A5101627886- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Cancer Research and Treatments
- Respiratory Support and Mechanisms
- Signaling Pathways in Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Obstructive Sleep Apnea Research
- Biochemical effects in animals
- Ferroptosis and cancer prognosis
- Sirtuins and Resveratrol in Medicine
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
Fudan University
2007-2025
Second Affiliated Hospital of Nanjing Medical University
2014-2024
Anhui Medical University
2024
Second Hospital of Anhui Medical University
2024
Heilongjiang Provincial Academy of Agricultural Sciences
2023
First Affiliated Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Zhejiang University
2023
Shanghai Medical College of Fudan University
2007-2021
Binzhou University
2020
Abstract Purpose: Besides its therapeutic effects, chemotherapeutic agents also enhance the malignancy of treated cancers in clinical situations. Recently, epithelial-mesenchymal transition (EMT) has attracted attention studies tumor progression. We aimed to test whether transient Adriamycin treatment induces EMT and apoptosis simultaneously cancer cells, clarify why same type cells responds differentially (i.e., apoptosis, EMT) treatment, elucidate role Twist1, master regulator EMT, this...
Coronavirus disease 2019 (COVID-19) has spread worldwide. To date, no specific drug for COVID-19 been developed. Thus, this randomized, open-label, controlled clinical trial (ChiCTR2000029853) was performed in China. A total of 20 mild and common patients were enrolled randomly assigned to receive azvudine symptomatic treatment (FNC group), or standard antiviral (control group). The mean times the first nucleic acid negative conversion (NANC) ten FNC group control are 2.60 (SD 0.97; range...
Abstract Setaria italica (foxtail millet), a founder crop of East Asian agriculture, is model plant for C4 photosynthesis and developing approaches to adaptive breeding across multiple climates. Here we established the pan-genome by assembling 110 representative genomes from worldwide collection. The composed 73,528 gene families, which 23.8%, 42.9%, 29.4% 3.9% are core, soft dispensable private genes, respectively; 202,884 nonredundant structural variants were also detected....
Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1. We find that loss of YAP expression key for SCLC cells acquire rapid ameboid migration high metastatic potential. functions through target genes CCN1/CCN2 inhibit migration. RB1 mutation contributes transcriptional silencing via E2F7, which recruits the RCOR co-repressor complex promoter. discover benzamide family HDAC inhibitors stimulate by inhibiting...
Hypoxia-inducible factor 2α (HIF2α) antagonists are effective against clear cell renal carcinomas (ccRCCs) that highly express HIF2α. To identify potential drug targets in HIF2α low/− ccRCC, we constructed an epigenetic-focused single-guide RNA library and performed vivo CRISPR-Cas9 knockout screen BALB/c nude mice transplanted with 786-O (HIF2α high ) or Caki-2 cells. We found the m6A demethylase fat mass obesity-associated ( FTO gene was indispensable to growth of but not ccRCC. Activation...
Abstract We aimed to investigate the expression of RACK1 in breast cancer, evaluate its role predicting prognosis and compare with commonly used biomarkers: Ki67, ER, PR HER‐2 for patients cancer. The clinical significance were examined 160 carcinoma using immunohistochemistry. Correlations other biomarkers survival analyses assessed. Immunohistochemistry results showed that number cases scoring 0, 1, 2 66, 54, 40, respectively. staining was strongly related stage, histological grade, (all p...
Multidrug resistance (MDR) is one of the most important factors leading to chemotherapeutic failure in patients with breast cancer. The invasive/metastatic ability MDR cells strengthened compared their parental cells. However, mechanisms underlying have not been fully elucidated. We found that CD44 and cellular prion protein (PrPc) were both overexpressed (MCF7/Adr H69AR). Subsequently, we chose human cancer cell line MCF7/Adr, which resistant adriamycin, for further research. discovered...
Highlights•Sirt5+ subset in wild-type Kras colorectal tumors determines multidrug resistance•Sirt5-mediated demalonylation and inactivation of SDHA lead to succinate accumulation•Succinate binds activates TrxR2 maintain chemotherapy resistance•Succinate inhibits aKG-dependent dioxygenases regulate cetuximab resistanceSummaryA major obstacle for successful management patients with carcinoma (CRC) is resistance anti-cancer cytotoxic treatments. Here, we identified a mechanism CRCs based on the...
Cellular prion protein (PrPc) is a glycosylphosphatidylinositol-anchored membrane that has various physical functions, including protection against apoptotic and oxidative stress, cellular uptake of copper ions, transmembrane signaling, adhesion to the extracellular matrix. In this study, we show PrPc highly expressed in colorectal adenocarcinomas. Transcriptome profiling PrPc-depleted DLD-1 cells revealed downregulation glucose transporter 1 (Glut1). shown be involved regulating Glut1...
Glioma is a common life-threatening tumor with high malignancy and invasiveness. LncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) was confirmed to be implicated in numerous tumors, while its biological function mechanism have not been thoroughly understood glioma. The gene expression measured by RT-qPCR. Cell proliferation, cell cycle, apoptosis of glioma cells were validated CCK-8, colony formation, flow cytometry TUNEL assays. effect ZFPM2-AS1 on growth verified vivo assay. exploration...
Multidrug resistant (MDR) cancer cells overexpressing P‐glycoprotein (P‐gp) display variations in invasive and metastatic behavior. We aimed to clarify the mechanism(s) underlying this observation transfected vectors carrying CD147, a glycoprotein enriched on surface of tumor that stimulates production matrix metalloproteinases (MMPs), specific shCD147 into MCF7 MCF7/Adr cells, respectively. Using quantitative real‐time polymerase chain reaction Western blot, we found overexpression CD147...
Treatment of animals bearing multidrug resistant (MDR) tumor cells with P‐glycoprotein (P‐gp) substrates could worsen host survival. It is assumed that this due to increased metastasis. To clarify the mechanism(s) underlying observation, MDR human breast cancer cell line, MCF‐7/AdrR, and its sensitive parental MCF‐7, was treated various concentrations P‐gp substrate drugs (vincristine, paclitoxel, adriamycin) a non‐substrate drug (bleomycin) in serum‐free media. Increased production CD147,...
Special AT-rich sequence binding protein (SATB) 1 has been proposed to act as a determinant for the acquisition of metastatic activity by controlling expression specific set genes that promote activity. Here we found SATB1 is upregulated in multidrug-resistant breast cancer cells exhibit higher invasive potential than parental cells. Apart from accelerating metastasis and inducing epithelial-mesenchymal transition, was demonstrated confer resistance both P-glycoprotein-related...
Abstract Circulating miRNAs have attracted attention as serum biomarkers for several diseases. In this study, we aimed to evaluate the diagnostic value of circulating miRNA-21 (miR-21) a novel biomarker elderly patients with type 2 cardiorenal syndrome (CRS-2). A total 157 chronic heart failure (CHF) were recruited study. According an estimated glomerular filtration rate (eGFR) cut-off 60 ml/min/1.73 m , 84 (53.5%) and 73 (46.5%) assigned CRS group CHF group, respectively. Expression levels...
Senkyunolides are a group of phthalide molecules that exist in Umbelliferae plants, with the highest abundance Ligusticum chuanxiong Hort, medicinal herb therapeutic applications various diseases such as coronary heart disease, migraine, and rheumatism. Modern research has highlighted anti-inflammatory, analgesic, cardiovascular-protective properties senkyunolides. Recently, some novel effects, antibacterial, anti-osteoporosis, anti-fibrosis, have been reported for senkyunolides, indicating...
Abstract The objective of this study was to explore the positive influence and potential mechanism Erianin on recovery brain cells following a traumatic injury (TBI). TBI rat models were prepared treated with injection via tail vein. assessment included evaluating rats' levels oxidative stress, inflammation, neuronal damage, mitochondrial regeneration, transformation pro-inflammatory microglial cells, activation status ERK signal pathway, functionality their learning memory. After...
Macroautophagy/autophagy is a catabolic process crucial for degrading cytosolic components and damaged organelles to maintain cellular homeostasis, enabling cells survive in extreme extracellular environments. ENAH/MENA, member of the Ena/VASP protein family, functions as highly efficient actin elongation factor. In this study, our objective was explore role ENAH autophagy process. Initially, we demonstrated that depleting cancer inhibits autophagosome formation. Subsequently, observed...