A5045413265- Cardiac Ischemia and Reperfusion
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Diet, Metabolism, and Disease
- Phagocytosis and Immune Regulation
- Inflammasome and immune disorders
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Advanced Glycation End Products research
- Diet and metabolism studies
- Plant Toxicity and Pharmacological Properties
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer Cells and Metastasis
- Cardiovascular Function and Risk Factors
- Nuclear Receptors and Signaling
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
First Affiliated Hospital of Sichuan Medical University
2016-2025
Affiliated Hospital of Southwest Medical University
2017-2025
Shanghai Clinical Research Center
2025
Sichuan University
2002-2025
Tianjin University of Traditional Chinese Medicine
2024-2025
Guizhou Provincial People's Hospital
2024
Guiyang Medical University
2024
First People's Hospital of Foshan
2024
Southwest Medical University
2016-2024
Xi'an Medical University
2023
Microplastics (MPs) considered as a new persistent environmental pollutant could enter into the circulatory system and result in decrease of sperm quantity quality mice. However, effects Polystyrene MPs (PS MPs) on ovary its mechanism rats remained unclear. In this present study, thirty-two healthy female Wistar were exposed to different concentrations 0.5 µm PS dispersed deionized water for 90 days. Using hematoxylin-eosin (HE) staining, number growing follicles was decreased compared...
Recurrence and metastasis are the leading causes of tumour-related death in patients with oesophageal squamous cell carcinoma (ESCC). Tumour-infiltrating natural killer cells (NK cells) display powerful cytotoxicity to tumour play a pivotal role therapy. However, phenotype functional regulation NK (ESCC) remains largely unknown. Single suspensions from blood tissue samples were isolated by physical dissociation filtering through 70 μm strainer. Flow cytometry was applied profile activity...
Diabetic nephropathy (DN) is a chronic low-grade inflammatory disease. Oxidative stress and nuclear factor kappa B (NF- κ B) signaling play an important role in the pathogenesis of DN. Short-chain fatty acids (SCFAs) produced from carbohydrate fermentation gastrointestinal tract exert positive regulatory effects on inflammation kidney injuries. However, it unclear whether SCFAs can prevent ameliorate In present study, we evaluated mechanism three main (acetate, propionate, butyrate) high-fat...
While inflammation is considered a central component in the development diabetic nephropathy, mechanism remains unclear. The NLRP3 inflammasome acts as both sensor and regulator of inflammatory response. responds to exogenous endogenous danger signals, resulting cleavage procaspase-1 activation cytokines IL-1β, IL-18, IL-33, ultimately triggering an cascade reaction. This study observed expression signaling stimulated by high glucose, lipopolysaccharide, reactive oxygen species (ROS)...
Abstract Chemoimmunotherapy‐induced antitumor immune response is highly dependent on tumor autophagy. When cells are treated with chemoimmunotherapy, timely overactivated autophagy can not only lead more to death, but also participate in the endogenous antigen presentation and stimulators secretion of dying cells, thus plays a vital role. However, accurately during chemoimmunotherapy great difficulty. Here, an on‐demand cascade amplification nanoparticle (ASN) reported boost...
Distal metastases of tumors result from the interaction between "seeds" (circulating tumor cells, CTCs) and "soil" (premetastatic niche, PMN). Various strategies focus on CTC inhibition, but only a few inhibit PMN formation. The main predisposition formation in melanoma lies pulmonary recruitment granulocytic myeloid-derived suppressor cells (G-MDSCs, CD11b+Ly6G+ cells) induced by tumors, which increase vascular permeability secreting matrix metalloproteinase-9 (MMP-9) immunosuppression...
Glioma, one of the most common aggressive malignancies, has highest mortality in present world. Delivery nanocarriers from systemic circulation to glioma sites would encounter multiple physiological and biological barriers, such as blood–brain barrier (BBB) poor penetration into tumor. To circumvent these hurdles, paclitaxel-loaded liposomes were developed by conjugating with a TR peptide (PTX-TR-Lip), integrin αvβ3-specific vector pH-responsible cell-penetrating property, for transporting...
Arketamine, the (R)-enantiomer of ketamine, exhibits antidepressant-like effects in mice, though precise molecular mechanisms remain elusive. It has been shown to reduce splenomegaly and depression-like behaviors chronic social defeat stress (CSDS) model depression. This study investigated whether spleen contributes arketamine CSDS model. We found that splenectomy significantly inhibited arketamine's CSDS-susceptible mice. RNA-sequencing analysis identified oxidative phosphorylation (OXPHOS)...
Abstract Metastasis remains the main driver of mortality in patients suffering from cancer because refractoriness resulting multi‐phase metastatic cascade. Herein, a multifunctional self‐delivering PBA‐LMWH‐TOS nanoparticle (PLT NP) is established that acts as both nanocarrier and anti‐metastatic agent with effects on most hematogenous metastases cancers. The hydrophilic segment (low molecular weight heparin, LMWH) inhibits interactions between tumor cells platelets. hydrophobic ( d...
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin (DOX) and Toll-like receptor 7 agonist imiquimod (IMQ) in low molecular weight heparin (LMWH)-d-
Mitochondrial autophagy is involved in myocardial protection of sevoflurane postconditioning (SPostC) and diabetic state this protective effect weakened due to impaired HIF-1 signaling pathway. Previous studies have proved that deferoxamine (DFO) could activate HIF-1α restore the cardioprotective sevoflurane, while specific mechanism unclear. This study aims investigate whether /BNIP3-mediated mitochondrial restoration cardioprotection state. Ischemia/reperfusion (I/R)model was established...
Alcoholic fatty liver disease (AFLD) is characterized by hepatic steatosis and carries an elevated risk of cirrhosis hepatocellular carcinoma. However, the mechanism AFLD has not been elucidated thoroughly, there are still no efficient therapies in clinic. Notably, butyrate, one kind short-chain acids produced gut microbiota, shown to improve methionine-choline-deficient diet-induced non-alcoholic steatohepatitis. And our previous study found that butyrate ameliorated endotoxemia db/db mice....
Background . Inflammation and fibrosis are the important pathophysiologic processes in diabetic nephropathy (DN). Maresin 1 is a potential anti-inflammatory lipid mediator, which has displayed powerful proresolving activities. Aim We determine whether maresin protective effect on mouse glomerular mesangial cells (GMCs) induced by high glucose. Methods cultured GMCs stimulated glucose categorized as follows: normal group (5.6 mmol/L), (30 mannitol group, intervention (1, 10, 100 nmol/L),...