A5101547727- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Sperm and Testicular Function
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Neurological Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Alzheimer's disease research and treatments
- Reproductive Biology and Fertility
- Xenotransplantation and immune response
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Axon Guidance and Neuronal Signaling
- Tuberous Sclerosis Complex Research
- Zebrafish Biomedical Research Applications
- Histiocytic Disorders and Treatments
- Antioxidants, Aging, Portulaca oleracea
- Breast Cancer Treatment Studies
- Beetle Biology and Toxicology Studies
- Gastric Cancer Management and Outcomes
- Erythropoietin and Anemia Treatment
Dalian Medical University
2025
First Affiliated Hospital of Dalian Medical University
2025
China National Environmental Monitoring Center
2025
Ministry of Ecology and Environment
2025
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2018-2024
Shaanxi University of Science and Technology
2024
Suzhou Municipal Hospital
2018-2022
Nanjing Maternity and Child Health Care Hospital
2016-2022
Hong Kong Baptist University
2022
Stroke increases neurogenesis. The authors investigated whether neural stem cells or progenitor in the adult subventricular zone (SVZ) of rats contribute to stroke-induced increase After induction stroke rats, numbers immunoreactive doublecortin, a marker for immature neurons, increased ipsilateral SVZ and striatum. Infusion an antimitotic agent (cytosine-β-D-arabiofuranoside, Ara-C) onto cortex eliminated more than 98% actively proliferating doublecortin-positive However, rapidly...
Malignant gliomas are the most common primary brain tumors, and associated with frequent resistance to therapy as well poor prognosis. Here we demonstrate that nuclear receptor tailless (Tlx), which in adult is expressed exclusively astrocyte-like B cells of subventricular zone, acts a key regulator neural stem cell (NSC) expansion tumor initiation from NSCs. Overexpression Tlx antagonizes age-dependent exhaustion NSCs mice leads migration stem/progenitor their natural niche. The increase...
To review the characteristics of newborn screening congenital hypothyroidism (CH), we reviewed data, including levels blood spot thyroid-stimulating hormone (TSH), and serum TSH free thyroxine (FT4), all infants who accepted program during last 14 years. In total, 437,342 underwent CH 192 were diagnosed with incidence was 1:2278. The positive rate initial 0.96%, predictive value 4.8%. We also designed a target sequencing panel 13 causative genes: DUOX2, TG, TPO, TSHR, TTF1, TTF2, PAX8,...
BackgroundTumor mutations and tumor microenvironment are associated with resistance to cancer immunotherapies. However, peripheral T cell in effective anti-programmed death 1 (PD-1) antibody treatment is poorly understood.MethodsMass spectrometry conventional flow cytometry were used investigate blood cells isolated from patients. Furthermore, melanoma mouse model was performed assess the role of CXCR3 signaling anti-PD-1 treatment.FindingsWe revealed a marked increase percentage CXCR3+...
Natural plant products occupy a very important position in the area of cancer chemotherapy. Many triterpenoid saponins have been proved as potential agents for chemoprevention and therapy breast cancer. α-hederin, monodesmosidic saponin distributed Hedera or Nigella species, displays many biological activities. It is increasingly investigated its promising anticancer since it has shown to cytotoxicity against several types cells. However, studies α-hederin on are limited, most which focus...
ABSTRACT Miniature pigs have advantages over rodents in modeling atherosclerosis because their cardiovascular system and physiology are similar to that of humans. Apolipoprotein E (ApoE) deficiency has long been implicated disease To establish an improved large animal model familial hypercholesterolemia atherosclerosis, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) was used disrupt ApoE gene Bama miniature pigs. Biallelic-modified...
Proneuronal basic helix–loop–helix (bHLH) transcription factor, neurogenin 1 (Ngn1), regulates neuronal differentiation during development of the cerebral cortex. Akt mediates proneuronal bHLH protein function to promote differentiation. Here, we show that recombinant human erythropoietin (rhEPO) significantly increased activity and Ngn1 mRNA levels in neural progenitor cells derived from subventricular zone (SVZ) adult rat, which was coincident with increases cell proliferation,...
Cerebral stroke induces proliferation of subventricular zone (SVZ) neural progenitor cells in adult rodent brain. Tumor necrosis factor-α-converting enzyme (TACE) proteolysis sheds the nonamyloidogenic soluble ectodomain amyloid precursor protein (APP) and is a convertase for tumor factor-α (TNFα). The resulting peptides APP TNFα are mitogenic SVZ. Therefore, we hypothesized role TACE stroke-induced neurogenesis. Using laser-capture microdissection, found transcription was increased SVZ...
The objective of this study was to assess the feasibility detecting variation sentinel lymphatic channels (SLCs) and lymph nodes (SLNs) in breast cancer patients using contrast-enhanced ultrasound (CEUS). A total 46 were prospectively recruited study. All participants received intradermal peritumoral injection microbubbles as contrast agent, SLCs SLNs assessed preoperatively. Blue dye injected subareolarly peritumorally during surgery. detected by CEUS blue sent pathology laboratory for...
Complement protein C3 is the pivotal component of complement system. Previous studies have demonstrated that has implications in various human diseases and exerts profound functions under certain conditions. However, delineation pathological physiological roles been hampered by insufficiency suitable animal models. In present study, we applied clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system to target gene porcine fetal fibroblasts. Our results...
Various types of PTMs play important roles in the regulation sperm proteins. However, most large‐scale proteomic studies only focused on a single type modification due to limitation enrichment methods. To investigate complex composition modified proteins, we constructed human proteome 2.0 that integrated lysine acetylated, phosphorylated, N‐linked glycosylated, and protein N‐terminal acetylated proteins from previously published datasets. A total 6069 sites 2132 were annotated. Functional...
<title>Abstract</title> <bold>OBJECTIVE: </bold>To investigate the effects of different lifestyle habits on occurrence types colorectal adenomas and their initial stages cancer. <bold>Methods: </bold>276 patients with tubular adenomas, 67 serrated 70 high-grade intraepithelial neoplasia, 194 patients(control group ) underwent colonoscopy were confirmed by pathology in First Affiliated Hospital Dalian Medical University during June 2023-December 2023. Lifestyle habits’ information was...
Background: Tumor‐associated neutrophils (TANs), a major immune cell type in the tumor microenvironment (TME), are associated with antitumor or pro‐tumor phenotypes. A wealth of evidence evidences demonstrated that content TANs has been implicated pathogenesis cancer and may be ideal targets for therapy. In this study, we identified TANs‐related genes to construct prognostic model evaluated its potential as biomarker predicting prognosis immunotherapeutic response colorectal carcinoma (CRC)....
Global transcriptional silencing in fully grown oocytes is a critical event during mammalian oogenesis. However, how this regulated remains elusive. Here, we provide evidence that poly(rC)-binding protein 1 (PCBP1), found by us previously to be present metaphase II (MII) mouse oocytes, participates maintenance of the transcriptionally silent state oocytes. Knocking down Pcbp1 microinjection its specific siRNAs into germinal vesicle (GV) resulted remarkable changes their state, including...
Abstract Background Esophageal cancer is the sixth leading cause of cancer-related mortality worldwide, which partially due to limited progress therapy. Apatinib, an inhibitor VEGFR2, has a promising antitumor effect on malignancies. However, underlying mechanism its esophageal remains poorly understood. Materials and methods Eighteen pairs frozen their para-cancer samples 25 paraffin specimens from advanced patients treated with cisplatin-based regimen were collected. The effects apatinib...
Background Oligozoospermia is one of the severe forms idiopathic male infertility. However, its pathology largely unknown, and few genetic factors have been defined. Our previous genome-wide association study (GWAS) has identified four risk loci for non-obstructive azoospermia (NOA). Objective To investigate potentially functional variants (including not only common variants, but also less-common rare variants) these on spermatogenic impairment, especially oligozoospermia. Design, Setting,...
// Liang Shi 1,* , Tian-Song Xia Xiao-Long Wei 3,* Wenbin Zhou 1 Jinqiu Xue Lin Cheng Peipei Lou Chunlian Li Ying Wang Ji-Fu 2 Qiang Ding Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China Research Division of Clinical Pharmacology, 3 Department Pathology, Cancer Shantou University College, Shantou, * These authors have contributed equally to this work Correspondence to: Ding, email: Wei, Keywords : estrogen receptor, RNPC1, mRNA...
Abstract Background To investigate graft survival after full‐thickness corneal xenotransplantation from α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs expressing a human complement regulatory protein ( GTKO / CD 46 pigs) in rhesus monkeys. Methods Rhesus monkeys (n=10) were transplanted with corneas wild‐type WT ; n=4) and (n=4) or (n=2). All recipient received post‐transplant subconjunctival injections of betamethasone. Corneal grafts evaluated by slit‐lamp. Histopathology,...
Dietary meats play a crucial role in human health. The objective of this survey was to determine the fatty acid content and omega-6/omega-3 polyunsaturated acids (n-6/n-3 PUFA) ratio fresh red meat (beef pork) from four cities (Shanghai, Nanjing, Yinchuan Hohhot) China. results showed that n-6/n-3 PUFA all samples ranged 6 23. total n-6 concentrations 290.54 mg/100 g beef Nanjing 1601.48 pork Hohhot, whereas n-3 46.34 96.03 Nanjing. indicated regions is unbalanced much higher than (< 5:1)...