A5102945102- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Quantum Dots Synthesis And Properties
- Dendrimers and Hyperbranched Polymers
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Plasmonic and Surface Plasmon Research
- Laser-Matter Interactions and Applications
- Renal and related cancers
- Advanced Optical Sensing Technologies
- Mass Spectrometry Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
Tianjin Medical University
2016-2025
Chongqing University
2025
Wenzhou Medical University
2024-2025
Hunan University
2024
University of Oklahoma Health Sciences Center
2023
Changchun University of Science and Technology
2012-2023
Nanchang University
2020-2021
Inner Mongolia People's Hospital
2019-2021
First Affiliated Hospital of Nanchang University
2020
Tianjin Medical University General Hospital
2013-2019
Exosomes are a class of naturally occurring nanoparticles that secreted endogenously by mammalian cells. Clinical applications for exosomes remain challenge because their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed dual-functional exosome-based superparamagnetic nanoparticle cluster as targeted drug delivery vehicle cancer therapy. The resulting exhibits behavior at room temperature, with stronger response to an external magnetic field...
The long non-coding RNA Hox transcript antisense intergenic (HOTAIR) was recently implicated in breast cancer metastasis and is predictive of poor prognosis colorectal pancreatic cancers. We discovered that HOTAIR a cell cycle-related lncRNA human glioma, its expression closely associated with glioma staging prognosis. Although lysine specific demethylase 1 (LSD1) polycomb repressive complex 2 (PRC2) have been demonstrated to be functional targets HOTAIR, how regulates cycle progression...
Abstract The prognosis of advanced oral squamous cell carcinoma (OSCC) patients remains dismal and a better understanding the underlying mechanisms is critical for identifying effective targets with therapeutic potential to improve survival OSCC. This study aims clarify clinical biological significance metastasis-associated long non-coding RNA, lung adenocarcinoma transcript 1 (MALAT1) in We found that MALAT1 overexpressed OSCC tissues compared normal mucosa by real-time PCR. served as new...
The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed molecular mediators involved in these processes. MCF-7 MDA-MB-231 were treated with culture conditioned medium, respectively. Cytokine antibody array, enzyme-linked immunosorbent assay, western blotting immunofluorescence used to identify key chemokines. Chromatin immunoprecipitation luciferase reporter...
Substantial data indicate that the oncogene microRNA 21 (miR-21) is significantly elevated in glioblastoma multiforme (GBM) and regulates multiple genes associated with cancer cell proliferation, apoptosis, invasiveness. Thus, miR-21 can theoretically become a target to enhance chemotherapeutic effect therapy. So far, of downregulating taxol has not been studied human GBM.Human U251 (PTEN-mutant) LN229 (PTEN wild-type) cells were treated inhibitor (in poly (amidoamine) (PAMAM) dendrimer),...
The extensive involvement of miRNAs in cancer pathobiology has opened avenues for drug development based on oncomir inhibition. Dicer is the core enzyme miRNA processing that cleaves terminal loop precursor microRNAs (pre-miRNAs) to generate mature duplexes. Using three-dimensional structure binding site pre-miR-21 oncomir, we conducted an silico high-throughput screen small molecules block miR-21 maturation. By this method, identified a specific small-molecule inhibitor miR-21, termed...
The successful of anti-cancer treatment are often limited by the development drug resistance. Recent work has highlighted involvement non-coding RNAs, microRNAs(miRNAs) in cancer development, and their possible evolution resistance been proposed. In this study, we combine taxol chemotherapy miR-21 inhibitor via polyamidoamine (PAMAM) dendrimers vector to evaluate effects combination therapy on suppression breast cells. 50% inhibitory concentration (IC50) values for were significantly...
// Xuan Zhou 1, 2, * , Yu Ren 3, Jing Zhang 4, Chuanbao 5, Kailiang 6 Lei Han 1 Lingping Kong 2 Jianwei Wei Luyue Chen Jingxuan Yang Qixue Wang Jianning Yuqi 7 Tao Jiang 5 Min Li Chunsheng Kang Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory Neuro-oncology, Neurological Institute, 300052, China The Otorhinolaryngology and Maxillofacial Oncology, Cancer Institute & Key Prevention Therapy, National Clinical Research Center Cancer, 300060, 3 Basic...
Abstract Purpose: PI3K and STAT3 are frequently activated in cancer progression. However, little is known about the underlying mechanisms by which regulate head neck squamous cell (HNSCC) growth. The lncRNA HOX transcript antisense RNA (HOTAIR) was found to modulate progression of HNSCC. In this study, we attempted establish correlation PI3K/STAT3/HOTAIR signaling with HNSCC its sensitivity toward platinum-based targeted anti-EGFR combination therapy. Experimental Design: We first analyzed...
Over 20% of cancer 'driver' genes encode chromatin regulators. Long noncoding RNAs (lincRNAs), which are dysregulated in various cancers, play a critical role dynamics and gene regulation by interacting with key epigenetic It has been previously reported that the lincRNA HOTAIR mediates recruitment polycomb repressive complex 2 (PRC2) leading to aberrant transcriptional silencing tumor suppressor glioma breast cancer. Thus, can serve as promising therapeutic target. Herein, we identified...
Combination therapy has been explored for advanced head and neck squamous cell carcinoma (HNSCC) owing to the limited efficacy of anti-epidermal growth factor receptor (EGFR) therapy. Increased expression glycosylation immune checkpoint molecules in tumors are responsible cetuximab refractoriness. The role programmed death ligand 2 (PD-L2), a PD-1, function is unclear. Here, we examined regulatory mechanism PD-L2 its antitumor immunity therapy.Single-cell RNA sequencing immunohistochemical...
miRNA nanocapsules are synthesized with enhanced stability for delivery high transduction efficiency, offering a novel class of vectors cancer therapy. As service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher is responsible content...
Nearly 25% of long intergenic non-coding RNAs (lincRNAs) recruit chromatin-modifying proteins (e.g., EZH2) to silence target genes. HOX antisense RNA (HOTAIR) is deregulated in diverse cancers and could be an independent powerful predictor eventual metastasis death. Yet, it challenging develop small molecule drugs block activity HOTAIR with high specificity a short time. Our previous study proved that the 5′ domain, but not its 3′ was function domain responsible for tumorigenesis...
Abnormalities in signal transducer and activator of transcription 3 (STAT3) are involved the oncogenesis oral squamous cell carcinoma (OSCC). MicroRNA-21 (miR-21) is an important gene expression regulator to OSCC. miR-21 induction by STAT3 has been reported multiple human cancers. In present study, we found that (-/p) was positively correlated with 60 OSCC samples. A reporter assay showed overexpression dependent on activation. WP1066, a small molecular inhibitor STAT3, used suppress cells....
Abnormal activation of STAT3 and miR-21 plays a vital role in progression invasion solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute cancer metastasis by regulating epithelial-mesenchymal transition (EMT). However, the STAT3/miR-21 axis CDK5 head neck squamous cell carcinoma remains unclear. We measured expression miR-21, EMT markers 60 HNSCC tumor samples. used Immunohistochemistry situ hybridization assay examine invasiveness HNSCC. clinical survival relevance...
MicroRNAs (miRNAs) are involved in the development of various types cancers. Dysregulation miR‑205‑5p has been reported human cancer. However, little is known concerning role renal cell carcinoma (RCC). The pr~esent study was designed to investigate RCC. expression measured clear (ccRCC) tissues and lines using RT‑qPCR. RCC were transfected with mimics. CCK‑8 assays, wound healing Matrigel invasion assays nucleosome ELISAs used assess effects on growth, migration, apoptosis, respectively....
Down-regulation of microRNA-21 (miR-21) can induce cell apoptosis and reverse drug resistance in cancer treatments. In this study, we explored the most effective schedule miR-21 inhibitor (miR-21i) Temozolomide (TMZ) combined treatment human glioma cells. Three tumor lines, U251 phosphatase tensin homologue (PTEN) mutant, LN229 (PTEN wild-type), U87 loss function), were subjected to evaluate antitumor effects deigned treatments (a predose miR-21i for 4/8 h then a subsequent TMZ treatment, or...