A5101996964- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Virus-based gene therapy research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Cancer, Stress, Anesthesia, and Immune Response
- Trace Elements in Health
- Epilepsy research and treatment
- Medical Research and Treatments
- Inflammatory mediators and NSAID effects
- Neonatal Respiratory Health Research
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
- Microbial Natural Products and Biosynthesis
- RNA modifications and cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Gut microbiota and health
- Enhanced Recovery After Surgery
- Nausea and vomiting management
- Neurological Disease Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Studies on Chitinases and Chitosanases
Nanjing University of Chinese Medicine
2007-2025
Third Affiliated Hospital of Zhengzhou University
2013-2024
Stanford University
2021-2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2024
Zhejiang University
2019-2024
Chongqing Medical and Pharmaceutical College
2019-2023
Children's Hospital of Zhejiang University
2016-2023
North China Institute of Science and Technology
2022
East China University of Science and Technology
2016-2022
Shanghai Changzheng Hospital
2022
To understand the dynamic interplay between human microbiome and host during health disease, we analyzed microbial composition, temporal dynamics, associations with multi-omics, immune, clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that stability individuality are body-site specific heavily influenced by host. The stool oral more stable than skin nasal microbiomes, possibly due to their interaction environment. identify individual-specific...
Chloropupukeananin (1), the first pupukeanane chloride with highly functionalized tricyclo-[4.3.1.03,7]-decane skeleton and its possible biosynthetic precursors iso-A82775C (2) pestheic acid (3), have been isolated from plant endophyte Pestalotiopsis fici. The structure of 1 was determined by NMR spectroscopy X-ray crystallography. Biogenetically, could be derived Diels−Alder adduct 2 3.
To review the characteristics of newborn screening congenital hypothyroidism (CH), we reviewed data, including levels blood spot thyroid-stimulating hormone (TSH), and serum TSH free thyroxine (FT4), all infants who accepted program during last 14 years. In total, 437,342 underwent CH 192 were diagnosed with incidence was 1:2278. The positive rate initial 0.96%, predictive value 4.8%. We also designed a target sequencing panel 13 causative genes: DUOX2, TG, TPO, TSHR, TTF1, TTF2, PAX8,...
Five new asterric acid derivatives, ethyl asterrate (3), n-butyl (4), and geomycins A−C (6−8), have been isolated from cultures of an isolate the Antarctic ascomycete fungus Geomyces sp. The structures these metabolites were elucidated by NMR spectroscopy. absolute configuration 8 was determined application CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas showed antimicrobial activities Gram-positive Gram-negative bacteria.
Metallothionein 1H (MT1H) expression level is downregulated in several kinds of tumors, including hepatocellular cancer (HCC). However, its biological functions and underlying mechanisms HCC largely unknown. The current study aimed to demonstrate the status, roles potential MT1H HCC. We investigated Cancer Genome Atlas (TCGA) dataset a panel 12 paired tumor/non-tumor tissues. In vitro, gain-of-function experiments were performed examine role on cell proliferation, invasion, migration. Using...
To identify the spectrum and prevalence of thirteen causative genes mutations in congenital hypothyroidism (CH) patients, we collected blood samples extracted genomic DNA 106 CH designed a customized targeted next-generation sequencing panel containing 13 CH-causing to detect mutations. A total 132 were identified 65.09% patients (69/106) on following nine genes: DUOX2, TG, TPO, TSHR, TTF1, TTF2, NKX2-5, PAX8 GNAS. 69.70% (92/132) related thyroid dyshormonogenesis genes, including DUOX2 (n =...
The role of inflammation response has been well documented in the development acute lung injury (ALI). However, little is known about functions miRNAs regulation ALI. aim this study was to explore effects ALI and elucidate biomolecular mechanisms responsible for these effects. expression profiles tissues from lipopolysaccharide (LPS)-induced mice model were analyzed using a microarray. It observed that microRNA-221-3p (miR-221) significantly increased mice. inhibition miR-221 attenuated...
Rationale: Linear nevus sebaceous syndrome (LNSS) is a rare neurocutaneous syndrome, characterized by sebaceous,central nervous system (CNS), ocular and skeletal abnormalities. The present study describes KRAS somatic mosaic mutation in case of LNSS with lymphatic malformations (LMs). Patient concerns: A 4-month-old female clinical diagnosis presented infantile spasms, mental retardation, skull dysplasia, abnormalities, congenital atrial septal defect, LMs. Diagnosis: Cervical...
The volatile compounds formed in slapped and crushed young leaves of Japanese pepper (Xanthoxylum piperitum DC.) were compared with those intact by using a dynamic headspace gas analysis combined GC-MS an on-line system, together the results sensory evaluation. indicated that factors influencing aroma note mainly constituent oxygenated monoterpenes C(6) quantity terpene hydrocarbons. To clarify formation mechanism for aroma, activities lipoxygenase beta-D-glucosidase investigated. revealed...
BACKGROUND:We aimed to explore the factors leading epidural-related maternal fever and influence of intrapartum on neonates. MATERIAL AND METHODS:A retrospective analysis was performed data from pregnant women who received epidural analgesia during labor. The primary aim determine labor incidence in women. secondary RESULTS:Logistic regression showed that premature rupture membranes (OR=2.008, 95% CI: 1.551–2.600), vaginal examination more than 6 times (OR=1.681, 1.286–2.197), long duration...
Abstract Background Infants suffer from a severe epileptic encephalopathy known as West syndrome (WS). Treatment with adrenocorticotropic hormone (ACTH) indicates the involvement of gut-brain axis in WS. Several pieces evidence show communication gut microbiota (GM) brain via hypothalamic–pituitary–adrenal (HPA axis) and blood cytokines. This study aimed at (1) determining GM diversity infants having WS (2) comparing results those healthy also patients before after ACTH therapy. Results In...