A5100459389- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Metabolism and Genetic Disorders
- RNA Research and Splicing
- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Cancer, Hypoxia, and Metabolism
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Vibrio bacteria research studies
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Brucella: diagnosis, epidemiology, treatment
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Diet and metabolism studies
Harbin Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2024-2025
Jinshan Hospital of Fudan University
2025
Ludong University
2025
Education Department of Heilongjiang Province
2025
The First People's Hospital of Shunde
2019-2024
Southern Medical University
2016-2024
Xi'an Institute of Optics and Precision Mechanics
2024
Second Hospital of Shandong University
2024
Zhejiang University
2019-2024
Salmonella infection is a major public health concern worldwide, has contributed to an increased economic burden on the systems. Non-typhoidal (NTS) common cause of bacterial enteritis in humans, causing 93.8 million cases gastroenteritis globally each year, with 155,000 deaths. Guangzhou city situated south China and sub-tropical climate, heat heavy rainfall helps spread NTS. However, no information NTS available humans Conghua District, largest administrative district Guangzhou. To...
To construct a nomogram combining CT varices vein evaluation and clinical laboratory tests for predicting the risk of esophageal gastric variceal bleeding (EGVB) in patients with noncirrhotic portal hypertension (NCPH). A total 315 NCPH non-EGVB EGVB were retrospectively enrolled randomly divided into training testing cohorts. Thirteen collateral vessels identified evaluated after system reconstruction. Multivariate binary logistic regression analysis was used to choose images predictors...
Previous study indicates that long noncoding RNA NORAD could serve as a competing endogenous to pancreatic cancer metastasis. However, its role in colorectal (CRC) needs be investigated. In the present study, we found expression of was significantly upregulated CRC tissues. Furthermore, positively related with metastasis and patients’ poor prognosis. Knockdown markedly inhibited cell proliferation, migration, invasion but induced apoptosis vitro. vivo experiments also indicated an inhibitory...
miRNAs are essential for self-renewal and differentiation of normal malignant stem cells by regulating the expression key cell regulatory genes. Here, we report evidence implicating miR100 in cancer stem-like (CSC). We found that levels relate to cellular state, with lowest displaying markers. Utilizing a tetracycline-inducible lentivirus elevate human cells, increasing decreased production breast CSCs. This effect was correlated an inhibition proliferation vitro mouse tumor xenografts due...
MicroRNAs miR-9-3 and miR-193a have recently been found to be hypermethylated in a variety of non-small cell lung cancer (NSCLC) cells primary human tumors. The objectives this study were investigate the role demethylation genes regulating proliferation apoptosis NSCLCs, decipher potential mechanisms underlying properties.MTT population doubling time by flow cytometry used assess proliferation. Enzyme-Linked Immunosorbent Assay caspase-3 activity assay employed evaluate apoptosis. Real-time...
Although many typical outer-membrane proteins (OMPs) have been well characterized, the biological functions of OMPs remain largely elusive. In this study, we successfully constructed 29 OMP knockout strains in pathogen Aeromonas hydrophila, which account for about 50% all predicted bacterial species. We then further validated antibiotics' susceptibility characteristics against 20 antimicrobial reagents these mutants considering several phenotypes. Our results showed that a total 22 affected...
In recent years, the CTX-M-55 extended-spectrum β-lactamase (ESBL)-positive rate has gradually increased in clinic. To identify molecular epidemiology and characteristics of blaCTX-M-55-positive isolates, a total 374 non-repetitive ESBL-producing Escherichia coli strains were collected from patients two hospitals Guangzhou, 89 isolates selected by CTX-M-1-group PCR amplification confirmed DNA sequencing. Whole-genome sequencing was used to analyze resistance phenotype, plasmid types,...
Hunting for natural compounds that can modulate the structure of intestinal flora is a new hotspot colitis‐associated cancer (CAC) prevention or treatment. Alisol B 23-acetate (AB23A) tetracyclic triterpenoid found in Alismatis rhizoma which well known dietary herb. often used clinically to treat gastrointestinal diseases China. In this study, we investigated potential AB23A male mouse models azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced CAC. intervention alleviated body weight...
The insufficiency of compensatory angiogenesis in the heart patients with hypertension contributes to failure transition. hypoxia-inducible factor 1α–vascular endothelial growth (HIF1α–VEGF) signaling cascade controls responsive angiogenesis. One challenges reprograming insufficient is achieve a sustainable tissue exposure proangiogenic factors, such as HIF1α stabilization. In this study, we identified Rnd3, small Rho GTPase, participating regulation HIF1α–VEGF cascade. Rnd3 physically...
Long non-coding RNAs (lncRNAs) were confirmed to play important roles in human cancers. In this study, we explored the functional role of lncRNA double homeobox A pseudogene 8 (DUXAP8) non-small-cell lung cancer (NSCLC).Real-time quantitative PCR (RT-qPCR) was used detect DUXAP8 and microRNA-409-3p (miR-409-3p) expression. CCK-8, cell colony formation assay, Transwell migration assay performed measure growth migration, respectively. The expression relative proteins detected by Western blot....
is identified as the key oncogenic component of miR-17-92 cluster.When we explored functions dysregulated miR-19 in lung cancer, microarray-based data unexpectedly demonstrated that some immune and inflammatory response genes (i.e., IL32, IFI6 IFIT1) were generally down-regulated by overexpression A549 cells, which prompted us to fully investigate whether family miR-19a miR-19b-1) was implicated regulating expression cancer cells.In present study, observed or miR-19b-1 miRNA mimics A549,...
Abstract Background Gestational diabetes mellitus (GDM) is the most common medical complication associated with pregnancy, which may impose risks on both mother and fetus. Micro RNAs (miRNAs) long noncoding (lncRNAs) are implied as vital regulators in GDM. A recent paper revealed dysregulation of miR-33a-5p placental tissues GDM patients. However, biological function remains elusive. This study focused exploring underlying mechanisms Methods 12 pregnancies healthy were enrolled study. INS-1...
Exosomes mediate the interaction between cancer cells and their microenvironment, play a key role in tumor development. Although exosomes can package lncRNAs to extracellular communication, of exosomal lncRNA AY927529 prostate (PCa) remains unclear. were extracted from normal human prostatic epithelial cell lines (BPH-1 RWPE-1) PCa (VCaP LNCaP, DU145, PC3) by ultrahigh speed centrifugation. Results Western blot indicated that Alix, HSC70 TSGl01 protein levels upregulated derived cells....
p53-binding protein-1 ( 53BP1 ) plays a critical role in cell cycle checkpoint and DNA repair activities. Recently, was recognized as potential tumor suppressor gene. In this study, we investigated its function breast cancer. clinical samples, observed lower level of expression the cancer lesions than matched non-tumor tissues. Furthermore, showed gradual decrease during progression from precancerous to lesion. Ectopic can significantly inhibit proliferation curb invasiveness lines, whereas...
The aim of this study was to identify critical gene pathways that are associated with lung cancer metastasis the brain.The RNA-Seq approach used establish expression profiles a primary cancer, adjacent benign tissue, and metastatic brain tumor from single patient. these three types tissues were compared define differentially expressed genes, followed by serial-cluster analysis, ontology pathway knowledge-driven network analysis. Reverse transcription-polymerase chain reaction (RT-PCR)...
Klebsiella pneumoniae is important human and animal pathogen that causes a wide spectrum of infections. In this study, isolates from cattle nasal swabs samples were identified by 16S rRNA, to evaluate the antimicrobial susceptibility, virulence gene carrying levels, multilocus sequence typing K. isolates. 33 isolated in 213 samples, which 12 hypervirulent strains. Extended Spectrum Beta-Lactamases genes found 93.4% Of which, TEM was most prevalent (93.4%), followed CTX-M SHV 57.6% 39.4%,...
This paper aims to explore the relationship of retinal neuron apoptosis and manganese superoxidase dismutase (MnSOD) at early phase diabetic retinopathy. Sprague-Dawley rats were grouped into normal controls diabetics. Data collected after 4, 8, 12 weeks (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>12</mml:mn></mml:math>). The pathological changes ultrastructure retina, rate neurons by TdT-mediated dUTP nick end label (TUNEL),...