A5100779101- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Laser-induced spectroscopy and plasma
- Advanced Photocatalysis Techniques
- MicroRNA in disease regulation
- RNA modifications and cancer
- Bone Metabolism and Diseases
- Gene expression and cancer classification
- Analytical chemistry methods development
- Machine Learning in Bioinformatics
- Immune cells in cancer
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Laser Applications in Dentistry and Medicine
- Microfluidic and Capillary Electrophoresis Applications
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Catalytic Processes in Materials Science
- interferon and immune responses
- Bone Tissue Engineering Materials
- Advanced Sensor and Energy Harvesting Materials
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Magnetic Properties of Alloys
Fudan University
2023-2025
Capital Medical University
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
University of Toronto
2024-2025
Tongji University
2025
University of Electronic Science and Technology of China
2025
Capital University
2025
Jilin University
2020-2024
First Affiliated Hospital of Zhengzhou University
2024
Beijing Friendship Hospital
2022-2024
Abstract C 18 H 17 BrFN 5 O 2 , monoclinic, P 1 / c (no. 14), a = 19.3571(8) Å, b 13.4295(12) 7.3036(5) β 93.372(5)°, V 1895.3(2) Å 3 Z 4, R gt ( F ) 0.0407, wR ref 0.0939, T 293(2) K.
We present a facile two-stage UV/UV activation method for the polymerization of off-stoichiometry thiol-ene-epoxy, OSTE+, networks. show that handling and processing these epoxy-based resins is made easier by introducing material with controlled curing technique based on two steps, where first step offers excellent capabilities, second yields polymer suitable end-properties. investigate sequential thiol-ene thiol-epoxy reactions during steps studying mechanical properties, functional group...
Abstract Aspirin (acetylsalicylic acid, ASA) has been shown to improve bone marrow mesenchymal stem cell-based calvarial regeneration by promoting osteogenesis and inhibiting osteoclastogenesis. However, it remains unknown whether aspirin influences other immune cells during formation. In the present study, we investigated ASA treatment influenced macrophage activation LPS inducement. We found that could downregulate expressions of iNOS TNF-α both in mouse peritoneum macrophages RAW264.7...
Abstract Background Aspirin has been demonstrated to promote osteoblast-mediated bone formation and inhibit osteoclast (OC)-mediated resorption. However, it remains unclear whether aspirin influences other immune cells during Dendritic (DCs), the most potent antigen-presenting cells, can also transdifferentiate into active OCs in presence of receptor activator nuclear factor-κB ligand (RANKL) macrophage colony-stimulating factor (M-CSF). The effects on DC-derived (DDOCs) were investigated...
Delayed wound healing in diabetes is a global challenge, and the development of related drugs clinical problem to be solved. In this study, purpurolide C (PC), small-molecule secondary metabolite endophytic fungus Penicillium purpurogenum, was found promote diabetic healing. To investigate key regulation targets PC, vitro RNA-seq, molecular docking calculations, TLR4-MD2 dimerization SDS-PAGE detection, surface plasmon resonance (SPR) were performed, indicating that PC inhibited inflammatory...
The transforming growth factor-β (TGF-β) superfamily of ligands signals along two intracellular pathways, Smad2/3-mediated TGF-β/activin pathway and Smad1/5/8-mediated bone morphogenetic protein pathway. C terminus Hsc70-interacting (CHIP) serves as an E3 ubiquitin ligase to mediate the degradation Smad proteins many other signaling proteins. However, molecular mechanism for CHIP-mediated down-regulation TGF-β remains unclear. Here we show that extreme C-terminal sequence Smad1 plays...
Critical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying fate ligament stem cells could be beneficial for application regeneration. Nitric oxide (NO) regulates many biological processes developing embryos and adult cells. The present study was designed to investigate effects NO on function human (PDLSCs) as well elucidate molecular mechanisms. Immunofluorescent staining flow cytometry were used cell...
Benzo(a)pyrene [B(a)P], a ubiquitous environmental pollutant, causes lung inflammatory damage. Pyroptosis，a new inflammation-dependent programmed cell death, happened when pyroptosis-related GSDMD is activated mediated by NLRP3 inflammasome. microRNA-223 (miRNA-223) involved in diseases regulating NLRP3. However, whether regulate inflammasome through miR-223 B(a)P induced injury remain unknown. In this study, alveolar epithelial cells (A549) were stimulated with 0, 2, 4, 8 μM for 12 h or 24...
Sonodynamic therapy (SDT) is a novel therapeutic modality that effective for the noninvasive treatment of dermatological diseases. As ubiquitous large class sonosensitizers, however, porphyrins suffer from poor skin permeability and inefficient generation reactive oxygen species. Herein, different-sized porphyrinic metal–organic frameworks (MOFs), PCN-224 (90, 125, 200 nm), were developed via coordination tetra-kis(4-carboxyphenyl) porphyrin (TCPP) metal zirconium to enhance local delivery...
Implant therapy is a well-established clinical treatment, and porous implants are reported to be advantageous, which needs confirmed in vivo. In this study, we designed fabricated titanium with the same shape but different porosities (20 %, 30 40 50 respectively), produce elastic moduli based on results of finite element analysis (FEA). These devices were implanted into mandibular alveolar bone miniature swine, their survival rates, osseointegration, marginal loss evaluated one, three, six...