A5002977955- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Tuberculosis Research and Epidemiology
- Neurofibromatosis and Schwannoma Cases
- Mycobacterium research and diagnosis
- Sarcoma Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cerebrovascular and Carotid Artery Diseases
- Sodium Intake and Health
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Statistical Methods in Clinical Trials
- Inflammatory Bowel Disease
- Shoulder Injury and Treatment
- Clinical Laboratory Practices and Quality Control
- Liver Disease Diagnosis and Treatment
- Peripheral Artery Disease Management
- Statistical Methods and Inference
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Management of metastatic bone disease
- Adipose Tissue and Metabolism
- Retinal Imaging and Analysis
- Alzheimer's disease research and treatments
- Inflammatory Biomarkers in Disease Prognosis
Beijing Luhe Hospital Affiliated to Capital Medical University
2020-2025
Zhongnan University of Economics and Law
2024
Capital Medical University
2016-2023
Kunming Medical University
2012-2023
Shanghai Pulmonary Hospital
2023
Tongji University
2023
Beijing Chest Hospital
2019-2022
Beijing Children’s Hospital
2020-2022
Zhongnan Hospital of Wuhan University
2017-2021
Wuhan University
2017-2021
Middle East respiratory syndrome coronavirus (MERS-CoV) causes life-threatening disease. Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and entry. There a need small-animal models of MERS, but mice are not susceptible to MERS because murine dpp4 does serve as receptor. We developed transgenic expressing human DPP4 (hDPP4) under control surfactant protein C promoter or cytokeratin 18 that infection with MERS-CoV. Notably, hDPP4 progressive, uniformly fatal disease following...
Highlights•Fluvastatin effectively prevents lung adenocarcinoma bone metastasis in a nude mouse model.•Fluvastatin-induced anti-bone metastatic property was largely dependent on its ability to induce autophagy.•Fluvastatin-induced autophagy and activity are mediated by p53.Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, most frequently prescribed cholesterol-lowering agent with minimal side effects. In this study, we present novel function statins...
The metabolic syndrome is a constellation of risk factors, including abdominal obesity, hypertension, dyslipidemia, and hyperglycemia. Polycyclic aromatic hydrocarbons (PAHs) constitute group chemicals that are formed during the incomplete combustion coal, oil gas, garbage, other organic substances. In occupational exposure population, PAHs increased prevalence ratio syndrome. However, effect on in adolescents has not been reported. Because propensity for childhood to track into adulthood,...
Abstract Background Total and differential white blood cell counts are important for the diagnostic evaluation of suspected diseases. To facilitate interpretation total in pediatric patients, present study investigated age-dependent changes healthy reference children. Methods Data were obtained from Pediatric Reference Intervals China (PRINCE), which aims to establish verify intervals Chinese children based on a nationwide multicenter cross-sectional January 2017 December 2018. Quantile...
Purpose: Our study is aimed at exploring the association between peripheral artery disease (PAD) and metabolic syndrome (MetS) across different age gender groups among patients with Type 2 diabetes mellitus (T2DM). Patients Methods: A total of 3638 T2DM were enrolled in study, including 281 PAD 3357 without PAD. Demographic data anthropometric measurements, such as height, weight, waist circumference, collected. Laboratory tests ankle-brachial index (ABI) assessment also conducted. Multiple...
Purpose: To investigate the mechanism of chitosan promoting corneal wound healing though evaluating its effect on extracellular signal-regulated kinases (ERK) and p38 pathway activity in a rabbit animal model.Methods: Cell proliferation migration assay were performed 24 hours after treatment. The ERK pathways was detected by using immunofluorescence Western blotting presence an inhibitor. In vivo study epithelial debridement wounds 8 mm corneas inhibitor.Results: Immunostaining with Ki67...
Abstract Background Continuous reference intervals (RIs) allow for more precise consideration of the dynamic changes physiological development, which can provide new strategies presentation laboratory test results. Our study aimed to establish continuous RIs using four different simulation methods so that applicability could be further understood. Methods The data alkaline phosphatase (ALP) and serum creatinine (Cr) were obtained from Pediatric Reference Interval in China (PRINCE), healthy...
Abstract Background Atherosclerosis is a common complication in patients with type 2 diabetes (T2DM). Multiple factors are involved the development and progress of atherosclerosis. We evaluated association weekly sedentary time (WST) carotid plaque formation. Methods After data cleaning, total 26 664 participants T2DM from 10 National Metabolic Management Centers (MMCs) June 2017 to April 2021 were enrolled. Self‐reported lifestyle including WST, sleeping time, smoking drinking information,...
Objective: Aimed to evaluate the validity of five published equations that estimate 24-h urinary sodium excretion (24-h USE) by timed spot urine specimens. Methods: All urines within 24 h were collected from 99 healthy volunteers aged 21–57 years. The and USE measured. was estimated INTERSALT equation Tanaka with casual four (i.e. overnight, second morning, post meridiem, evening urine), Kawasaki SunSMU morning urine, SunPM meridiem respectively. At last, agreement between measured...
Bacteria in lung play an important role sustaining health. Understanding the characteristics of bacteriomes lesions pulmonary tuberculosis (TB) patients, who excrete Mycobacterium (MTB), is for TB prevention and effective treatment. METHODS: In this study, from patients excreting bacteria (TB-E) those not (TB-NE) with matched normal tissues (NT) were compared by 16S rRNA sequencing. Bacterial MetaCyc functions also predicted PICRUSt2 tool.Alpha diversity bacteria, including Chao 1 Shannon...
Background and Aims: This study is aimed at investigating the potential correlation of thyroid hormone sensitivity with visceral fat area (VFA), subcutaneous (SFA), body mass index (BMI) among euthyroid type 2 diabetes mellitus (T2DM) subjects.Methods: Thyroid indices were calculated by feedback quantile–based (TFQI), TSH (TSHI), thyrotropin thyroxine resistance (TT4RI), free (fT4)/free triiodothyronine (fT3) ratio. These then categorized into quartiles for analysis. The outcomes change...
Livin is a novel member of the inhibitor apoptosis protein family that has been reported to be overexpressed in various types human malignancy. Although several studies have demonstrated livin may used as an effective target for tumor therapy, few investigated its role lung adenocarcinoma. In present study, two different methods were order investigate tumor‑suppressing effect adenocarcinoma cells. Firstly, small interfering (si)RNA technology was down regulate expression; siRNA‑mediated...
This research aimed to study the role of ezrin, CD44, and VEGF in invasion, metastasis, recurrence, prognosis giant cell tumor bone (GCTB) its association with clinical pathological features GCTB. Expression status 80 GCTB tissues adjacent noncancerous tissue samples were measured immunohistochemical Elivison staining. Their correlation pathologic factors was statistically analyzed by chi-square test. The expression significantly higher than at Campanacci stage III stages I II (P < 0.05). No...
Tuberculosis meningitis (TBM) is one of the most severe forms tuberculosis. However, TBM diagnosis quite challenging due to nonspecific clinical presentation and paucity pathogen in cerebrospinal fluid (CSF) samples. In this study, we report a new method for detecting cell-free Mycobacterium tuberculosis DNA (cf-TB) CSF evaluate its value diagnosis.Of 68 patients prospectively recruited, 46 were diagnosed as having 22 non-TBM. We compared cf-TB with smear microscopy, mycobacterial culture,...
Background A data-based study reported the linear relationship between body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C) in a normal population. However, there were no studies giving suggestion for diabetes patients limited by sample size. This aimed to investigate non-linear dose-response BMI LDL-C type 2 mellitus (T2DM). Method The participants registered at National Metabolic Management Center (MMC) of Beijing Luhe hospital from June 2017 2021. T2DM was diagnosed...
Abstract Background This study aimed to construct an effective nomogram based on the clinical and laboratory characteristics predict prognosis of stage I lung adenocarcinoma with EGFR alteration. Methods A retrospective was performed 913 eligible patients alteration after surgery at Shanghai Pulmonary Hospital. The peripheral blood indicators were included in nomogram. Calibration plots, concordance index, decision curve analysis, X-tile software used this study. Recurrence-free survival...
Several recent studies have reported that a few patients had positive SARS-CoV-2 RNA tests after hospital discharge. The high-risk factors associated with these remain to be identified. A total of 463 COVID-19 discharged from Leishenshan Hospital in Wuhan, China, between February 8 and March 8, 2020 were initially enrolled, 351 at least 2 weeks follow-up finally included. Seventeen the for RNA. Based on clinical characteristics mathematical modeling, shorter stays less oxygen desaturation...
Caudate dopaminergic dysfunction is implied in the pathophysiology of patients with Parkinson's disease (PD). Still, connectivity specificities caudate nucleus (CN) subdivisions and effect dopamine are poorly understood. We collected MRI neuropsychological data from 34 PD 26 age- sex-matched healthy elderly individuals (HEs) this study. Resting-state functional analysis revealed that compared to other CN subdivisions, head was more strongly connected default mode network (DMN), body...
PURPOSE We aimed to determine the relationship of abnormal labyrinthine signals on heavily T2-weighted three-dimensional fluid-attenuated inversion recovery imaging (HF sequence) with hearing impairment and prognosis in patients sudden sensorineural loss (SSNHL). METHODS Patients unilateral SSNHL underwent magnetic resonance imaging, including pre-contrast HF sequences post-contrast a 4-hour scan delay after intravenous gadolinium injection. measured signal intensity ratio (SIR) vestibule...
This study aims to develop a nomogram for predicting vision-threatening diabetic retinopathy (VTDR) in type 2 diabetes mellitus (T2DM) with mild non-proliferative (NPDR) patients.In case-control analysis, 440 patients NPDR or VTDR were enrolled identify predictors and nomogram. In the prospective cohort, 120 T2DM external validation. Sensitivity, specificity, area under receiver operating characteristic (AUC) calculated evaluate predictive performance of nomogram.In 2-h C-peptide (OR = 0.85,...