A5003431856- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Inflammasome and immune disorders
- Amino Acid Enzymes and Metabolism
- Cardiovascular Disease and Adiposity
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- S100 Proteins and Annexins
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and biosynthesis
Dana-Farber Cancer Institute
2018-2025
Harvard University
2018-2025
Trinity College Dublin
2012-2018
GlaxoSmithKline (United Kingdom)
2017
Abstract Age and sex are major risk factors in Alzheimer’s disease (AD) with a higher incidence of the females. Neuroinflammation, which is hallmark AD, contributes to pathogenesis inexorably linked inappropriate microglial activation neurodegeneration. We investigated sex-related differences microglia APP/PS1 mice post-mortem tissue from AD patients. Changes genes that indicative were preferentially increased cells female males females morphological, metabolically functionally distinct....
Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis. However, human protective against type 2 diabetes, independent of weight. The mechanism underlying this dissociation remains unclear. Here, we report impaired mitochondrial catabolism branched-chain amino acids (BCAAs) in BAT, by deleting BCAA carriers (MBCs), caused...
Obesity is one of the leading preventable causes cancer; however, little known about effects obesity on anti-tumor immunity. Here, we investigated CD8 T cells in mouse models and patients with endometrial cancer. Our findings revealed that cell infiltration suppressed obesity, which was associated a decrease chemokine production. Tumor-resident were also functionally obese mice, suppression amino acid metabolism. Similarly, found high BMI negatively correlated human cancer weight loss...
Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific metabolites that function as signaling molecules. Several Krebs cycles, or Krebs-cycle-derived metabolites, including succinate, α-ketoglutarate, and itaconate, have recently been shown to modulate macrophage function. The accumulation 2-hydroxyglutarate (2HG) has well documented in transformed cells more play a role T cell dendritic Here we...