A5018777857- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Medical Imaging Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Renal cell carcinoma treatment
- Renal and related cancers
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2020-2025
University of Wisconsin–Madison
2018-2021
Shanghai Cancer Institute
2020
State Key Laboratory of Oncogene and Related Genes
2020
Shanghai Sixth People's Hospital
2014-2019
Lanzhou Jiaotong University
2007
The interaction between radionuclides and nanomaterials could generate Cerenkov radiation (CR) for CR-induced photodynamic therapy (PDT) without requirement of external light excitation. However, the relatively weak CR leaves clinicians uncertain about benefits this new type PDT. Therefore, a novel strategy to amplify therapeutic effect PDT is imminently required overcome disadvantages traditional nanoparticulate such as tissue penetration limitation, dependence, low tumor accumulation...
Data from a large cohort of patients with pulmonary metastases differentiated thyroid cancer (DTC) were retrospectively analyzed.To assess the effect radioiodine therapy and investigate prognostic factors survival for metastasis secondary to DTC.A total 372 DTC treated (131)I entered study. According results whole-body scan (WBS), classified as (131)I-avid non-(131)I-avid. For lung metastases, treatment response was measured by three parameters: serum thyroglobulin (Tg) levels, chest...
Overexpression of CD47 is frequently observed in various types human malignancies, inhibiting myeloid-mediated elimination tumor cells and affecting the prognosis cancer patients. By mapping biomarker expression, immuno-positron emission tomography has been increasingly used for patient screening response monitoring. immunization alpacas with recombinant CD47, we prepared a CD47-targeting nanobody C2 developed [ 68 Ga]Ga-NOTA-C2, followed by an exploration diagnostic value CD47-expressing...
Abstract Accurately predicting and selecting patients who can benefit from targeted or immunotherapy is crucial for precision therapy. Trophoblast cell surface antigen 2 (Trop2) has been extensively investigated as a pan-cancer biomarker expressed in various tumours plays role tumorigenesis through multiple signalling pathways. Our laboratory successfully developed two 68 Ga-labelled nanobody tracers that rapidly specifically target Trop2. Of the tracers, [ Ga]Ga-NOTA-T4, demonstrated...
Background The programmed cell death protein-1 (PD-1)/programmed receptor ligand 1 (PD-L1) axis critically facilitates cancer cells’ immune evasion. Antibody therapeutics targeting the PD-1/PD-L1 have shown remarkable efficacy in various tumors. Immuno-positron emission tomography (ImmunoPET) imaging of PD-L1 expression may help reshape solid tumors’ immunotherapy landscape. Methods By immunizing an alpaca with recombinant human PD-L1, three clones v ariable domain h eavy chain eavy-chain...
Abstract Background Although immunotherapy has revolutionized treatment strategies for some types of cancers, most patients failed to respond or obtain long-term benefit. Tumor-infiltrating CD8 + T lymphocytes are closely related the outcome and prognosis patients. Therefore, noninvasive elucidation both systemic tumor-infiltrating is extraordinary significance during cancer immunotherapy. Herein, a panel 68 Ga-labeled Nanobodies were designed investigated track human cells in vivo through...
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally high kidney retention, limiting their therapeutic applications. Therefore, engineering strategies such as PEGylation incorporation of renal cleavable linkers can be adapted to improve pharmacokinetics...
For melanoma resistant to molecularly targeted therapy and immunotherapy, new treatment strategies are urgently needed. A theranostic pair may thus be of importance, where the diagnostic probe facilitates patient stratification therapeutic companion treats selected cases. this purpose, flow cytometry is used assess CD146 level in cells. Based on YY146, a CD146-specific monoclonal antibody, an imaging
Abstract Assessing programmed death ligand‐1 (PD‐L1) expression in non‐small cell lung cancer (NSCLC), particularly metastatic cases, remains challenging. In this study, surface plasmon resonance (SPR) analysis and [ 68 Ga]Ga‐DOTA‐WL12 micro‐PET/CT imaging are performed. PET/CT 18 F]FDG performed on a cohort of 20 patients with NSCLC. Semi‐quantitative assessments include SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG), target‐to‐background ratio (TBR). DOTA‐WL12 exhibits...
The diagnosis and surveillance of clear cell renal carcinoma (ccRCC) remains a clinical challenge. high specific expression the cluster differentiation 70 (CD70) in ccRCC makes it potential diagnostic therapeutic target.
Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients with non-131I and 131I-avid lung metastases are differentially expressed. These have to be further validated the role of these in molecular function level cancer cell lines has not been investigated. Expression levels six identified were assessed via quantitative real-time PCR (qRT-PCR) serum eligible patients. Dual-luciferase reporter assay was used determine potential target miR-106a. Cell viability apoptosis...
Background/Aims: As biomarkers, circulating tumor cells (CTCs) from solid tumors can predict metastases and prognoses, help monitor treatment efficacy. However, conventional CellSearch methods have low sensitivity to differentiated thyroid cancer (DTC) CTCs. In this study, for the first time, we used negative enriching (NE) immunofluorescence–in situ hybridization (iFISH) of chromosome 8 capture identify CTCs in DTC patients; investigated how correlate with clinicopathological factors...