A5101415450- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Inflammatory Bowel Disease
- Cancer-related Molecular Pathways
- Hormonal and reproductive studies
- Hematopoietic Stem Cell Transplantation
- Medical Research and Treatments
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Renal and Vascular Pathologies
- Sperm and Testicular Function
- Extracellular vesicles in disease
- Polyomavirus and related diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Education and Military Integration
- Regional Development and Environment
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin D Research Studies
- Gestational Trophoblastic Disease Studies
First Affiliated Hospital of Soochow University
2006-2024
Guangdong Medical College
2019-2024
Soochow University
2006-2024
Second Military Medical University
2014-2023
Changhai Hospital
2014-2023
Chongqing Medical University
2011-2023
Children's Hospital of Chongqing Medical University
2011-2023
University of Hong Kong
2015
Rutgers, The State University of New Jersey
2007-2013
Dana-Farber Cancer Institute
2013
Autophagy is a catabolic process involving self-digestion of cellular organelles during starvation as means cell survival; however, if it proceeds to completion, autophagy can lead death. also haploinsufficient tumor suppressor mechanism for mammary tumorigenesis, the essential regulator beclin1 monoallelically deleted in breast carcinomas. However, by which suppresses cancer remains elusive. Here we show that allelic loss and defective sensitized epithelial cells metabolic stress...
Abstract Hereditary breast cancers stem from germline mutations in susceptibility genes such as BRCA1, BRCA2, and PALB2, whose products function the DNA damage response redox regulation. Autophagy is an intracellular waste disposal stress mitigation mechanism important for alleviating oxidative activation; it can either suppress or promote cancer, but its role cancer unknown. Here, we show that similar to Brca1 Brca2, ablation of Palb2 mouse mammary gland resulted tumor development with long...
Abstract Background Inflammatory bowel disease (IBD) and psoriasis (Ps) are common immune‐mediated diseases that exhibit clinical comorbidity, possibly due to a genetic structure. However, the exact mechanism remains unknown. Methods The study population consisted of IBD Ps genome‐wide association (GWAS) data. Genetic correlations were first evaluated. Then, overall evaluation employed LD score regression (LDSC), while local assessment utilized heritability estimation from summary statistics...
Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide. The poor prognosis colorectal patients due to development chemoresistance metastasis. Recently osteopontin (OPN) has been associated with stem-like properties in cancer. This study further examined clinicopathological significance OPN CRC its effect on transcription stem cell markers. We level 84 correlated expression their parameters. associations overexpression markers response chemotherapy DLD1-OPN...
Although the long non-coding RNA THOR has been reported to promote cancer stem cell expansion in liver and gastric cancer, its effects on osteosarcoma (OS) cells remain unclear. Here, we investigated roles of stemness migration OS cells. We report that level is remarkably upregulated spheroids compared adherent overexpression increased spheroid formation ability aldehyde dehydrogenase 1 (ALDH1) activity cells, opposite effect was observed with knockdown. Additionally, formed by exhibited a...
Prevention of diabetic heart myocardial ischemia-reperfusion (IR) injury (MIRI) is challenging. Propofol attenuates MIRI through its reactive oxygen species scavenging property at high doses, while use doses causes hemodynamic instability. Salvianolic acid A (SAA) a potent antioxidant that confers protection against MIRI. Both propofol and SAA affect metabolic profiles regulating Adenosine 5'-monophosphate-activated protein kinase (AMPK). The aim this study was to investigate the protective...
Background The comorbidity rate of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is high; nevertheless, the reasons behind this high remain unclear. Their similar genetic makeup probably contributes to comorbidity. Methods Based on data obtained from genome-wide association study IBD RA, we first assessed an overall by performing linkage disequilibrium score regression (LDSC) analysis. Further, a local correlation analysis was performed estimating heritability in summary...
Skin cutaneous melanoma(SKCM) is the most severe, and complex disease of all skin cancers. The molecular mechanisms this cancer progression are not well understood.GEPIA online database was used to validate differentially expressed genes from two GEO datasets. prognostic value calculated by Kaplan-Meier method. RT-qPCR verified expression TUBB4A in SKCM cell line, immunohistochemistry normal tissues were gained Human Protein Atlas. Seven target prediction databases predicted potential...
Abstract We aim to assess the safety and efficacy of proxalutamide, a novel androgen receptor antagonist, for men with metastatic castration‐resistant prostate cancer (mCRPC) in multicenter, randomized, open‐label, phase 2 trial. In our study, enrolled mCRPC patients were randomized 100, 200 300 mg dose groups at 1:1:1. The primary endpoint was prostate‐specific antigen (PSA) response rate. secondary endpoints included objective rate (ORR), disease control (DCR) time PSA radiographic...
Abstract Background Recently, CD40 polymorphism was found to be associated with acute coronary syndromes. However, few study involved in the relationship between and risk of vulnerable plaque rupture so far. Materials Methods A total 699 patients who have received angiography were divided into 3 groups according morphological division plaques: complex lesions (343 cases), smooth (131 control group (225 cases).The gene measured by polymerase chain reaction restriction fragment length...
The objective of this study was to investigate the effect miR-148a on polarization and recruitment tumor-associated macrophages (TAMs). In human monocyte THP-1 cells, M1 or M2 differentiation induced by phorbol 12-myristate 13-acetate (PMA) with specific induction supplements identified using flow cytometry ELISA. To alter cellular expression level, cells were transfected mimics inhibitors. A dual-luciferase assay used determine whether could directly regulate signal regulatory protein α...
To explore the clinical characteristics, molecular treatment and prognosis of pediatric Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) with a therapeutic target.
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Chen G, Yan J. Integrated bioinformatics-based identification of potential diagnostic biomarkers associated with atopic dermatitis. Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology. 2022. doi:10.5114/ada.2022.114899. APA Chen, G., & Yan, (2022). https://doi.org/10.5114/ada.2022.114899 Chicago Guanghua, Jia Yan. "Integrated dermatitis". Harvard MLA Guanghua et al. dermatitis."...
Experimental rat varicocele was usually developed by the conventional technique but with varied success; and microsurgical model an effective alternative. In this study we further analyzed differential outcome of experimental without microsurgery.One hundred twenty male Sprague-Dawley rats were randomly assigned to two groups. Group A, technique. The left renal vein partially ligated concurrent ligation communicating branches between spermatic common iliac vein. B, all above procedures...