A5101959846- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Pomegranate: compositions and health benefits
- Gut microbiota and health
- Neurological Disorders and Treatments
- Sunflower and Safflower Cultivation
- Cytokine Signaling Pathways and Interactions
- Parkinson's Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Ginkgo biloba and Cashew Applications
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Piperaceae Chemical and Biological Studies
- Cardiomyopathy and Myosin Studies
- Adipose Tissue and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Epigenetics and DNA Methylation
- Phytochemicals and Antioxidant Activities
Shanghai Children's Hospital
2020-2025
Shanghai Jiao Tong University
2025
Louisiana State University
2025
Affiliated Hospital of Guizhou Medical University
2018-2024
Fujian Women and Children Hospital
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2021-2024
First Affiliated Hospital of Wannan Medical College
2021-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2019-2023
Jiangxi University of Traditional Chinese Medicine
2023
Shanxi University
2019-2023
It has been suggested that gut microbiota is altered in Type 2 Diabetes Mellitus (T2DM) patients.This study was to evaluate the effect of prebiotic xylooligosaccharide (XOS) on both healthy and prediabetic (Pre-DM) subjects, as well impaired glucose tolerance (IGT) Pre-DM.Pre-DM (n = 13) or 16) subjects were randomized receive g/day XOS placebo for 8-weeks. In Pre-DM body composition oral test (OGTT) done at baseline week 8. Stool from 8 analyzed characterization using Illumina MiSeq...
The gut microbiota is an important contributor to human health. Vegetable/fruit juices provide polyphenols, oligosaccharides, fiber and nitrate (beet juice), which may induce a prebiotic-like effect. Juice-based diets are becoming popular. However, there lack of scientific evidence their health benefits. It was our hypothesis that changes in the intestinal induced by juice-based diet play role Twenty healthy adults consumed only vegetable/fruit for 3 days followed 14 customary diet. On day 4...
To design a simple model to assess the effectiveness of measures prevent spread coronavirus disease 2019 (COVID-19) different regions mainland China.We extracted data on population movements from an internet company set and numbers confirmed cases COVID-19 government sources. On 23 January 2020 all travel in out city Wuhan was prohibited control disease. We modelled two key factors affecting cumulative number outside by 1 March 2020: (i) total people leaving during 20-26 2020; (ii) seed...
The objective of this study was to investigate prebiotic potential, chemical composition, and antioxidant capacity spice extracts. Seven culinary spices including black pepper, cayenne cinnamon, ginger, Mediterranean oregano, rosemary, turmeric were extracted with boiling water. Major constituents characterized by RP-HPLC-DAD method determined measuring colorimetrically the extent scavenge ABTS radical cations. Effects extracts on viability 88 anaerobic facultative isolates from intestinal...
Abstract Breast cancer (BC) leads to the highest mortality in women worldwide, characterized by inevitable proliferation and metastasis of BC cells. Mounting evidence confirm that lncRNAs play a significant role tumorigenesis development BC. lncRNA CERS6‐AS1 is novel discovery, its molecular mechanism has not been studied. In this study, it was discovered overexpressed tissues accelerated cell suppressed apoptosis Moreover, exploration uncovered there positive association between CERS6 (or...
MicroRNAs (miRNAs) are involved in the development of various types cancers. Dysregulation miR‑205‑5p has been reported human cancer. However, little is known concerning role renal cell carcinoma (RCC). The pr~esent study was designed to investigate RCC. expression measured clear (ccRCC) tissues and lines using RT‑qPCR. RCC were transfected with mimics. CCK‑8 assays, wound healing Matrigel invasion assays nucleosome ELISAs used assess effects on growth, migration, apoptosis, respectively....
Previous clinical studies showing that cinnamon spice lowers blood glucose levels had inconsistent results. To determine the effect of daily supplementation in an amount commonly used for seasoning on adults with obesity and prediabetes. Following a 2-week run-in period maintaining low polyphenol/fiber diet, 18 participants prediabetes underwent 10-week randomized, controlled, double-blind, crossover trial (mean age 51.1years; mean fasting plasma 102.9mg/dL). The were randomized to take...
The antioxidant activity (AA) of fruits and vegetables has been thoroughly investigated but less is known about the AA dietary supplements (DS). We therefore assessed three to five DS each from pomegranate, milk thistle, green tea, grapes, goji, acai using four widely used standard methods. secondary objective was determine effects in vitro digestion on their AA. prior ranked as follows: pomegranate > resveratrol tea grape seed thistle very low goji with significant group variability after...
DNA barcoding is a promising species identification method, but it has proved difficult to find standardized marker in plant. Although the ITS/ITS2 RNA transcript been proposed as core barcode for seed plants, criticized being too conserved some provide enough information or variable align within different taxa ranks. We selected 30 individuals, representing 16 and four families, explore whether ITS2 can successfully resolve terms of secondary structure. Secondary structure was predicted...
Glycoprotein nonmetastatic melanoma B (Gpnmb) is a type I transmembrane protein implicated in cell differentiation, inflammation, tissue regeneration, and tumor progression. Gpnmb, which highly expressed glioblastoma cells, potential therapeutic target. However, little known about its expression, cellular localization, roles non-tumorous neural tissues. In this study, we examined Gpnmb expression the central nervous system of adult rats under both normal inflammatory conditions. Reverse...
Purpose: ORM1-like 3 (ORMDL3) belongs to a highly conserved protein family which is anchored as transmembrane in the endoplasmic reticulum.Gasdermin B (GSDMB) adjacent ORMDL3 on chromosome 17q21.2and gasdermin-domain containing (GSDM family).Recent reports suggest that GSDMB and are associated with asthma several populations.However, genetic association studies examined of gene variants showed conflicting results.To assess whether combined evidence shows between GSDMB/ORMDL3 polymorphism...
miR-148-3p and miR-152-3p as the tumor suppressors have been reported in various cancer types. Our study is aimed to discuss synergistic effect of prostate (PCa).
Triple-negative breast cancer (TNBC) cannot be treated with current hormonal therapies and has a higher risk of relapse than other cancers. To identify potential therapeutic targets for TNBC, we conducted microRNA sequencing (RNA-Seq) in human TNBC specimens tumor-matched controls. We found that growth differentiation factor-10 (GDF10), member the TGF-β superfamily, was downregulated tumor samples. Further analysis GDF10 expression larger set clinical samples using qPCR confirmed its...
Avocados contain fiber, lutein, and vitamin E, they are a rich source of MUFAs. The effect including an avocado daily as part hypocaloric weight-loss diet on weight loss is not known. aim this study was to determine the consumption loss, body composition, satiety, biomarkers inflammation, intestinal microbiota composition. In randomized, parallel-controlled, open-label, 2-arm intervention study, 51 healthy overweight/obese women men were assigned with 1 Hass (AVO; n = 24) or (CTRL; 27)...
Spices are rich in natural antioxidants and have been shown to be potent inhibitors of lipid peroxidation during cooking meat. Turmeric contains unique conjugated curcuminoids with strong antioxidant activity. Piperine, one the main constituents black pepper, is known increase bioavailability mouse human studies when consumed turmeric. We investigated whether adding pepper turmeric powder may further inhibit added meat patties prior cooking. The addition significantly decreased hamburger...
In vitro and animal studies have demonstrated that topical application oral consumption of pomegranate reduces UVB-induced skin damage. We therefore investigated if will reduce photodamage from UVB irradiation alter the composition microbiota in a randomized controlled, parallel, three-arm, open label study. Seventy-four female participants (30-45 years) with Fitzpatrick type II-IV were randomly assigned (1:1:1) to 1000 mg extract (PomX), 8 oz juice (PomJ) or placebo for 12 weeks. Minimal...
Spices were used as food preservatives prior to the advent of refrigeration, suggesting possibility effects on microbiota. Previous studies have shown prebiotic activities in animals and vitro, but there has not been a demonstration or postbiotic at culinary doses humans. In this randomized placebo-controlled study, we determined twenty-nine healthy adults gut microbiota consumption daily capsules containing 5 g mixed spices by comparison matched control group consuming maltodextrin placebo...
Grapes provide a rich source of polyphenols and fibers. This study aimed to evaluate the effect daily consumption 46 g whole grape powder, providing equivalent two servings California table grapes, on gut microbiome cholesterol/bile acid metabolism in healthy adults. included 4-week standardization low-polyphenol diet, followed by 4 weeks powder while continuing diet. Compared baseline, significantly increased alpha diversity index microbiome. There was trend increasing Verrucomicrobia (p =...
Introduction Social media' impact on loneliness has attracted widespread scholarly attention. One hypothesis is that active social media use (ASMU) associated with a decrease in loneliness. However, several empirical studies did not find significant correlation between ASMU and loneliness, may even increase This study explored the mechanism of double-edged sword effects Methods Data were collected through convenience sampling from three universities China. A total 454 Chinese college users...