A5049578231- Cardiac Arrest and Resuscitation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Respiratory Support and Mechanisms
- Circular RNAs in diseases
- Mechanical Circulatory Support Devices
- Ubiquitin and proteasome pathways
- Bladder and Urothelial Cancer Treatments
- Retinal Diseases and Treatments
- Histone Deacetylase Inhibitors Research
- Artificial Intelligence in Healthcare
- Traumatic Brain Injury Research
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- Heart Rate Variability and Autonomic Control
- Cancer-related gene regulation
- Pain Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Acute Ischemic Stroke Management
Tianjin Medical University Cancer Institute and Hospital
2015-2025
Xijing Hospital
2024-2025
National Institutes for Food and Drug Control
2020-2025
Air Force Medical University
2024-2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
National Clinical Research Center for Digestive Diseases
2025
Changzhou Third People's Hospital
2025
Minzu University of China
2024
Hangzhou Normal University
2021-2024
Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma common neurodegenerative disease in which levels of NAD decline. We assess the effects nicotinamide (a precursor to NAD) on retinal ganglion cells (the affected neuron glaucoma) normal physiological conditions across range glaucoma relevant insults including mitochondrial stress axon degenerative insults. demonstrate cell somal, axonal, dendritic neuroprotection by rodent...
Deficient bioenergetics and diminished redox conservation have been implicated in the development of cerebral ischemia/reperfusion injury. In this study, mechanisms underlying neuroprotective effects cannabidiol (CBD), a nonpsychotropic compound derived from Cannabis sativa with FDA-approved antiepilepsy properties, were studied vitro using an oxygen–glucose-deprivation/reperfusion (OGD/R) model mouse hippocampal neuronal cell line. CBD supplementation during reperfusion rescued...
BACKGROUND Epinephrine has been shown to impair pulmonary excretion of CO2 during resuscitation. This phenomenon was investigated in a rodent model cardiac arrest and conventional METHODS AND RESULTS The effects racemic epinephrine were compared with the selective alpha 1-agonist methoxamine saline placebo resuscitation 15 Sprague-Dawley rats mechanically ventilated gas containing 70% oxygen. but not significantly increased coronary perfusion pressure from approximately 32 55 mm Hg....
Indirect measurement of gastric intramural pH (pHG) utilizing a luminal tonometer in the stomach has been proposed for monitoring severity and progression perfusion failure. In present study, we investigated PCO2 pHG as indicators quantitators failure experimental rodent model both hemorrhagic anaphylactic shock. Gastric (PGCO2) were directly measured with miniaturized sensors inserted into anterior wall stomach. shock, animals bled reservoir maintained at pressure 35 mmHg. decreased from...
It is widely held that mechanical ventilation essential for cardiopulmonary resuscitation (CPR). However, cardiac output and therefore pulmonary blood flow reduced to less than one-third of normal during CPR. We reasoned ventilatory requirements are correspondingly postulated gas exchange may be maintained precordial compression with oxygen passively delivered the airway in absence ventilation. After tracheal intubation, Sprague-Dawley rats were randomized. Fifteen animals on...
Quantitative measurement of regional blood flow during cardiac arrest and resuscitation has been confined to large animals. We report on a rodent model utilizing radioactive microspheres for investigation flow. Ventricular fibrillation was electrically induced in 10 pentobarbital-anesthetized Sprague-Dawley rats. Resuscitation attempted by precordial compression followed external direct current countershock. During compression, output corresponded 12% prearrest Similarly low flows were...
Homeobox (HOX) transcript antisense RNA (HOTAIR), a long nuclear-retained noncoding (lncRNA), is overexpressed in variety of human cancers. Increasing evidence shows that HOTAIR plays vital role cancer initiation and progression by affecting cell cycle progress, apoptosis invasion. However, whether serves as target therapeutic potential the underlying mechanism head neck squamous carcinoma (HNSCC) still unclear. Thus, we employed specific siRNA to deplete its expression two HNSCC lines,...
Spontaneous gasping is frequently observed during cardiac arrest, especially when mechanical ventilation withheld precordial compression. We related spontaneous to pulmonary gas exchange and resuscitability in a rodent model of arrest. Ventricular fibrillation was electrically induced 15 Sprague-Dawley rats. After 4 min untreated ventricular fibrillation, compression initiated. Coronary perfusion pressure maintained between 25 30 mm Hg. Oxygen supplied at the tracheal tube port coincident...
EZH2 is a negative prognostic factor and overexpressed or activated in most human cancers including head neck squamous cell carcinoma (HNSCC). Analysis of The Cancer Genome Atlas (TCGA) HNSCC data indicated that over-expression was associated with high tumor grade conferred poor prognosis. inhibition triggered apoptosis, cycle arrest decreased growth vitro. MICU1 (mitochondrial calcium uptake1) shown to be down regulated when expression inhibited HNSCC. When the were inhibited, cells became...
Abstract Background Long noncoding (lncRNA) single‐nucleotide polymorphisms (SNPs) are associated with the susceptibility to development of various malignant tumors. The aim this study was investigate roles HOX transcript antisense intergenic RNA ( HOTAIR ) and its SNPs in lung cancer. Methods Initially, expression different tumors investigated using online Gene Expression Profiling Interactive Analysis (GEPIA) resource. Three (rs920778, rs1899663, rs4759314) were identified MassArray...
Tissue plasminogen activator (tPA) is recommended by the FDA to dissolve intravascular clots after acute ischemic stroke (AIS). However, it may contribute hemorrhagic transformation (HT). The Wnt/β-catenin signaling pathway plays an important role in regulating blood-brain barrier (BBB) formation central nervous system. We explored whether glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (EX-4) reduces risk of HT rtPA treatment via using a rat transient middle cerebral artery...
Algae supplements are widely recognized for their nutritional benefits and commonly marketed as natural health products. However, concerns regarding contamination with cyanobacterial toxins have been raised. Moreover, there is very little data the potential of algal on Chinese market by these toxins. In this study, we employed a validated solid-phase extraction ultra-high-performance liquid chromatography-tandem mass spectrometry (SPE-UHPLC-MS/MS) method to analyze available in China....
Following the publication of above paper, and a corrigendum that has already been published (doi.org/10.3892/ijo.2023.5528) to attend errors were made in assembly Figs. 2 8, it was drawn Editor's attention by concerned reader two pairs data panels featuring overlapping existed comparing 1C 2D paper with Fig. journal Molecular Cancer Therapeutics, which before had submitted, even though this earlier did contain many same authors. Given further issue come light, owing number duplications...
Background: Diabetes retinopathy (DR) represents a microvascular disease in diabetes. Growth arrest-specific 1 (GAS1) is differentially expressed rat retinal Müller cells under high glucose (HG) conditions, and its promotion of ferroptosis contributes to cell death. However, the influence GAS1 DR elusive. Herein, we aimed investigate effect potential mechanism based on GAS1-mediated DR. Methods: After HG treatment, genes were analyzed by transcriptome sequencing followed Kyoto Encyclopedia...
Artificial intelligence makes strides in specialized diagnostics but faces challenges complex clinical scenarios, such as rare disease diagnosis and emergency condition identification. To address these limitations, we develop Meta General Practitioner (MetaGP), a 32-billion-parameter generative foundation model trained on extensive datasets, including over 8 million electronic health records, biomedical literature, medical textbooks. MetaGP demonstrates robust diagnostic capabilities,...
BACKGROUND After prolonged cardiac arrest, conventional methods of closed-chest compression are ineffective. This is primarily because failure to generate minimal threshold levels coronary perfusion pressure for resuscitation. report introduces a new option resuscitation by use combination intermittent ascending aortic balloon occlusion, infusion, and precordial increase the gradient perfusion. METHODS AND RESULTS Twenty anesthetized, mechanically ventilated, normovolemic domestic pigs were...
MicroRNA-205 (miR-205) was revealed as a novel diagnostic and prognostic biomarker for lung cancer, but the results in published papers were inconsistent. This meta-analysis aimed to investigate roles of miR-205 patients with cancer. Totally, 16 eligible articles included, among which 10 investigated value miR-205, 5 examined its values, 1 article studied both values. For meta-analysis, pooled sensitivity, specificity, positive likelihood ratio, negative odds overall area under curve cancer...
Tumor metastasis regulated by epithelial‑mesenchymal transition (EMT) plays a significant role in the development of human cancers, whereas molecular mechanisms this process head and neck squamous cell carcinoma (HNSCC) remain elusive. In study, we found that inhibition enhancer zeste homolog 2 (EZH2) resulted suppressed EMT HNSCC vitro vivo. We reported signal transducer activator transcription factor 3 (STAT3)/vascular endothelial growth receptor (VEGFR2) axis served as downstream...
Most current approaches applied for the essential identification of adulteration in edible vegetable oils are limited practical benefit because they require long analysis times, professional training, and costly instrumentation. The present work addresses this issue by developing a novel simple, accurate, rapid approach based on magnetic resonance relaxation fingerprints obtained from low-field nuclear spectroscopy measurements oils. six types oil, including flaxseed olive soybean corn...