A5064630704- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Family and Disability Support Research
- Infant Development and Preterm Care
- Children's Physical and Motor Development
- Child Nutrition and Feeding Issues
- Congenital heart defects research
- Child Development and Digital Technology
- Nerve injury and regeneration
- Infant Health and Development
- Attention Deficit Hyperactivity Disorder
- Genomic variations and chromosomal abnormalities
- Virology and Viral Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Peptidase Inhibition and Analysis
- Hearing Loss and Rehabilitation
- Health, Environment, Cognitive Aging
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Magnesium in Health and Disease
- Lipid metabolism and disorders
- Calcium signaling and nucleotide metabolism
Nagoya City University
2001-2021
Mizuho (Japan)
2021
Komatsu University
2019
Child Development Center
2015
Nagoya Central Hospital
2014
Nagoya City University Hospital
2012-2013
Hamamatsu University School of Medicine
2007-2012
Hamamatsu University
2007-2010
Hamamatsu Medical Center
2008
Mitochondrial dysfunction (MtD) has been observed in approximately five percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-dependent processes such as neurodevelopment, thereby contributing to autism. Most the previous studies have restricted biomarkers energy metabolism, while most genetic based on mutations mitochondrial DNA (mtDNA). Despite mtDNA, proteins essential for replication and function are encoded by genomic DNA; so far, there very few those...
Mitochondrial dysfunction (MtD) and abnormal brain bioenergetics have been implicated in autism, suggesting possible candidate genes the electron transport chain (ETC). We compared expression of 84 ETC post-mortem brains autism patients controls. Brain tissues from anterior cingulate gyrus, motor cortex, thalamus (n = 8) controls 10) were obtained Autism Tissue Program, USA. Quantitative real-time PCR arrays used to quantify gene expression. observed reduced several Eleven Complex I, five...
Abstract An investigation of genetic structures underlying autistic traits was performed with samples from twins for which at least one proband had been ascertained as having autism spectrum disorders (ASDs) in our catchment area. In order to adjust recent concepts autism, we employed criteria the broad disease and childhood rating scale (CARS) quantitative assessment. The CARS test on 45 twin pairs (19 monozygotic, 26 dizygotic) detected a regional routine screening system. obtained scores...
Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities of serotonergic neurotransmission have been reported autism. Serotonin transporter (SERT) modulates serotonin levels, and major therapeutic target Factors that regulate SERT expression might be implicated the pathophysiology One candidate regulatory protein roundabout axon guidance molecule, ROBO. SerT Drosophila regulated by robo; it plays vital role mammalian neurodevelopment also. Here, we examined...
Previous studies have reported the association between advanced paternal age at birth and risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability.To test whether an is found high-functioning (i.e. without disability).A case-control study was conducted Japan. The participants consisted individuals full-scale IQ>or=70, a DSM-IV autistic or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages divided into tertiles...
Autism spectrum disorders (ASD) are life-long neurodevelopmental conditions. The pathophysiology is poorly understood, and the clinical diagnosis can only be made through behavioural assessments. prevalence of ASD has increased eight-fold over last three decades. Paralleling this rise, research interest in disorder been accumulating, centering on two aspects: risk factors that would explain increase prevalence, precursors could predict an emergence prior to 2 years age. As regard responsible...
Poor motor skills and differences in sensory processing have been noted as behavioral markers of common neurodevelopmental disorders. A total 171 healthy children (81 girls, 90 boys) were investigated at age 3 to examine relations between temperament, processing, coordination. Using the Japanese versions Children's Behavior Questionnaire (CBQ), Sensory Profile (SP-J), Little Developmental Coordination Disorder (LDCDQ), this study examines an expanded model based on Rothbart's three-factor...
The neurobiological basis of autism remains poorly understood. diagnosis is based solely on behavioural characteristics because there are currently no reliable biological markers. To test whether the anterior pituitary hormones and cortisol could be useful as markers for autism, we assessed basal serum levels these in subjects with normal controls.Using a suspension array system, determined six hormones, including adrenocorticotropic hormone growth hormone, 32 drug-naive (aged 6 to 18 years,...