A5103080180- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Virus-based gene therapy research
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
- Ethics and Legal Issues in Pediatric Healthcare
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cancer therapeutics and mechanisms
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Adrenal and Paraganglionic Tumors
- Gestational Trophoblastic Disease Studies
- Teratomas and Epidermoid Cysts
- Vascular Malformations and Hemangiomas
- Vitamin C and Antioxidants Research
- Histiocytic Disorders and Treatments
- Electrolyte and hormonal disorders
- Testicular diseases and treatments
- Intestinal Malrotation and Obstruction Disorders
- Cancer-related Molecular Pathways
- Genetic Syndromes and Imprinting
- Multiple and Secondary Primary Cancers
SAGA Heavy Ion Medical Accelerator in Tosu
2019-2023
Toronto General Hospital
2010
Chiba Cancer Center
2001
Children's Hospital of Philadelphia
1995-1997
University of Pennsylvania
1995
Kyushu University
1980-1992
Li-Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant inheritance. LFS develops in individuals with pathogenic germline variant of the cancer-suppressor gene, TP53 (individuals variant). The number among general population said to be 1 500 20,000. Meanwhile, it found 1.6% (median value, range 0-6.7%) patients pediatric cancer and 0.2% adult cancer. diagnosed by presence variants. However, can still even absence if familial history cancers fit classic diagnostic...
A 14-year-old girl with numerous café-au-lait spots in her skin was hospitalized because of fever, weight loss, and a mass the right upper quadrant abdomen. Despite intensive chemotherapy, she died 6 months after admission. The autopsy revealed adrenal tumor metastases to liver, lungs, vertebrae, lymph nodes. Histologically pheochromocytoma small foci ganglioneuroblastoma. catecholamine contents were markedly elevated, as confirmed by fluorescence technique. Electron microscopically, cells...
Two extraskeletal myxoid chondrosarcomas with a solid soft tissue mass occurred on the right upper arm of 4-year-old boy and chest wall 1-year-old boy. Microscopically, both tumors were characterized by lobular configuration sparsely cellular background matrix. The cells small round, appeared undifferentiated, sometimes narrow eosinophilic cytoplasm. They grew in nests or strands single file. strongly positive for S-100 protein vimentin. Ultrastructural features suggested that had poorly...
We examined the expression of ret proto‐oncogene (proto‐ ) in surgically resected human neuroblastomas. Slot blot RNA hybridization revealed that all 29 neuroblastomas expressed proto‐ , relative intensity ranging from 1 to 48. No correlation was found between level and clinical stage. The also not correlated with N‐ myc amplification, patient's age or histological type tumor. Based on previous finding is very rarely detected tumor cell lines other than those neuroblastoma, suggested be a...
In Asia, a few countries have long and established history of collaborative clinical trials successfully formed national children's cancer study groups, but many still do not such groups. The process forming groups is fraught with hurdles, which varies among the countries. One basic requirements for running an affordable health care system in most children can receive proposed treatment. insurance coverage from <20% to as high 100% Asian countries, operation must also be adjusted...
A selective expression of suicide gene(s) in tumor cells should produce a preferential cytotoxic effect on tumors. Promoter region(s) gene that is expressed tumors but not normal tissues can be useful for tumor-specific transcription gene. Midkine (MK), growth/differentiation factor, predominantly various types human tumors, whereas its adult highly restricted. In our study, we showed 2.3-kb fragment genomic DNA the 5′ upstream region MK could activate fused reporter MK-positive MK-negative...
We have investigated the relationship between expression of bcl-2 and myc family genes in primary human neuroblastoma (NB) tumors cell lines. Of 20 NB examined, transcripts were expressed at variable levels 16 all clinical stages. 2 with N-myc amplification, one a high level, whereas other did so low level. In contrast, showed c-myc and/or transcripts. Similarly, 9 lines amplification 6 levels, 3 it barely detectable levels. The without also protein All tested either or protein. These data...
We examined 52 children with advanced neuroblastoma who were diagnosed and treated during the past 7 years, investigated correlation between degree of lymph node (LN) metastasis prognosis neuroblastoma. In 8 patients, distant LN was confumed both radio-graphically histologically. The urinary homovanillic acid (HVA) level markedly elevated in these it higher than that patients regional (P <.05). vanillylmandelic (VMA) VMA/HVA ratio not significantly different metastasis. None four showed...
Around 60–70% of the world population are residing in Asia and each year approximately 200,000–250,000 children young adolescents aged less than 20 years expected to develop cancer. The Asian continental branch International Society Pediatric Oncology (SIOP Asia) was founded 1995 its first meeting held Singapore 2000. Since SIOP is an academic society under umbrella SIOP, foundation action team named as Hematology Group (APHOG) proposed agreed be built by representatives from many countries...
Histochemical staining and biochemical assay of acetylcholinesterase (AChE) activity were applied to rectal suction biopsy tissue from patients treated by Z-shaped anastomosis for Hirschsprung's disease. Postoperative AChE AChE/Total ChE (% AChE) in the anterior wall significantly higher (p < 0.001) than those posterior wall. Biochemical was well correlative visual mucosal activity. It is remarkable that n after found be kept at high level a long period without any relation time interval...
Quantitative lipoprotein-X (Lp-X) was measured for diagnostic and postoperative examination of congenital biliary atresia (CBA). There no significant difference in the levels children with CBA (n=23) or neonatal hepatitis (NH) (n=14). However, a value over 200 mg/dl found 7 but not NH patients. As to 13 non-icteric patients CBA, Lp-X absent only 2 Thus, without jaundice do always have normal secretion. From those results, estimation is both useful diagnosis evaluation CBA.