A5012422990- Advanced Glycation End Products research
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Chronic Kidney Disease and Diabetes
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Phytoestrogen effects and research
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Lipid metabolism and disorders
- Hormonal Regulation and Hypertension
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Barrier Structure and Function Studies
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
Macau University of Science and Technology
2016-2025
Quality Research
2021-2025
University of Macau
2013-2025
Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine
2020-2023
National Astronomical Observatories
2023
Chinese Academy of Sciences
2023
Hefei University of Technology
2017
Affiliated Hospital of Southwest Medical University
2017
Nanjing Medical University
2008-2011
Diabetic nephropathy (DN) is a chronic low-grade inflammatory disease. Oxidative stress and nuclear factor kappa B (NF- κ B) signaling play an important role in the pathogenesis of DN. Short-chain fatty acids (SCFAs) produced from carbohydrate fermentation gastrointestinal tract exert positive regulatory effects on inflammation kidney injuries. However, it unclear whether SCFAs can prevent ameliorate In present study, we evaluated mechanism three main (acetate, propionate, butyrate) high-fat...
Recently, an connection between Short-chain fatty acids (SCFAs) produced by intestinal microbiota and kidney has been revealed. The aim of this study was to explore whether SCFAs or their specific G protein-coupled receptors 43 (GPR43) agonist inhibit oxidative stress inflammatory response in glomerular mesangial cells (GMCs) induced high glucose lipopolysaccharide (LPS). Our research showed that treatment with SCFAs, especially acetate butyrate, GPR43 significantly inhibited GMCs...
Endotoxemia has been recognized to be closely accompanied with type 2 diabetes mellitus (T2DM) and is responsible for many diabetic complications. Recent study suggests the potential role of butyrate, a short-chain fatty acid (SCFA) from microbiota metabolite, on T2DM. Gut-leak key event in diabetic-endotoxemia. To investigate if butyrate could ameliorate diabetic-endotoxemia, both vivo vitro experiments were carried out present study. The effect supplementation blood HbA1c inflammatory...
Liver plays a central role in modulating blood glucose level. Our most recent findings suggested that supplementation with microbiota metabolite sodium butyrate (NaB) could ameliorate progression of type 2 diabetes mellitus (T2DM) and decrease HbA1c db/db mice. To further investigate the homeostasis glycogen metabolism, we carried out present study. In mice, found significant hypertrophy steatosis hepatic lobules accompanied by reduced storage, expression GPR43 was significantly decreased...
Diabetic wound (DW) is characterized by elevated pro-inflammatory cytokines and cellular dysfunction consistent with reactive oxygen species (ROS) levels. Recent advances in immunology have dissected molecular pathways involved the innate immune system where cytoplasmic DNA can trigger STING-dependent inflammatory responses play an important role metabolic-related diseases. We investigated whether STING regulates inflammation DW healing. found that M1 macrophages were increased tissues from...
Background: Ischemic stroke (IS) causes tragic death and disability worldwide. However, effective therapeutic interventions are finite. After IS, blood–brain barrier (BBB) integrity is disrupted, resulting in deteriorating neurological function. As a novel therapeutic, extracellular vesicles (EVs) have shown ideal restorative effects on BBB post-stroke; however, the definite mechanisms remain ambiguous. In present study, we investigated curative of EVs derived from bone marrow mesenchymal...
Astragaloside II (AS II), a novel saponin purified from Astragalus membranes, has been reported to modulate the immune response, repair tissue injury, and prevent inflammatory response. However, protective effects of AS on podocyte injury in diabetic nephropathy (DN) have not investigated yet. In this study, we aimed investigate beneficial mitochondrial dysfunction DN. Diabetes was induced with streptozotocin (STZ) by intraperitoneal injection at 55 mg/kg rats. Diabetic rats were randomly...
Abstract Background Brain impairment is one of a major complication diabetes. Dietary flavonoids have been recommended to prevent brain damage. Astragalus membranaceus herbal medicine commonly used relieve the complications Flavonoids ingredients membranaceus, but its function and mechanism on diabetic encepholopathy still unknown. Methods Type 2 diabetes mellitus (T2DM) model was induced by high fat diet STZ in C57BL/6J mice, BEnd.3 HT22 cell lines were applied vitro study. Quality...
Prevention of diabetic heart myocardial ischemia-reperfusion (IR) injury (MIRI) is challenging. Propofol attenuates MIRI through its reactive oxygen species scavenging property at high doses, while use doses causes hemodynamic instability. Salvianolic acid A (SAA) a potent antioxidant that confers protection against MIRI. Both propofol and SAA affect metabolic profiles regulating Adenosine 5'-monophosphate-activated protein kinase (AMPK). The aim this study was to investigate the protective...