A5085412582- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- CAR-T cell therapy research
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Nanocluster Synthesis and Applications
- Lanthanide and Transition Metal Complexes
University of Wisconsin–Madison
2016-2025
University of Wisconsin Carbone Cancer Center
2016-2025
National Taiwan University
2024-2025
Sun Yat-sen University
2023
Manufacturing Advocacy & Growth Network (United States)
2022
University of Electronic Science and Technology of China
2021
South China Normal University
2021
Madison Group (United States)
2014-2020
Shenzhen University
2019
Highland Community College - Illinois
2013-2017
Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of intravenously injected into animals vivo is currently unknown, an issue critical to potential clinical applications these materials. Here, using the intrinsic Raman spectroscopic signatures single-walled carbon (SWNTs), we measured blood circulation SWNTs and detect various organs tissues mice ex over a period three months. Functionalization by branched polyethylene-glycol (PEG)...
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The fluorescence intensity reached maximum at 6 h postinjection with good contrast. results reported here open up new perspectives for integrin-targeted near-infrared optical may aid cancer detection management including imaging-guided surgery.
Theranostics for in vivo cancer diagnosis and treatment generally requires well-designed nanoscale platforms with multiple integrated functionalities. In this study, we uncover that functionalized iron oxide nanoparticles (IONPs) could be self-assembled on the surface of two-dimensional MoS2 nanosheets via sulfur chemistry, forming MoS2-IO nanocomposites, which are then modified two types polyethylene glycol (PEG) to acquire enhanced stability physiological environments. Interestingly, 64Cu,...
To date, the in vivo imaging of quantum dots (QDs) has been mostly qualitative or semiquantitative. The development a dual-function PET/near-infrared fluorescence (NIRF) probe can allow for accurate assessment pharmacokinetics and tumor-targeting efficacy QDs.A QD with an amine-functionalized surface was modified RGD peptides 1,4,7,10-tetraazacyclodocecane-N,N',N'',N'''-tetraacetic acid (DOTA) chelators integrin alpha(v)beta(3)-targeted PET/NIRF imaging. A cell-binding assay cell staining...
Photodynamic therapy (PDT), a noninvasive cancer therapeutic method triggered by light, would lead to severe tumor hypoxia after treatment. Utilizing hypoxia-activated prodrug, AQ4N, which only shows toxicity cells under hypoxic environment, herein, multipurpose liposome is prepared encapsulating hydrophilic AQ4N and hydrophobic hexadecylamine conjugated chlorin e6 (hCe6), photosensitizer, into its aqueous cavity bilayer, respectively. After chelating 64Cu isotope with Ce6, the obtained...
Since the first use of biocompatible mesoporous silica (mSiO2) nanoparticles as drug delivery vehicles, in vivo tumor targeted imaging and enhanced anticancer has remained a major challenge. In this work, we describe development functionalized mSiO2 for actively positron emission tomography (PET) 4T1 murine breast tumor-bearing mice. Our structural design involves synthesis, surface functionalization with thiol groups, PEGylation, TRC105 antibody (specific CD105/endoglin) conjugation,...
Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective facilitating skin recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient bandage accelerated healing. On bandage, alternating discrete field generated wearable nanogenerator converting mechanical displacement from movements into electricity. Rat studies demonstrated rapid closure of full-thickness...
Herein we demonstrate that nanographene can be specifically directed to the tumor neovasculature in vivo through targeting of CD105 (i.e., endoglin), a vascular marker for angiogenesis. The covalently functionalized oxide (GO) exhibited excellent stability and target specificity. Pharmacokinetics efficacy GO conjugates were investigated with serial noninvasive positron emission tomography imaging biodistribution studies, which validated by vitro, vivo, ex experiments. incorporation an active...
In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted system that is battery-free and spontaneously responsive to stomach movement. The comprises a flexible biocompatible nanogenerator attached on the surface of stomach. It generates biphasic electric pulses peristalsis signals generated by this device can stimulate vagal afferent fibers reduce achieve weight control. This strategy successfully demonstrated rat...