A5048136889- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Transportation Planning and Optimization
- Traffic control and management
- Neuroscience and Neuropharmacology Research
- Traffic Prediction and Management Techniques
- Sleep and related disorders
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Transcranial Magnetic Stimulation Studies
- Blind Source Separation Techniques
- Vehicle Routing Optimization Methods
- Memory and Neural Mechanisms
- Gaze Tracking and Assistive Technology
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Metaheuristic Optimization Algorithms Research
- Advanced Neuroimaging Techniques and Applications
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
Beijing Luhe Hospital Affiliated to Capital Medical University
2024-2025
Chengdu Women's and Children's Central Hospital
2025
Chengdu Medical College
2025
Shanghai Clinical Research Center
2025
Harbin Medical University
2025
Inner Mongolia Normal University
2025
Southern University of Science and Technology
2021-2024
Jinan University
2021-2024
Massachusetts General Hospital
2019-2024
Second Hospital of Shandong University
2024
Abstract Background The role of physical exercise in the prevention Alzheimer’s disease (AD) has been widely studied. Microglia play an important AD. Triggering receptor expressed myeloid cells 2 (TREM2) is on microglia and known to mediate microglial metabolic activity brain glucose metabolism. However, relationship between metabolism during running APP/PS1 mice remains unclear. Methods Ten-month-old male wild-type were randomly divided into sedentary groups or (AD_Sed, WT_Sed, AD_Run...
Abstract Humans and animals lacking orexin neurons exhibit daytime sleepiness, sleep attacks, state instability. While the circuit basis by which contribute to consolidated wakefulness remains unclear, existing models posit that provide their wake-stabilizing influence exerting excitatory tone on other brain arousal nodes. Here we show using in vivo optogenetics, vitro optogenetic-based mapping, single-cell transcriptomics also maintenance through indirect inhibition of sleep-promoting...
Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving period impaired blood supply to the brain, followed by restoration cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage complex pathological process with an unclear physiological mechanism, more attention currently focused on neuroinflammatory response origin, anti-inflammatory appears be potential therapeutic strategy following stroke. QiShenYiQi (QSYQ),...
Growing evidence links impairment of brain functions in Alzheimer's disease (AD) with disruptions functional connectivity. However, whether the AD shows similar changes from a dynamic or cross-frequency view remains poorly explored. This paper provides an effective framework to investigate properties multiplex networks considering inter-frequency and temporal dynamics. Using resting-state EEG signals, two types were reconstructed separately network interactions between different frequency...
Alzheimer's disease is a neurodegenerative in old age, early diagnosis will help to delay the progression of disease. Presently, features brain functional diseases can be obtained with EEG analysis, but relationship between characteristics and has not been clearly clarified. In this work, we hypothesize that there exist default variables (latent factors) across subjects processes, decoding latent factor from activity contributes study cognitive impairment. To end, work proposes extract by...
The ant colony algorithm has been successfully used to solve discrete problems. However, its nature restricts applications the continuous domains. In this paper, we introduce two methods of ACO for solving first method references thought in space and need divide into several regions pheromone is assigned on each region discrete, ants depend construct path find solution finally. Compared with method, second one which distribution definition domain simulated normal essential difference one....
Epidemiological, cross-sectional, and prospective studies have suggested that insomnia, Alzheimer's disease (AD) depression are mutually interacting conditions frequently co-occur. The monoamine amino acid neurotransmitter systems in central nervous system were involved the examination of neurobiological processes this symptom complex. However, few reported systematic contrastive discussion different neurotransmitters (NTs) changing these neurological diseases. Thus, it is necessary to...
Background Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used as a treatment modality for chronic insomnia disorder (CID). However, our understanding of the mechanisms underlying efficacy rTMS is limited. Objective This study aimed to investigate rTMS-induced alterations in resting-state functional connectivity and find potential biomarkers predicting tracking clinical outcomes after rTMS. Methods Thirty-seven patients with CID received 10-session low frequency...
In this paper, we propose a novel method based on fuzzy learning and complex network for identification of Alzheimer's disease (AD) with electroencephalograph (EEG) signals. Weighted visibility graph (WVG) algorithm is first applied to transform each channel EEG into its topological parameters were further extracted. Statistical analysis indicates that AD normal subjects show significant difference in the structure WVG thus can be used identify disease. Taking as input features,...
Purpose: Our study is aimed at exploring the association between peripheral artery disease (PAD) and metabolic syndrome (MetS) across different age gender groups among patients with Type 2 diabetes mellitus (T2DM). Patients Methods: A total of 3638 T2DM were enrolled in study, including 281 PAD 3357 without PAD. Demographic data anthropometric measurements, such as height, weight, waist circumference, collected. Laboratory tests ankle-brachial index (ABI) assessment also conducted. Multiple...
This paper presents a microscopic traffic simulation approach to the capacity impact analysis of weaving sections caused by installation exclusive bus lanes (XBLs) on urban expressways. Three typical configurations XBL in Beijing are identified, including median lane with off-on-ramp, curbside on-off-ramp, and off-on-ramp. Then, section length, headway, mainline volume, as well off-ramp on-ramp volumes for general considered parameters designing scenarios. Finally, is executed, which...
Abstract Sleep spindles, defining oscillations of non‐rapid eye movement stage 2 sleep (N2), mediate memory consolidation. Spindle density (spindles/minute) is a stable, heritable feature the electroencephalogram. In schizophrenia, reduced spindle correlates with impaired sleep‐dependent consolidation and promising treatment target. Measuring spindles also important for basic studies memory. However, overnight are expensive, time consuming require considerable infrastructure. Here we...
Abstract Aims Neuroinflammation is one of the most important processes in pathogenesis Parkinson's disease (PD). Sensory disturbances are common patients with PD, but underlying pathophysiological mechanisms remain unknown. This study aimed to characterize activation Schwann cells (SCs) and increase expression inflammatory cytokines IL‐1β, IL‐6, TNF‐α sural nerve further explore whether peripheral inflammation cause PD sensory disturbances. Methods A total 14 (including 5 9 without...