extinction coefficients and reliance on single signal. Herein, this work, unique spark-type AuCuPt...
Tuberculous pleural effusion (TPE) is a challenging extrapulmonary manifestation of tuberculosis, with traditional diagnostic methods often involving invasive surgery and being time-consuming. While various machine learning statistical models have been proposed for TPE diagnosis, these are typically limited by complexities in data processing difficulties feature integration. Therefore, this study aims to develop model using ChatGPT-4, large language (LLM), compare its performance logistic...
Abstract Glycolytic reprogramming of macrophages is a decisive factor in atherosclerosis (AS) plaque formation. Eukaryotic elongation 1A1 (eEF1A1) plays an important role protein synthesis, ubiquitination degradation, and nuclear translocation. However, the potential function eEF1A1 AS has not yet been fully understood. Here, natural small molecule neferine (Nef), which targets to suppress macrophage glycolytic discovered. In this work, chemical genetics non‐modified target confirmation...
Oxidative stress plays a significant role in exacerbation of asthma. The vitamin D oxidative and asthma remains unclear. We aimed to determine the relationship between status exacerbation. Severe patients with 25-hydroxyvitamin D3-deficiency (V-D deficiency) or D-sufficiency sufficiency) were enrolled. V-D-deficiency showed lower forced expiratory volume one second (FEV1) compared that V-D-sufficiency. intensified ROS release DNA damage increased TNF-α, OGG1 NFκB expression phosphorylation...
Background and Purpose: Kelch ECH-associating protein 1 (Keap1) is a crucial chaperonin for E3 ubiquitin ligases. Modification of the key reactive cysteine residues in Keap1 affects interaction between its substrate nuclear factor erythroid 2-related 2 (Nrf2), subsequently regulating oxidative stress NLPR3 inflammasome activation, which are important factors myocardial ischemia-reperfusion injury (MI/RI). Pubescenoside A (PBA), an active compound from Ilex pubescens, has antithrombotic...
The opening of mitochondrial permeability transition pore (mPTP) is a major cause cell death in ischemia reperfusion injury. Based on our pilot experiments, plant natural product formononetin enhanced the survival rat cardiomyocyte H9c2 cells during oxygen glucose deprivation (OGD) and reoxygenation. For mechanistic studies, we focused two cellular factors, namely, reactive species (ROS) glycogen synthase kinase 3 β (GSK‐3 ), regulation mPTP opening. We found that suppressed formation ROS...
Alkaloids from <italic>lotus plumule</italic> regulated BDNF-mediated ER stress and autophagy, subsequently attenuating neuroinflammation in LPS-stimulated BV2 microglia LPS-induced depressive C56BL/6N mice.