A5100442081- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Bone Tissue Engineering Materials
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Musculoskeletal synovial abnormalities and treatments
- Cancer Cells and Metastasis
- Systemic Lupus Erythematosus Research
- Dental Implant Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Magnesium Alloys: Properties and Applications
- Cardiovascular Function and Risk Factors
- Barrier Structure and Function Studies
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Ear and Head Tumors
- Graphene and Nanomaterials Applications
- Gastrointestinal Tumor Research and Treatment
The University of Texas MD Anderson Cancer Center
2007-2025
Sun Yat-sen University
2006-2025
University of Hong Kong
2016-2025
Nanjing Medical University
2006-2025
Xiamen University of Technology
2024-2025
Shanghai University
2025
Taiyuan University of Technology
2021-2025
Tibet University
2023-2025
Guangdong Provincial Academy of Environmental Science
2025
University of Hong Kong - Shenzhen Hospital
2018-2024
Abstract Despite the widespread observations on osteogenic effects of magnesium ion (Mg 2+ ), diverse roles Mg during bone healing have not been systematically dissected. Here, we reveal a previously unknown, biphasic mode action in repair. During early inflammation phase, contributes to an upregulated expression transient receptor potential cation channel member 7 (TRPM7), and TRPM7-dependent influx monocyte-macrophage lineage, resulting cleavage nuclear accumulation TRPM7-cleaved kinase...
Rational regulation of active hydrogen (*H) behavior is crucial for advancing electrocatalytic nitrate reduction reaction (NO3RR) to ammonia (NH3), yet in‐depth understanding the *H generation, transfer, and utilization remains ambiguous, explorations dynamic optimization are urgently needed. Herein we engineer a Ni3N nanosheet array intimately decorated with Cu nanoclusters (NF/Ni3N‐Cu) remarkably boosted NO3RR. From comprehensive experimental theoretical investigations, moieties favors...
Understanding cell-biomaterial interactions is critical for the control of cell fate tissue engineering and regenerative medicine. Here, cerium oxide nanoparticles (CeONPs) are applied at different Ce4+/Ce3+ ratios (i.e., 0.46, 1.23, 3.23) to titanium substrate surfaces by magnetron sputtering vacuum annealing. Evaluation cytotoxicity modified surface cultured rat bone marrow mesenchymal stem cells (BMSCs) reveals that cytocompatibility proliferation proportional increases in ratio on...
Taxonomy of a tetrigid genus Macromotettix Günther is reviewed. Two new species, undulatifemura Deng sp. nov. and sichuanensis are described from China. An updated identification key to all known species the given.
Abstract Bone formation induced by divalent metal cations has been widely reported; however, the underlying mechanism is unclear. Here we report that these stimulate skeleton interoception promoting prostaglandin E2 secretion from macrophages. This immune response accompanied sprouting and arborization of calcitonin gene-related polypeptide-α + nerve fibers, which sense inflammatory cue with PGE 2 receptor 4 convey interoceptive signals to central nervous system. Activating downregulates...
The most critical factor determining the success of biodegradable bone implants is host tissue response, which greatly depends on their degradation behaviors. Here, a new magnesium-based implant, namely magnesium-silicon-calcium (Mg-0.2Si-1.0Ca) alloy, that coordinates its biodegradation along with regenerative process via self-assembled, multilayered bone-implant interface designed. At first, rapid biocorrosion contributes to burst release Mg2+ , leading pro-osteogenic immune...
The photocatalytic process employing nanostructured semiconductor materials has attracted great attention in energy production, CO2 reduction, and water/air purification for decades. Recently, applying heterogeneous photocatalyst the synthesis of valuable chemicals is gradually emerging considered as a promising conversion cheap resources (i.e., biomass derivatives, polyols, aromatic hydrocarbons). Compared with traditional thermal catalytic approaches, provides mild reaction condition...
Abstract Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal COVID-19 is known, even though inflammatory diseases respiratory tract known to perturb bone metabolism and cause pathological loss. In this study, we characterize effects acute syndrome coronavirus 2 (SARS-CoV-2) infection an established golden Syrian hamster model for COVID-19....
Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), periodontitis, impacting people's health quality life. It well-established that IFN-Is affect immune responses factors by regulating some signaling. However, currently, there no comprehensive overview regulatory role IFN-I distinctive pathways as well diseases. This review aims to...
Rational regulation of active hydrogen (*H) behavior is crucial for advancing electrocatalytic nitrate reduction reaction (NO3RR) to ammonia (NH3), yet in‐depth understanding the *H generation, transfer, and utilization remains ambiguous, explorations dynamic optimization are urgently needed. Herein we engineer a Ni3N nanosheet array intimately decorated with Cu nanoclusters (NF/Ni3N‐Cu) remarkably boosted NO3RR. From comprehensive experimental theoretical investigations, moieties favors...
The healing of critical-sized bone defects (CSD) remains a challenge in orthopedic medicine. In recent years, scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional (3D) printing technology have lighted up treatment CSD due to elaborate microenvironments and support they may build. Here, we established magnesium oxide-reinforced 3D-printed biocomposite scaffold investigate effect magnesium-enriched 3D microenvironment on repairing. composite was prepared...
With the discovery of pivotal role macrophages in tissue regeneration through shaping immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extracellular matrix (dECM) has extensively used clinical treatment injury due its favorable biocompatibility and similarity native environment. However, most reported decellularization protocols may cause damage structure dECM, which undermines inherent advantages potential...
Abstract Secretin, though originally discovered as a gut-derived hormone, is recently found to be abundantly expressed in the ventromedial hypothalamus, from which central neural system controls satiety, energy metabolism, and bone homeostasis. However, functional significance of secretin hypothalamus remains unclear. Here we show that loss hypothalamus-derived leads osteopenia male female mice, primarily induced by diminished cAMP response element-binding protein phosphorylation...
Modern multislice computed tomography (CT) scanners produce isotropic CT images with a thickness of 0.6 mm. These offer detailed information lung cavities, which could be used for better surgical planning treating cancer. The major challenge developing system is the automatic segmentation lobes by identifying lobar fissures. This paper presents lobe algorithm that uses two-stage approach: (1) adaptive fissure sweeping to find regions and (2) wavelet transform identify locations curvatures...