A5103237103- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Cancer-related gene regulation
- Black Holes and Theoretical Physics
- Bone Tissue Engineering Materials
- Membrane Separation Technologies
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Extraction and Separation Processes
- Cosmology and Gravitation Theories
- RNA modifications and cancer
- Membrane-based Ion Separation Techniques
- Graphene and Nanomaterials Applications
- Wnt/β-catenin signaling in development and cancer
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Intracranial Aneurysms: Treatment and Complications
- Hormonal Regulation and Hypertension
- RNA Research and Splicing
Weifang People's Hospital
2025
Shenzhen University
2016-2024
Anhui University
2018-2024
Zhejiang University
2024
Nanjing University of Chinese Medicine
2021-2024
Women's Hospital, School of Medicine, Zhejiang University
2022-2024
XinHua Hospital
2018-2023
Shanghai Jiao Tong University
2018-2023
Jinan Stomatological Hospital
2023
Institute of Oceanographic Instrumentation
2021-2023
Long non-coding RNAs (lncRNAs) play an important role in gene regulation and are involving diverse cellular processes. However, their roles reprogramming of expression profiles during lineage commitment maturation mesenchymal stem cells (MSCs) remain poorly understood. In the current study, we characterize a lncRNA, HoxA-AS3, differentiation MSCs. We showed that HoxA-AS3 is increased upon adipogenic induction MSCs, while remains unaltered osteogenic induction. Silencing MSCs resulted...
Homeobox (HOX) genes encode a family of transcription factors, which play crucial roles in numerous processes, and their dysregulation is involved the carcinogenesis many human cancers. In present study, we investigated HOXC8 non-small cell lung cancer (NSCLC). We showed that was upregulated clinical NSCLC specimens compared to normal tissues, high expression correlated with tumor node metastasis (TNM) stage, status, lymph nodal status poor relapse-free survival for patients. Functionally,...
Distal metastases of tumors result from the interaction between "seeds" (circulating tumor cells, CTCs) and "soil" (premetastatic niche, PMN). Various strategies focus on CTC inhibition, but only a few inhibit PMN formation. The main predisposition formation in melanoma lies pulmonary recruitment granulocytic myeloid-derived suppressor cells (G-MDSCs, CD11b+Ly6G+ cells) induced by tumors, which increase vascular permeability secreting matrix metalloproteinase-9 (MMP-9) immunosuppression...
To establish and validate a radiomics-based model for staging liver fibrosis at contrast-enhanced CT images.This retrospective study developed two models (R-score: radiomics signature; R-fibrosis: integrate radiomic serum variables) in training cohort of 332 patients (median age, 59 years; interquartile range, 51-67 256 men) with biopsy-proven who underwent between January 2017 December 2020. Radiomic features were extracted from non-contrast, arterial portal phase images selected using the...
Abstract Immunotherapy is a required adjuvant method in lung cancer therapy clinically. The single immune failed to show the expected clinical therapeutic efficacy due its rapid drug metabolism and inability accumulate tumor site efficiently. Immunogenic cell death (ICD) new anti‐tumor strategy combined with adjuvants. It can provide tumor‐associated antigens, activate dendritic cells, attract lymphoid T cells into microenvironment. Here doxorubicin‐induced membrane‐coated iron...
Sweat is a noninvasive metabolite that can provide clinically meaningful information about physical conditions without harming the body. Glucose, vital component in sweat, closely related to blood glucose levels, and changes its concentration reflect health status of diabetics. We introduce self-adhesive, wearable microfluidic chip with erasable liquid metal plasmonic hotspots for precise detection sweat. The made from modified polydimethylsiloxane (PDMS) enhanced stickiness, enabling...
We consider the gravity dual of strongly coupled system at a Lifshitz-fixed point and finite temperature, which was constructed in recent work arXiv:0909.0263. construct an Abelian Higgs model that background calculate condensation conductivity using holographic techniques. find happens DC blows up when temperature turns below critical value.
High-efficiency treatment for tumor is not easy to achieve owing the existence of metastasis, which remains arch-criminal most deaths. Conventional chemotherapy exhibits insufficient inhibitory efficiency on metastasis and more powerful strategies conquer metastatic tumors are urgently needed. In this study, a rational chemoimmunotherapy strategy was adopted treat highly aggressive melanoma based newly developed multifunctional nanoplatform. Firstly, immunoadjuvant cytosine-phosphate-guanine...
Tribbles homolog 2 (TRIB2) is specifically regulated by Wnt signaling in liver cancer cells but not colon cells. However, whether and how TRIB2 regulates remains unclear. Here, we report that negatively activity through a reduction protein stability of TCF4 β‐Catenin. Mechanistically, associated‐ubiquitin E3 ligases beta‐transducin repeat‐containing ubiquitin ligase (β‐TrCP), COP1 Smad ubiquitination regulatory factor 1 (Smurf1) reduced TCF4/β‐Catenin expression, these effects could be...
Abstract Triple‐negative breast cancer (TNBC) is the most aggressive subtype which accounts for 15%‐20% of all cases. The management TNBC has remained a challenge due to its lack targeted therapy. Previously, we reported that homeobox C8 (HOXC8) was involved in metastasis and migration cells. By chromatin immunoprecipitation luciferase assays, found HOXC8 functioned as transcription factor activate matrix Gla protein (MGP) gene, leading an increase proliferation, anchorage‐independent...
PurposeTo examine the turnover intention of Chinese pediatric nurses, its influential socio-demographic factors, and association with calling job satisfaction.Design methodsWe randomly surveyed 10% nurses from 50% children's tertiary hospitals nationwide in China. Data were collected on nurses' associated factors such as age, income, skill level, working years, satisfaction, 2017.ResultsIn total, 547 surveyed, response rate was 98.6%. More than a third had to quit their current jobs....
Alginate oligosaccharides produced by enzymatic degradation show versatile physiological functions and biological activities. In this study, a new alginate lyase encoding gene alyS02 from Flavobacterium sp. S02 was recombinantly expressed at high level in Yarrowia lipolytica, with the highest extracellular activity supernatant reaching 36.8 ± 2.1 U/mL. AlyS02 classified polysaccharide (PL) family 7. The optimal reaction temperature pH of enzyme were 30 °C 7.6, respectively, indicating that...
The effect of long intergenic noncoding RNA 01315 (LINC01315) on colorectal cancer has widely been proved. Nevertheless, how LINC01315 functions in the stemness and whether exists stem-like cell-derived exosomes remain dim, which are thus investigated this research. CD133+/CD44+ stem cells were sorted verified through flow cytometry. Exosomes derived from collected. viability, proliferation, migration CD133+/CD44+, CD133-/CD44-, after transfection or co-culture with detected by MTT, colony...
Heparin-binding protein (HBP) is a novel biomarker for inflammatory diseases. This study aimed to investigate the role of serum HBP in community-acquired pneumonia (CAP) children and association with severity prognosis.A total 125 CAP admitted hospital were enrolled this retrospective study. We analyzed differences clinical characteristics examination findings between patients different levels HBP. The severe or complicated was defined as having radiographic and/or systemic manifestations....