A5101827184- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Uterine Myomas and Treatments
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Immune cells in cancer
- Endometriosis Research and Treatment
- Cervical Cancer and HPV Research
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Sepsis Diagnosis and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Traditional Chinese Medicine Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Virus-based gene therapy research
- Drug Transport and Resistance Mechanisms
- Neurosurgical Procedures and Complications
Huashan Hospital
2016-2025
Fudan University
2016-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2025
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Nantong University
2024
Affiliated Hospital of Nantong University
2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Shanghai Clinical Research Center
2024
Surgical resection is a mainstay in the treatment of malignant brain tumors. Surgeons, however, face great challenges distinguishing tumor margins due to their infiltrated nature. Here, pair gold nanoprobes that enter by crossing blood-brain barrier developed. The acidic environment triggers assembly with concomitant activation both magnetic resonance (MR) and surface-enhanced Raman spectroscopy (SERRS) signals. While bulky aggregates continuously trap into interstitium, intact normal tissue...
Abstract Surgeons face challenges in intraoperatively defining margin of brain tumors due to its infiltrative nature. Extracellular acidosis caused by metabolic reprogramming cancer cells is a reliable marker for tumor regions. Although the acidic margin‐guided surgery shows promise improving surgical prognosis, clinical transition delayed having exogenous probes approved drug supervision authority. Here, an intelligent surface‐enhanced Raman scattering (SERS) navigation system delineating...
Glioma is the most frequent form of malignant brain tumors. Surgical debulking a major strategy for glioma treatment. However, there great challenge neurosurgeons to intraoperatively identify true margins because its infiltrative nature. Tumor residues or microscopic satellite foci left in resection bed are main reasons leading early recurrence as well poor prognosis. In this study, surface-enhanced resonance Raman scattering (SERRS) probe was developed guide resection. probe, molecular...
Considering the narrow window of surgery, early diagnosis liver cancer is still a fundamental issue to explore. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICCA) are considered as two different types because their distinct pathogenesis, pathological features, prognosis, responses adjuvant therapies. Qualitative analysis image not enough make discrimination cancer, especially early-stage HCC or ICCA.This retrospective study developed radiomic-based model in training...
To establish and validate a radiomics-based model for staging liver fibrosis at contrast-enhanced CT images.This retrospective study developed two models (R-score: radiomics signature; R-fibrosis: integrate radiomic serum variables) in training cohort of 332 patients (median age, 59 years; interquartile range, 51-67 256 men) with biopsy-proven who underwent between January 2017 December 2020. Radiomic features were extracted from non-contrast, arterial portal phase images selected using the...
Circular RNAs (circRNAs) represent a novel class of non-coding that play significant roles in tumorigenesis and tumor progression. High-throughput sequencing gastric cancer (GC) tissues has identified circRNA BIRC6 (circBIRC6) as potential derived from the gene, exhibiting upregulation GC tissues. The expression circBIRC6 is notably elevated patients. Functionally, it acts molecular sponge for miR-488, consequently upregulating GRIN2D promoting proliferation, migration, invasion. Moreover,...
Forkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) glioblastoma (GBM) remained discrepant. In this study, we aimed explore whether subtype TILs correlated with prognosis patients GBM. well CD8+ ones were detected by immunohistochemistry on paraffin-embedded samples from 62 patients. Staining...
Blood-brain barrier (BBB) disruption is frequently observed in the glioma region.However, tumor uptake of drugs still too low to meet threshold therapeutic purpose.Method: A vasculature-targeted nanoagonist was developed.Glioma targeting specificity evaluated by vivo optical imaging.BBB permeability at margin quantitatively measured dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).Single-photon emission computed tomography imaging/computed (SPECT/CT) determined radiolabeled...
Cancer-testis genes are involved in the occurrence and development of cancer, but role cancer-testis-associated lncRNAs (CT-lncRNAs) hepatocellular carcinoma (HCC) remains to be explored. Here, we discovered a novel CT-lncRNA, LINC01977, based on Genotype-Tissue Expression (GTEx) The Cancer Genome Atlas (TCGA) databases. LINC01977 was exclusively expressed testes highly HCC. High levels correlated with poorer overall survival (OS) individuals Functional assays showed that promoted HCC growth...
Introduction Sepsis is intricately linked to intestinal damage and barrier dysfunction. At present times, there a growing interest in metabolite-based therapy for multiple diseases. Methods Serum samples from septic patients healthy individuals were collected their metabonomics profiling assessed using Ultra-Performance Liquid Chromatography-Time of Flight Mass Spectrometry (UPLC-TOFMS). The eXtreme Gradient Boosting algorithms (XGBOOST) method was used screen essential metabolites...
The therapeutic efficacy of oncolytic adenoviruses (OAs) relies on efficient viral transduction and replication. However, the limited expression coxsackie-adenovirus receptors in many tumors, along with intracellular antiviral signaling, poses significant obstacles to OA infection oncolysis. Here, we present sonosensitizer-armed OAs (saOAs) that potentiate antitumor virotherapy through sonodynamic therapy-augmented virus saOAs could not only efficiently infect tumor cells via transferrin...
A novel pH ratiometrically responsive surface-enhanced resonance Raman scattering (SERRS) probe was developed for tumor acidic margin delineation and image-guided surgery.
Accurate delineation of glioma infiltrative margins remains a challenge due to the low density cancer cells in these regions. Here, hierarchical imaging strategy define by locating immunosuppressive tumor-associated macrophages (TAMs) is proposed. A pH ratiometric fluorescent probe CP2-M that targets TAMs binding mannose receptor (CD206) developed, and it subsequently senses acidic phagosomal lumen, resulting remarkable fluorescence enhancement. With assistance CP2-M, xenografts mouse models...
Surgery is a mainstay to treat malignant brain tumors. However, due the infiltrative nature of these tumors, it great challenge for surgeons accurately identify and excise all tumor foci. EGFRvIII, variant epidermal growth factor receptor (EGFR), found in 20% glioblastoma cases, which with highest malignancy. In this study, we developed an EGFRvIII-targeted nanoprobe guide surgery by pre-operatively defining boundary via magnetic resonance imaging (MRI) intra-operatively guiding resection...
The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1WT) group which exhibits a poor prognosis with median survival less than 15 months. This study demonstrated numerous immunosuppressive genes as well β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1WT glioma using Chinese Glioma Genome Atlas (CGGA) database. increase microglia an phenotype and overexpression protein further verified GBM GL261...
Abstract Purpose: PET imaging targeting the purinergic receptor subtype 7 (P2X7R) is of high interest for assessing glioma microenvironment. No reports were published regarding P2X7R in gliomas. Therefore, we compared uptake characteristics 18F-GSK1482160, a novel ligand, to conventional 11C-MET and contrast-enhanced MRI patients with Experimental Design: Thirteen (8 grade II, 5 III/IV) at initial diagnosis consecutively included underwent 18F-GSK1482160 PET, MRI. The semi-quantitative...
To evaluate the ability of median nerve stimulation (MNS)-induced high gamma band (HGB) activity in mapping hand motor cortex at different states consciousness. Five patients undergoing awake craniotomy were recruited. MNS-induced electrocorticographic signals recorded from to anesthetic states, with loss consciousness (LOC) session divided into three stages (LOC1, LOC2, and LOC3) based on conscious level. HGB analyzed localize cortex. Linear models applied analyze dynamics during LOC. The...
Magnetic Resonance Elastography (MRE) can characterize biomechanical properties of soft tissue for disease diagnosis and treatment planning. However, complicated wavefields acquired from MRE coupled with noise pose challenges accurate displacement extraction modulus estimation. Using optimization-based Traveling Wave Expansion-based Neural Network (TWENN) estimation, we propose a new pipeline processing images. An objective function Dual Data Consistency (Dual-DC) has been used to ensure...
Abstract Sepsis is known to cause damage the intestinal mucosa, leading bacterial translocation, and exacerbation of both local remote organ impairments. In present study, fecal samples were collected from septic healthy individuals. Analysis through 16s rRNA sequencing microbiota revealed that sepsis disrupts balance gut microbial community. Recent research has highlighted association lipid metabolism with disease. By analyzing metabolome, four metabolites showed significant differences...
Even though opening endothelial tight junctions is an efficient way to up-regulate brain drug delivery, the extravasation of blood-borne components from compromised can result in adverse consequences such as edema and neuronal injuries. In this work, we developed a nanoagonist that temporarily opened by signaling adenosine 2A receptor, type G protein-coupled receptor expressed on capillary cells. Magnetic resonance imaging demonstrated remarkable blood-brain barrier permeability enhancements...
Colonization of the intestinal tract by Candida albicans (C. albicans) can lead to invasive candidiasis. Therefore, a functional epithelial barrier is critical for protecting against C. infections. We collected fecal samples from patients with bloodstream infection and healthy people. Through flora 16sRNA sequencing metabolomic analysis, we found that resulted in significant decrease expression metabolite kynurenic acid (KynA). used repeated mouse model, established following intake 3%...