A5101660371- Advanced Battery Materials and Technologies
- RNA Interference and Gene Delivery
- Advancements in Battery Materials
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
- Supercapacitor Materials and Fabrication
- Advanced battery technologies research
- Intensive Care Unit Cognitive Disorders
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Greenhouse Technology and Climate Control
- Cell death mechanisms and regulation
- Nerve injury and regeneration
- Immune Response and Inflammation
- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Advanced Battery Technologies Research
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Acute Kidney Injury Research
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
- Lipid metabolism and disorders
- Medical Research and Treatments
Chinese Academy of Agricultural Sciences
2023-2025
Farmland Irrigation Research Institute
2023-2025
Shandong University
2014-2024
Ministry of Agriculture and Rural Affairs
2024
China Medical University
2024
Shandong Provincial Hospital
2014-2023
Shandong First Medical University
2021-2023
Center for Life Sciences
2022
Peking University
2022
Beijing National Laboratory for Molecular Sciences
2022
To assess the number of adult critical care beds in Asian countries and regions relation to population size.Cross-sectional observational study.Twenty-three regions, covering 92.1% continent's population.Ten low-income lower-middle-income economies, five upper-middle-income eight high-income economies according World Bank classification.Data closest 2017 on beds, including ICU intermediate unit were obtained through multiple means, government sources, national societies, colleges, or...
Zn metal as one of promising anode materials for aqueous batteries suffers from notorious dendrite growth, serious corrosion and hydrogen evolution. Here, a bifunctional electrolyte additive, N-methyl pyrrolidone (NMP), is developed to improve the electrochemical performance anode. NMP not only alters solvation structure Zn2+ , but also in situ produces dense N-rich solid-electrolyte-interphase layer on foils. This protects foils corrosive electrolytes benefits uniform plating/stripping Zn....
Zn metal as one of the promising anodes aqueous batteries possesses notable advantages, but it faces severe challenges from side reactions and notorious dendrite growth. Here, ultrathin nanosheets α-zirconium phosphate (ZrP) are explored an electrolyte additive. The not only create a dynamic reversible interphase on also promote Zn2+ transportation in electrolyte, especially outer Helmholtz plane near ZrP. Benefited enhanced kinetics interphase, pouch cells Zn||LiMn2 O4 using this remarkably...
Alloy-based Sn anode for sodium-ion batteries has attracted tremendous attention due to its low working voltage, high specific capacity, and good availability. Its application is hindered, however, by inferior cycling stability huge volume changes unstable solid-electrolyte interphase (SEI) film. Herein, tetraphenylphosphonium bis(trifluoromethanesulfonyl)imide (TPPTFSI) introduced into the electrode spontaneously adsorbed on surfaces of commercial microparticles (μ-Sn) improve...
Abstract Objectives Aconitine, the natural product extracted from Aconitum species, is widely used for treatment of various diseases, including rheumatism, arthritis, bruises, fractures and pains. However, many studies have reported cardiotoxicity neurotoxicity caused by aconitine, but detailed mechanism underlying aconitine's effect on these processes remains unclear. Materials methods The effects aconitine inflammation, apoptosis viability H9c2 rat cardiomyocytes were evaluated flow...
Abstract Background Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, current medical methods have limited therapeutic effects. The present study aimed to find out molecular mechanism AKI pathogenesis, may provide new insights for future therapy. Methods Bioinformatic analysis was conducted using R language (AT&T BellLaboratories, University Auckland, New Zealand) acquire differentially expressed long noncoding RNAs (lncRNAs) and...
Abstract Dual‐ion batteries have shown promising prospect in energy storage, owing to their low material costs, high power capability, and environmental friendliness. However, graphite as the cathode always suffers from structural damage electrode/electrolyte interface instability, which greatly deteriorate electrochemical performance. Here, tris(trimethyl‐silyl) phosphite (TMSP) is added an electrolyte additive improve TMSP not only scavenges deleterious species generated by electrolytes,...
TiO 2 is used as a model to illustrate the binder chemistry in ethers by polyvinylidene difluoride (PVdF) and sodium carboxymethyl cellulose (CMC). The worse performance of PVdF due defluorination reaction adhesion loss.
Pattern-recognition receptors (PRRs) have been shown to promote tumour metastasis via sensing cell-derived small extracellular vesicles (EVs). Nucleotide-binding oligomerisation domain 1 (NOD1), a cytoplasmic PRR, plays role in colorectal cancer (CRC) by detecting bacterial products. However, the precise mechanisms underlying effects of NOD1, following identification CRC EVs (CRC-EVs), potentiate liver (CRC-LM), remain poorly understood. Here, we demonstrate that CRC-EVs activate NOD1...
Here, we investigated the molecular mechanism underlying changes in distribution of nucleolin. Our study identified PI3K/Akt signaling as an essential pathway regulating Furthermore, nucleolin can interact with phospho‐PI3K‐p55, and were related to its phosphorylation. Subsequently, analyzed correlation VEGF nucleolin, found that metastatic potential. Finally, blocking cell surface influences process epithelial–mesenchymal transitions. This indicates may be a novel cancer therapy target...
Background In this study, we investigated whether the infusion of bone marrow-derived mesenchymal stem cells (MSCs), combined with transient immunosuppressant treatment, could suppress allograft rejection and modulate T-cell regulation in a swine orthotopic hemi-facial composite tissue allotransplantation (CTA) model. Methodology/Principal Findings Outbred miniature underwent (day 0). Group-I (n = 5) consisted untreated control animals. Group-II 3) animals received MSCs alone (given on days...
Background: Since 1990s, directly observed therapy (DOT) has been the standard-of-care for tuberculosis (TB), although it is cumbersome patients as well service providers. For raising implementation, an alternative delivery method with good potential telehealth. The current study assessed clinical and cost benefit of video (VDOT), compared DOT service. Methods: This prospective randomized controlled trial adults bacteriologically confirmed pulmonary TB to intervention (VDOT) or control...
Anode materials with a high initial coulombic efficiency and long lifespan are highly desirable for sodium-ion batteries. Here, bimetallic μ-BiSn microspheres well combine the capacity of Sn good stability Bi together, exhibiting superior electrochemical performance, such as Coulombic (90.6%), cycling (541 mA h g-1 after 3000 cycles at 2 A g-1) an excellent rate capability (393 10 g-1).
Abstract TiO 2 ‐based materials are considered to be the promising anodes of sodium‐ion batteries (NIBs) because their high safety and good stability. However, low specific capacity operating voltage plateau impose a severe challenge for energy density batteries. Herein, interconnected micro‐sheets consisting carbon nanotubes sulfur doped (CNT/S‐TiO ) synthesized via an ultrasonic process subsequent calcination, enabling fabrication high‐performance material. The utilization SWCNT overcomes...
Abstract Purpose: Human neutrophil peptides (HNP1-3), small molecular antimicrobial peptides, are expressed within tumors and associated with tumor necrosis inhibition of angiogenesis. Recent investigations have suggested that HNP1-3 likely to be involved in the host immune responses tumors. Experimental Design: We used recombinant pSec-HNP1, which expresses a secretable form HNP1, obtain expression HNP1 milieu immunocompetent mice explore possible roles immunity. The antitumor effects were...
O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation is a ubiquitous protein post-translational modification of the emerging importance in metazoans. Of thousands O-GlcNAcylated proteins identified, many carry multiple sites with varied stoichiometry. To better match scale O-GlcNAc and their dynamic nature, we herein report an optimized strategy, termed isotopic photocleavable tagging for profiling (isoPTOP), which enables quantitative site-specific O-GlcNAcylation excellent specificity...
The altered expression of long non-coding RNAs (lncRNAs) is often related to carcinogenesis, metastasis and resistance radiation or chemotherapy. In the current study, cDNA microarray analysis found that NEAT1 was reduced in nasopharyngeal carcinoma (NPC) patients it regulated NPC progression. However, detailed mechanisms were unclear. repressed cell growth, invasion vitro tumor vivo. addition, results an approach integrating bioinformatics, luciferase reporter assays RNA immunoprecipitation...
A noncleavable paclitaxel (PTX) and N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) derivative conjugate, 22 (DY-16-43), its analogues were prepared characterized as antagonists of NOD2 signaling. This conjugate enhanced the antitumor antimetastatic efficacy PTX in Lewis lung carcinoma (LLC) tumor-bearing mice. work first describes a molecular strategy that enables sensitization chemotherapeutic response via antagonizing inflammatory signaling suggests antagonist potential adjunct treating...