A5009238693- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Genomic variations and chromosomal abnormalities
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Transplantation: Methods and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Genomics and Rare Diseases
- Venous Thromboembolism Diagnosis and Management
- Consumer Attitudes and Food Labeling
- Hepatitis C virus research
- Xenotransplantation and immune response
- Genetics and Neurodevelopmental Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Coronary Interventions and Diagnostics
- Acute Ischemic Stroke Management
- HIV/AIDS drug development and treatment
- Acute Myocardial Infarction Research
University of Pennsylvania
2018-2024
California University of Pennsylvania
2023
Penn Center for AIDS Research
2023
Hospital of the University of Pennsylvania
2020-2021
Deciphering the impact of genetic variation on gene regulation is fundamental to understanding common, complex human diseases. Although histone modifications are important markers regulatory elements genome, any specific modification has not been assayed in more than a few individuals liver. As result, effects states liver poorly understood. Here, we generate most comprehensive genome-wide dataset two epigenetic marks, H3K4me3 and H3K27ac, annotate thousands putative We integrate these...
Abstract Background Loss-of-Function (LoF) variants in human genes are important due to their impact on clinical phenotypes and frequent occurrence the genomes of healthy individuals. The association LoF with complex diseases traits may lead discovery validation novel therapeutic targets. Current approaches predict high-confidence without identifying specific or number copies they affect. Moreover, there is a lack methods for detecting knockout caused by compound heterozygous (CH) variants....
BackgroundST-segment elevation myocardial infarction (STEMI) patients are treated with dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor. Clopidogrel is widely used in these several areas worldwide, such as Middle East, but associated to sub-optimal platelet inhibition up 1/3 of patients. We investigated CYP2C19 genotype-guided strategy select the optimal inhibitor.MethodsThis prospective randomized clinical trial included STEMI The standard-treatment group received...
Exclusive HCV therapy clinical trials with genotype 6 patients in high prevalence areas have been sparse. We analysed the safety and efficacy of two generic, pangenotypic NS5A/NS5B combination oral DAA regimens, primarily genotypes 3 6, a real-world setting: (a) daclatasvir/sofosbuvir (DCV/SOF) ± ribavirin (RBV) (b) Velpatasvir/sofosbuvir (VEL/SOF RBV). Between December 2015 November 2017, data from 522 were analysed, 311 whom treated DCV/SOF RBV for 12/24 weeks (genotype 3: n = 193, 6: 89)...
Abstract Background Diabetes mellitus is a chronic disease characterized by wide range of metabolic problems. The current study sought to assess nutritional habits Saudi patients with type 2 diabetes (T2D) and propose recommendations improve these patients’ dietary delay possible complications. Methods Over period three years, (2017–2019) 577 T2D attending the outpatient’s diabetic clinics at King Fahd Hospital University, Al Khobar, Arabia were invited participate in this study. Data intake...
Abstract Tacrolimus metabolism is heavily influenced by the CYP3A5 genotype, which varies widely among African Americans (AA). We aimed to assess performance of a published genotype‐informed tacrolimus dosing model in an independent set adult AA kidney transplant (KTx) recipients. genotypes were obtained for all KTx recipients (n = 232) from 2010 2019 who met inclusion criteria at single center Philadelphia, Pennsylvania, USA. Medical record data used calculate predicted clearance using...
Abstract Genetic matching between transplant donor and recipient pairs has traditionally focused on the human leukocyte antigen (HLA) regions of genome, but recent studies suggest that for non‐HLA may be important as well. We assess four genetic scores use in association analyses outcomes. These describe ancestry distance using identity‐by‐state, or incompatibility mismatch two genomes therefore reflect different underlying biological mechanisms genes to influence Our simulation show jointly...
ABSTRACT Background Recent advances in xenotransplantation living and decedent humans using pig xenografts have laid promising groundwork towards future emergency use first human trials. Major obstacles remain though, including a lack of knowledge the genetic incompatibilities between donors recipients which may led to harmful immune responses against xenograft or dysregulation normal physiology. In 2022 two heart were transplanted into brain-dead decedents with minimized immunosuppression...
ABSTRACT Deciphering the impact of genetic variation on gene regulation is fundamental to understanding common, complex human diseases. Although histone modifications are important markers regulatory regions genome, any specific modification has not been assayed in more than a few individuals liver. As result, impacts that direct states liver poorly understood. Here, we generate most comprehensive genome-wide dataset two epigenetic marks, H3K4me3 and H3K27ac, annotate thousands putative...
Abstract Background Diabetes mellitus is a chronic disease characterized by wide range of metabolic problems. The current study sought to assess nutritional habits Saudi subjects with type 2 diabetes (T2D), in order propose recommendation improve these patients' dietary and delay possible complications. Methods Over period three years, (2017–2019) 577 patients T2D attending the outpatient’s diabetic clinics at King Fahd Hospital University Al Khobar, Arabia were invited participate this...
Ischemic stroke represents a significant societal burden across the globe. Rare high penetrant monogenic variants and less pathogenic common single nucleotide polymorphisms (SNPs) have been described as being associated with risk of diseases. Genetic studies in Saudi Arabian patients offer greater opportunity to detect rare mutations enriched these consanguineous populations. We performed whole exome sequencing on 387 ischemic subjects from hospital networks up 20,230 controls Human Genome...
Background. Deceased donor and recipient predictors of posttransplant steatosis/steatohepatitis fibrosis are not well known. Our aim was to evaluate the prevalence assess steatosis, steatohepatitis, in liver transplantation recipients. Methods. Using immune tolerance network A-WISH multicenter study (NCT00135694), demographic clinical features were collected. Liver biopsies taken from at transplant, recipients per protocol for-cause (ie, abnormal transaminases rule out rejection) interpreted...
Abstract BACKGROUND AND AIMS The genetics of kidney function has been extensively studied, but since these analyses have done mostly in populations with normal or mildly impaired function, it is still unknown whether variants linked to also translate into genetic susceptibility for failure. primary aim this study was investigate the background METHOD We performed a meta-analysis failure genome-wide association studies, using transplant recipients as cases (n = 6942) and donors controls...
Abstract Motivation Loss-of-Function (LoF) variants in human genes are important due to their impact on clinical phenotypes and frequent occurrence the genomes of healthy individuals. Current approaches predict high-confidence LoF without identifying specific or number copies they affect. Moreover, there is a lack methods for detecting knockout caused by compound heterozygous (CH) variants. Results We have developed ToolKit (LoFTK), which allows efficient automated prediction from both...