A5066366965- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Bone Metabolism and Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related gene regulation
- RNA regulation and disease
- HIV Research and Treatment
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
- Cerebrospinal fluid and hydrocephalus
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Neurosurgical Procedures and Complications
- Gestational Diabetes Research and Management
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
National Clinical Research Center for Digestive Diseases
2018-2025
Tianjin Medical University Cancer Institute and Hospital
2015-2025
Shandong University
2010-2024
Yuhuangding Hospital
2016-2024
Capital Medical University
2014-2023
Xuan Wu Hospital of the Capital Medical University
2019-2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023
Guangzhou University of Chinese Medicine
2021-2023
China Medical University
2023
Qingdao University
2016-2020
The goal of this study was to explore the feasibility and accuracy using a wearable mixed-reality holographic computer guide external ventricular drain (EVD) insertion thus improve on classic freehand method for EVD insertion. authors also sought provide clinically applicable workflow demonstration.
Highlights•Fluvastatin effectively prevents lung adenocarcinoma bone metastasis in a nude mouse model.•Fluvastatin-induced anti-bone metastatic property was largely dependent on its ability to induce autophagy.•Fluvastatin-induced autophagy and activity are mediated by p53.Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, most frequently prescribed cholesterol-lowering agent with minimal side effects. In this study, we present novel function statins...
Context Little systematic data on male prolactinomas treated with surgery are available. Objective To clarify the clinical features and confirm efficacy of transsphenoidal for predictive factors after initial surgery. Patients methods This retrospective study included 87 patients prolactinoma by at an academic medical center. Hormonal visual status, remission rates, rate tumor relapse, as well factors, were evaluated. Results Postoperative was achieved in 52.9% patients. The markedly higher...
INTRODUCTION Acute fatty liver of pregnancy (AFLP) frequently causes failure in pregnant women.A better understanding the clinical characteristics, management, outcomes and risk factors AFLP is required, given its relatively high mortality rate.We aimed to describe characteristics AFLP, further assess potential from perspectives mother fetus. METHODSThis was a retrospective cohort study 133 patients with hospitalised at four tertiary hospitals China between January 2009 April 2014.RESULTS...
Abnormal activation of signal transducer and activator transcription 3 (STAT3) serves a pivotal role in oral squamous cell carcinoma (OSCC) tumor invasion into normal tissues or distant organs. However the downstream regulatory network STAT3 signaling remains unclear. The present study aimed to investigate potential mechanism underlying how triggers enhancer zeste homolog 2 (EZH2) expression inhibits microRNA (miR)-200a/b/429 SCC25 SCC15 cells vitro vivo. Western blotting reverse...
Abstract Background Gestational diabetes mellitus (GDM) is the most common medical complication associated with pregnancy, which may impose risks on both mother and fetus. Micro RNAs (miRNAs) long noncoding (lncRNAs) are implied as vital regulators in GDM. A recent paper revealed dysregulation of miR-33a-5p placental tissues GDM patients. However, biological function remains elusive. This study focused exploring underlying mechanisms Methods 12 pregnancies healthy were enrolled study. INS-1...
The aim of this study is to evaluate clinical data from a large cohort acromegalic patients with and without hyperprolactinemia. Between January 2002 June 2010, set on 279 undergoing transsphenoidal surgery was available. Based preoperative GH prolactin (PRL) levels, were divided into GH+PRL groups. A stabilization or further improvement postoperative changes in clinical, hormonal, immunohistochemical, magnetic resonance imaging parameters observed all throughout the follow-up period. group...
The present study aimed to investigate the role of microRNA-146a (miR-146a) in intracerebral hemorrhage (ICH), and further assess its underlying mechanism. An ICH rat model was established current 1 h following induction, rats were treated with or without an miR-146a mimic. A total 3 days neurological score, brain water content neuronal apoptosis measured via flow cytometry. Levels pro-inflammatory cytokines tumor necrosis factor-α interleukin-1β detected ELISA certain biomarkers oxidative...
<i >Objectives</i>. To study the correlation between methylation of protein kinase C epsilon zeta (PRKCZ) gene promoters and type 2 diabetes mellitus (T2DM). >Methods</i>. The case-control method was implemented in 272 unrelated to one another cases Shiyan People’s Hospital. Of those, 152 were diagnosed as T2DM cases, other 120 healthy individuals visiting hospital for a physical examination. subjects first divided into two groups: group normal control (NC) group. Next, methylated DNA...
Following the publication of above paper, and a corrigendum that has already been published (doi.org/10.3892/ijo.2023.5528) to attend errors were made in assembly Figs. 2 8, it was drawn Editor's attention by concerned reader two pairs data panels featuring overlapping existed comparing 1C 2D paper with Fig. journal Molecular Cancer Therapeutics, which before had submitted, even though this earlier did contain many same authors. Given further issue come light, owing number duplications...
Abstract Gestational diabetes mellitus (GDM) is associated with an increased risk of type 2 (T2DM) and cardiovascular diseases in later life, yet underlying mechanisms unclear. The present study was to explore the association upregulated histone deacetylase (HDAC 2) impaired mitochondrial function cytokine secretion monocytes/macrophages from GDM patients. In this study, we examined function, proinflamatory HDAC level serum or patients, investigated influence by inhibitor, AR‐42...
The long noncoding RNA HOTAIR (HOX transcript antisense intergenic RNA) has been reported to be a biomarker for various malignant tumors; however, its involvement in breast cancer is not fully understood. aim of this study was investigate the effects involved with and EZH2 (enhancer zeste homologue 2) on processes proliferation, invasion, migration, apoptosis cells.The expressions both normal human mammary epithelial cell (HBL-100) lines (MCF-7, MDA-MB-231, SKBR-3) were detected by means...
Intracerebral hemorrhage (ICH) is a common neurological condition associated with high disability and mortality. Alterations in protein ubiquitination have emerged as key mechanism the pathogenesis of diseases. Here, we investigated effects E3 ubiquitin ligase ring finger 34 (RNF34) on deficits brain injury ICH mice. An model was established via intracerebral injection autologous blood into wild-type RNF34 transgenic Brain injury, function, neuronal activity, oxidative stress levels were...