A5030785799- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Measurement and Metrology Techniques
- Photonic and Optical Devices
- Ginkgo biloba and Cashew Applications
- COVID-19 Clinical Research Studies
- Force Microscopy Techniques and Applications
- Wastewater Treatment and Nitrogen Removal
- Optical measurement and interference techniques
- Pharmacological Effects of Natural Compounds
- Signaling Pathways in Disease
- Immune Response and Inflammation
- Plant-based Medicinal Research
- Autophagy in Disease and Therapy
- Advanced Sensor Technologies Research
- Near-Field Optical Microscopy
- Andrographolide Research and Applications
- Scientific Measurement and Uncertainty Evaluation
- Optical Coatings and Gratings
- Semiconductor Lasers and Optical Devices
- Natural Compounds in Disease Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Calcium signaling and nucleotide metabolism
- Mass Spectrometry Techniques and Applications
Tongji University
2023-2025
Tianjin University of Traditional Chinese Medicine
2019-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Shanghai Jiao Tong University
2023
Tianjin International Joint Academy of Biomedicine
2019-2022
Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving period impaired blood supply to the brain, followed by restoration cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage complex pathological process with an unclear physiological mechanism, more attention currently focused on neuroinflammatory response origin, anti-inflammatory appears be potential therapeutic strategy following stroke. QiShenYiQi (QSYQ),...
Shuxuening injection (SXNI), one of the pharmaceutical preparations Ginkgo biloba extract, has significant effects on both ischemic stroke and heart diseases from bench to bedside. Its major active ingredients are ginkgo flavonol glycosides (GFGs) ginkgolides (GGs). We have previously reported that SXNI as a whole protected brain heart, but their contribution therapeutic remain unclear. Therefore, we combined experimental network analysis approach further explore specific underlying...
Sepsis-induced myocardial dysfunction is a major contributor to the poor outcomes of septic shock. As an add-on with conventional sepsis management for over 15 years, effect Xuebijing injection (XBJ) on sepsis-induced was not well understood. The material basis in managing infections and infection-related complications remains be defined. A murine cecal ligation puncture (CLP) model cardiomyocytes vitro culture were adopted study influence XBJ infection-induced cardiac dysfunction....
Heart failure (HF) is a cardiovascular disease with high morbidity and mortality. Guanxinning injection (GXNI) clinically used for the treatment of coronary heart disease, but its therapeutic efficacy potential mechanism HF are poorly understood. This study aimed to evaluate GXNI on HF, special focus role in myocardial remodeling. 3D cardiac organoids transverse aortic constriction (TAC) mouse models were established utilized. function pathology evaluated by echocardiography, hemodynamic...
A mild ischemic stroke may cause both debilitating locomotor and cognitive decline, for which the mechanism is not fully understood, no therapies are currently available. In this study, a nonfatal model was constructed in mice by modified middle cerebral artery occlusion (MCAO) procedure, allowing an extended recovery period up to 28 days. The MCAO successfully mimicked phenotypes of phase post-stroke, including motor deficiencies, were effectively improved after Shuxuening injection (SXNI)...
Abstract Nanoscale measurement is an essential task of nanomanufacturing, and traceability a fundamental aspect nanoscale measurement. High-precision instruments (e.g. atomic force microscopes (AFM) scanning electron (SEM)) need to be calibrated by traceable standards ensure their accuracy reliability. However, due the suboptimal accuracy, uniformity, consistency existing standards, they metrological primary length physical wavelength standards) before use. This results in long chain that...
Post-stroke neural damage is a serious health concern which does not yet have an effective treatment. We shown previously that Shuxuening injection (SXNI), Ginkgo biloba extract-based natural medicine, protects brain after acute ischemic stroke, but its efficacy for post-stroke recovery known. This study was to investigate whether SXNI can improve the prognosis of stroke at subacute phase. Mice with cerebral ischemia-reperfusion injury (CIRI) were established by middle artery occlusion...
Stroke often results in neurological and neuropsychiatric sequela. Exosomes derived from brain endothelial cells (EC-Exo) protect neurons hypoxic injury. However, the biological role of exosomes apoptosis synaptic plasticity remains unclear. This research aimed to assess whether cerebral microvascular inhibit promote remodeling through exosome-mediated cell-cell interaction after ischemic attack. The effects EC-Exo on primary neuronal synapses oxyglucose deprivation reoxygenation (OGD/R)...
QiShen YiQi (QSYQ) dropping pill, a component-based Chinese medicine consisting of benefiting Qi (YQ) and activating blood (HX) components, has been reported to exert beneficial effect on cerebral ischemia-induced stroke. However, its efficacy pharmacological mechanism acute thromboembolic stroke is not clear.This study explore the preventative QSYQ YQ/HX components formation platelet-leukocyte aggregation (PLA) in stroke.In vivo model FeCl3-induced carotid arterial occlusion models were...
Precise positioning measurement plays an important role in today advanced manufacturing industry, and length traceability chain has been optimizing enriching to fulfill the developing various precise requirement. In this paper, we propose a new based on chromium atom transition frequency, which is combining utilization of fundamental physical constant accuracy grating interferometer environmental robustness. The selftraceable pitch standard, angle standard are promising improve accuracy,...
Effective therapies for stroke are still limited due to its complex pathological manifestations. QiShenYiQi (QSYQ), a component-based Chinese medicine capable of reducing organ injury caused by ischemia/reperfusion, may offer an alternative option treatment and post-stroke recovery. Recently, we reported beneficial effect QSYQ acute via modulation the neuroinflammatory response. However, if plays role in subacute remains unknown. The pharmacological action was investigated experimental rats...
Hypertension is a leading risk factor for developing kidney disease. Current single-target antihypertensive drugs are not effective hypertensive nephropathy, in part due to its less understood mechanism of pathogenesis. We recently showed that QiShenYiQi (QSYQ), component-based cardiovascular Chinese medicine, also ischemic stroke. Given the important role brain-heart-kidney axis blood pressure control, we hypothesized QSYQ may contribute regulation and protection Dahl salt-sensitive...
Abstract To overcome the autophagy compromised mechanism of protective cellular processes by “eating”/“digesting” damaged organelles or potentially toxic materials with autolysosomes in tumor cells, lysosomal impairment can be utilized as a traditional dysfunction route for therapy; however, this conventional one‐way approach is always limited therapeutic efficacy. Herein, an innovative pharmacological strategy that excessively provoke via endoplasmic reticulum (ER) stress implemented along...
Guanxinning Injection (GXNI) is used clinically to treat cardiac injury, but its active components and mode of action remains unclear. Therefore, a myocardial ischemia/reperfusion injury (MIRI) model-based integrated strategy including function evaluation, RNA-seq analysis, molecular docking, cellular thermal shift assay (CETSA) was employed elucidate the effect mechanism GXNI main ingredient on injury. These results revealed that significantly improved dysfunction in I/R mice. analysis...
Chinese guideline has proven effective in the fight against coronavirus disease 2019 (COVID-19) during global spread of epidemic. Traditional medicine (TCM) is widely recognized for its effectiveness alleviating symptoms, inhibiting progress, reducing mortality, and improving cure rate patients with COVID-19. During pandemic, “three medicines three formulas” (TMTFs) stood out from hundreds others registered clinical studies, which became highly recommended as TCM COVID-19 treatment. The...