A5020124819- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Meningioma and schwannoma management
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Hepatitis C virus research
- Autophagy in Disease and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Biochemical effects in animals
- Epigenetics and DNA Methylation
- Cerebrospinal fluid and hydrocephalus
Fudan University
2015-2025
Huashan Hospital
2015-2025
Siemens (China)
2024
Beijing Sanbo Brain Hospital
2020
Capital Medical University
2020
Shanghai Medical College of Fudan University
2014-2019
Developing effective internal wound dressing materials is important for postoperative tissue regeneration while remains a challenge due to the poor biological environment-adaptability of conventional materials. Here, we report an example injectable self-healing hydrogel based on gastric environment-adaptive supramolecular assembly, and have explored its application perforation healing. By leveraging environment-modulated interactions, self-assembled network orchestrated with sensitive...
Rationale: Metastasis, the development of secondary malignant growth at a distance from primary tumor, is main cause cancer-associated death. However, little known about how metastatic cancer cells adapt to and colonize in new organ environment. Here we sought investigate functional mechanism cholesterol metabolic aberration colorectal carcinoma (CRC) liver metastasis. Methods: The expression metabolism-related genes tumors (PT) paired metastases (LM) were examined by RT-PCR. role...
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) accurately recapitulates the cellular molecular pathology of human brain tumors. Patient-derived explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling wide range tumors central...
H3 K27M-mutant gliomas present heterogeneously in terms of pathology, imaging, and prognosis. This study aimed to summarize the imaging characteristics adult gliomas.
Background Patients with breast cancer brain metastases (BCBM) experience a rapid decline in their quality of life. Recently, tertiary lymphoid structures (TLSs), analogs secondary organs, have attracted extensive attention. However, the potential clinical implications TLSs BCBMs are poorly understood. In this study, we evaluated density and composition described prognostic value. Methods Clinicopathological data were collected from 98 patients (2015–2021). evaluated, TLS scoring system was...
Forkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) glioblastoma (GBM) remained discrepant. In this study, we aimed explore whether subtype TILs correlated with prognosis patients GBM. well CD8+ ones were detected by immunohistochemistry on paraffin-embedded samples from 62 patients. Staining...
Highlights•Sirt5+ subset in wild-type Kras colorectal tumors determines multidrug resistance•Sirt5-mediated demalonylation and inactivation of SDHA lead to succinate accumulation•Succinate binds activates TrxR2 maintain chemotherapy resistance•Succinate inhibits aKG-dependent dioxygenases regulate cetuximab resistanceSummaryA major obstacle for successful management patients with carcinoma (CRC) is resistance anti-cancer cytotoxic treatments. Here, we identified a mechanism CRCs based on the...
OBJECTIVE Treatment with a BRAF mutation inhibitor might shrink otherwise refractory craniopharyngiomas and is promising preoperative treatment to facilitate tumor resection. The aim of this study was investigate the noninvasive diagnosis BRAF-mutated based on MRI characteristics. METHODS Fifty-two patients pathologically diagnosed craniopharyngioma were included in study. Polymerase chain reaction performed tissue specimens detect CTNNB1 mutations. manifestations-including location, size,...
The central nervous system (CNS) maintains homeostasis with its surrounding environment by restricting the ingress of large hydrophilic molecules, immune cells, pathogens, and other external harmful substances to brain. This function relies heavily on blood-cerebrospinal fluid (B-CSF) blood-brain barrier (BBB). Although considerable research has examined structure BBB, B-CSF received little attention. Therapies for disorders associated have potential benefit from targeting enhance medication...
Gliomas exhibit high heterogeneity and poor prognosis. Despite substantial progress has been made at the genomic transcriptomic levels, comprehensive proteomic characterization its implications remain largely unexplored. In this study, we perform profiling of gliomas using 343 formalin-fixed paraffin-embedded tumor samples 53 normal-appearing brain from 188 patients, integrating these data with panel information clinical outcomes. The analysis uncovers two distinct subgroups: Subgroup 1,...
Objective To determine if the density of FOXP3+ lymphocytes in primary tumors and lymph nodes pancreatic cancer correlates with presence node metastases. Methods lymphocyte tissue draining was measured using immunohistochemistry. We analyzed clinical pathological aspects associated accumulation cancer. also correlation nodal status distance from tumor. Results significantly higher than paratumoral tissue. The local tumor correlated histological grade overall status. Furthermore, positive...
The abnormal phosphatase and tensin homolog expression activated phosphoinositide-3 kinase/Protein kinase B (AKT)/mammalian target of rapamycin signaling pathway are involved in the progression esophageal squamous cell carcinoma. By assessing pattern key components kinase/AKT/mammalian by immunohistochemistry tumor nontumor mucosa from patients with carcinomas, we aimed to carefully explore relationship between various protein expressions clinicopathological factors, as well patient outcome....
Congenital hepatic fibrosis is a hereditary fibropolycystic disease caused by ductal plate malformation. It characterized portal hypertension, but the manifestations, management, and outcome vary in children adults. To raise awareness of medical staff, we have comprehensively compared clinical features congenital between We retrospectively enrolled all patients diagnosed with at Huashan Hospital from August 2015 to 2017 analyzed their familial, clinical, laboratory, imaging, treatment,...
"Primary papillary epithelial tumor of the sella (PPETS)" is a recently described rare entity central nervous system (CNS) with stereotypic location in sella. Comprehensive molecular investigations and epigenetic profiles PPETS have not been performed to date.We report comprehensive clinical, histopathologic, assessment 5 cases comparison cohort composed 7 choroid plexus papilloma (CPP), neurocytoma (CN), 15 posterior pituitary (PPT) including 4 pituicytoma, 6 granular cell tumors sellar...
Abstract Gliomas are highly heterogenous diseases with poor prognosis. Precise survival prediction could benefit further clinical decision‐making, trial incursion, and health economics. Recent research has emphasized the prognostic value of magnetic resonance imaging, pathological specimens, circulating biomarkers. However, integrative potential efficacy these modalities require to be validated. After incorporating 218 patients The Cancer Genome Atlas glioma datasets 54 Huashan cohort...