A5027083178- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Signaling Pathways in Disease
- Cancer therapeutics and mechanisms
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Nerve injury and regeneration
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Neuroendocrine Tumor Research Advances
- Axon Guidance and Neuronal Signaling
- Neurofibromatosis and Schwannoma Cases
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Silk-based biomaterials and applications
- Hemoglobin structure and function
- Erythrocyte Function and Pathophysiology
- Wnt/β-catenin signaling in development and cancer
- Protein Hydrolysis and Bioactive Peptides
- Glycosylation and Glycoproteins Research
- Biochemical effects in animals
- Lung Cancer Research Studies
- RNA Interference and Gene Delivery
- Chromatin Remodeling and Cancer
University of Illinois Chicago
2014-2024
Stanford University
2019-2020
Oslo University Hospital
2020
Children's Hospital of Los Angeles
2019
Tufts University
2019
Illinois College
2011-2018
Children's Healthcare of Atlanta
2006
Emory University
2006
Children's Hospital of Philadelphia
1989-2003
University of Pennsylvania
1989-2000
MYCN amplification with subsequent protein overexpression is a powerful indicator of poor prognosis neuroblastoma patients. Little known regarding the prognostic significance homologous MYC expression in neuroblastoma. Immunostaining for and was performed on 357 undifferentiated/poorly differentiated neuroblastomas. Results were analysed other markers. Sixty-seven (19%) tumours MYCN(+), 38 (11%) MYC(+), one(0.3%) had both proteins(+). MYCN(+) MYC(+) more likely diagnosed children>18months...
This study sought to investigate biological/clinicopathological characteristics of neuroblastoma, undifferentiated subtype (NBUD).This examined 157 NBUD cases filed at the Children's Oncology Group Neuroblastoma Pathology Reference Laboratory, and survival rates patients were analyzed with known prognostic factors. Immunostainings for MYCN MYC protein performed on 68 tumors.NBUD had a poor prognosis (48.4% ± 5.0% 3-year event-free [EFS]; 56.5% overall [OS]), often associated high...
PURPOSE: Neurotrophins and their receptors regulate the proliferation, differentiation, death of neuronal cells, they have been implicated in pathogenesis prognosis neuroblastomas medulloblastomas. Tyrosine kinase (Trk) also are expressed extraneural tissues. PATIENTS AND METHODS: To study role neurotrophin ligands Wilms’ tumor (WT), we determined expression by semiquantitative duplex reverse transcriptase polymerase chain reaction 39 patients with primary WT. Comparison mRNA levels clinical...
Increased N-myc (now designated NMYC in human gene nomenclature) expression has been detected at the transcriptional level certain types of neoplasms. As yet, product not identified. To detect and characterize product, we have developed monoclonal antibodies against putative made Escherichia coli as a fusion protein. The that recognize N-myc-specific regions were selected on basis their reactivities to different portions These pair closely migrating polypeptides 60 63 kDa nuclear fractions...
Abstract MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance expression in clinical and biological behavior neuroblastoma has been unclear. To address this question, we first examined combination with TrkA (a favorable prognostic indicator neuroblastoma) 91 primary by quantitative reverse transcription-PCR investigated relationship among patient survival, MYCN, expressions. Three subsets were defined based on expression. Neuroblastoma expressing...
Neuroblastoma (NB) is a common pediatric tumor that exhibits wide range of biological and clinical heterogeneity. EPH (erythropoietin-producing hepatoma amplified sequence) family receptor tyrosine kinases ligand ephrins play pivotal roles in neural cardiovascular development. High-level expression transcripts encoding EPHB6 receptors (EPHB6) its ligands ephrin-B2 ephrin-B3 (EFNB2, EFNB3) associated with low-stage NB (stages 1, 2, 4S) high TrkA expression. In this study, we showed EFNB2...
Cancer stem cells (CSCs) are plastic in nature, a characteristic that hampers cancer therapeutics. Neuroblastoma (NB) is pediatric tumor of neural crest origin, and half the cases highly aggressive. By treating NB cell lines [SKNAS, SKNBE(2)C, CHP134, SY5Y] with epigenetic modifiers for short time, followed by sphere-forming culture conditions, we have established cell–like phenotypically stable more than year. These characterized their high expression stemness factors, markers, open...
Abstract Neuroblastoma (NB) tumor substantially contributes to childhood cancer mortality. The design of novel drugs targeted specific molecular alterations becomes mandatory, especially for high‐risk patients burdened by chemoresistant relapse. dysregulated expression MYCN , ALK and LIN28B the diminished levels miR‐34a let‐7b are oncogenic in NB. Due ability miRNA‐mimics recover suppression functions miRNAs underexpressed into cells, safe efficient nanocarriers selectively NB cells tested...