A5055427794- Gold and Silver Nanoparticles Synthesis and Applications
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Analytical chemistry methods development
- Crystallography and molecular interactions
- Mass Spectrometry Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoparticle-Based Drug Delivery
- Energetic Materials and Combustion
- Electrochemical Analysis and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Drug Transport and Resistance Mechanisms
- Analytical Chemistry and Chromatography
- Carbon and Quantum Dots Applications
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Pharmacological Effects of Natural Compounds
- Nanocluster Synthesis and Applications
China Academy of Engineering Physics
2015-2024
Sichuan University
2013-2024
Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Anhui University
2017-2024
Nanjing Tech University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guang’anmen Hospital
2024
Yunnan Normal University
2024
West China Hospital of Sichuan University
2024
Nanjing Drum Tower Hospital
2024
Five novel BTF (benzotrifuroxan) cocrystals, possessing a similar density to RDX (1,3,5-trinitrohexahydro-1,3,5-triazine), have been prepared and reported first. Their single-crystal structures are presented discussed. Interactions between cocrystal formers discussed with shifts in the IR spectra providing additional support for presence of various interactions. Hydrogen-bonding π-stacking interactions found be most prominent. Especially, electron-poor π-systems electron-rich groups other...
A facile fabrication approach of large‐scale flexible films is reported, with one surface side consisting Ag‐nanoparticle (Ag‐NP) decorated polyacrylonitrile (PAN) nanohump (denoted as Ag‐NPs@PAN‐nanohump) arrays. This achieved via molding PAN ordered arrays on and then sputtering much smaller Ag‐NPs onto each the PAN‐nanohumps. Surface‐enhanced Raman scattering (SERS) activity Ag‐NPs@PAN‐nanohump array can be improved by curving film during Ag‐sputtering process to increase density...
Tumor-associated fibroblasts (TAFs), which form a predominant stromal cellular component of the tumor microenvironment, hinder delivery nanomedicine to deep cells and lead poor prognosis tumors. However, depletion TAFs by therapeutic agents results in secretion damage response program (DRP) molecules weaken efficacy treatment. This paper reports multifunctional size-switchable nanoparticle (denoted DGL (dendrigraft poly-l-lysine) (DGL)/GEM@PP/GA) for TAF-targeted regulation penetration....
Chronic diabetic wound healing remains a challenge due to the existence of excessive danger molecules and bacteria in inflammatory microenvironment. There is an urgent need for advanced dressings that target both inflammation infection. Here, bioactive hydrogel without loading any anti-inflammatory ingredients rationally designed achieve "Pull–Push" approach efficient safe bacteria-infected by integrating molecule scavenging (Pull) with antibiotic delivery (Push) The cationic hydrogel,...
The surface-enhanced Raman scattering (SERS) technique is a promising method for the detection of explosives such as 2,4,6-trinitrotoluene (TNT) and 3-nitro-1,2,4-triazol-5-one (NTO) because its high sensitivity to trace substances. However, most SERS processes are often nonautomated well exhibit low efficiency toxic exposure, which poses potential danger operators. Herein, we propose integration with digital microfluidics (SERS-DMF) automated, high-throughput, high-sensitivity explosives....
The ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression HIF-1α and ERK accompanies CCl4-induced liver fibrosis rats. Curcumin verified have antifibrotic effects several kinds models. There no specific evidence illustrating a connection between curcumin HIF-1α/ERK rat induced by CCl4. In this study, was CCl4 treated data demonstrated that able attenuate inhibit proliferation HSC. Moreover, could remarkably elevate...
Tumor metastasis is responsible for most mortality in cancer patients, and remains a challenge clinical treatment. Platelets can be recruited activated by tumor cells, then adhere to circulating cells (CTCs) assist extravasate distant organs. Therefore, nanoparticles specially hitchhiking on platelets are considered have excellent targeting ability primary tumor, CTCs However, the tumor-homing will release transforming growth factor-β (TGF-β), which promotes forms immunosuppressive...
Hypoxia at the tumor site limits therapeutic effects of photodynamic therapy (PDT) in oral squamous cell carcinoma (OSCC), which is an oxygen-consumption process. Inhibiting cellular oxygen consumption and reducing ATP production are expected to enhance PDT. In this study, we designed constructed dandelion-like size-shrinkable nanoparticles for tumor-targeted delivery hypoxia regulator resveratrol (RES) agent chlorine e6 (CE6). Both drugs were co-encapsulated small-sized micelles modified...
Abstract Developing a new strategy to realize on‐demand photoreactions with distinguishable signals is highly desirable. Herein, by simply tuning the molecular state, tuned different dynamic based on series of tridentate cyanostilbene molecules ( TCS1‐5 ) are realized. The results show that in crystalline ordered and densely packing facilitates successive intermolecular photocycloaddition between adjacent causes accumulated stresses within crystals, which further induces variable...
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury and acute failure, while the detection, prognosis prediction, therapy for APAP-induced (AILI) remain improved. Here, it determined that temporal pattern circulating cell-free DNA (cfDNA) strongly associated with damage inflammation parameters in AILI. CfDNA comparable to alanine aminotransferase (ALT) predicting mortality outperformed ALT when combined The depletion cfDNA or neutrophils alleviates damage, addition...
The aim of this article is to introduce the roles and mechanisms JAK2/STAT3 pathway in various cardiovascular diseases, such as myocardial fibrosis, cardiac hypertrophy, atherosclerosis, infarction, ischemiareperfusion. In addition, effects phytochemical ingredients different natural plants, mainly traditional Chinese medicines, on regulation diseases via are discussed. Surprisingly, JAK2 has dual diseases. Future research should focus regulatory plants pave way for their use clinical trials.
A simple and efficient self-approach strategy was used to apply ultrasensitivity self-revive ZnO-Ag hybrid surface-enhanced Raman scattering (SERS) sensors for the highly sensitive selective detection of explosive TNT in both solution vapour conditions. The good ultrasensitive sensing performance is a result abundant hot spots, which were spontaneously formed reversible way by self-approaching flexible nanorods driven capillary force solvent evaporation. Moreover, enhancement effect...
Metastasis is one of the main reasons for high mortality associated with pancreatic ductal adenocarcinoma (PDAC), and autophagy regulates metastatic migration tumor cells, their invasion tissues, formation focal adhesions. Inhibiting may suppress growth metastasis, but abundant extracellular matrix hinders deep penetration therapeutic agents.
In this review, we mainly summarize the emerging luminescent organic molecular frameworks consisting of hydrogen bonded and supramolecular based on tetraphenylethylene building blocks.
Blood and lymph are two main pathways of tumor metastasis; however, hematogenous metastasis lymphatic difficult to inhibit simultaneously. Ferroptosis provides a new breakthrough for inhibition, but how effectively trigger ferroptosis in cells remains major challenge. Metastatic prone blood, while they may be protected from lymph. In this study, nanoplatform DA/RSL3 was constructed the intracellular codelivery polyunsaturated arachidonic acid (AA) GPX4 inhibitor RSL3, which could not only...
A silver nanoparticle-loaded graphene oxide aerogel (GO-Ag ANM) was prepared. The prepared GO-Ag ANM showed great fluorescence quenching and Raman enhancement effects on the fluorescent explosive BPTAP.