A5091733017- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- GABA and Rice Research
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Rice Cultivation and Yield Improvement
- Brain Metastases and Treatment
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Head and Neck Surgical Oncology
- Diabetes Management and Research
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Neuroinflammation and Neurodegeneration Mechanisms
- Galectins and Cancer Biology
- Internet Traffic Analysis and Secure E-voting
- Microbial Metabolism and Applications
- Blockchain Technology Applications and Security
- Ubiquitin and proteasome pathways
- Vascular Malformations Diagnosis and Treatment
Fudan University
2018-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2025
Shanghai Clinical Research Center
2022-2025
Huashan Hospital
2018-2025
State Key Laboratory of Medical Neurobiology
2024
Zhejiang A & F University
2021
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function IRG1/ITA has been established in multiple pathogen models, but very little is known cancer. Here, we show IRG1 expressed tumor-associated macrophages (TAMs) both human and mouse tumors. Mechanistically, tumor cells induce Irg1 expression by activating NF-κB pathway, ITA produced ACOD1 inhibits TET DNA dioxygenases to dampen...
The development and performance of two mass spectrometry (MS) workflows for the intraoperative diagnosis isocitrate dehydrogenase (IDH) mutations in glioma is implemented by independent teams at Mayo Clinic, Jacksonville, Huashan Hospital, Shanghai. infiltrative nature gliomas makes rapid necessary to guide extent surgical resection central nervous system (CNS) tumors. combination tissue biopsy MS analysis used here satisfies this requirement. key feature both described methods use tandem...
Tumor organoids are important tools for cancer research, but current models have drawbacks that limit their applications predicting response to therapy. Here, we developed a fast, efficient, and complex culture system (IPTO, individualized patient tumor organoid) accurately recapitulates the cellular molecular pathology of human brain tumors. Patient-derived explants were cultured in induced pluripotent stem cell (iPSC)-derived cerebral organoids, thus enabling wide range tumors central...
Transmembrane protein 64 (TMEM64), a member of the family transmembrane protein, is an α-helical membrane protein. Its precise role in various types tumors, including glioma, unclear. This study used immunohistochemical (IHC) staining, western blotting, and quantitative reverse transcription polymerase chain reaction (qRT-PCR) techniques to show that TMEM64 expression was significantly higher glioma cells tissues compared normal tissues, respectively. Additionally, correlation between high...
The double-stranded RNA-binding protein Staufen1 (STAU1) regulates a variety of physiological and pathological events via mediating RNA metabolism. STAU1 overabundance was observed in tissues from mouse models fibroblasts patients with neurodegenerative diseases, accompanied by enhanced mTOR signaling impaired autophagic flux, while the underlying mechanism remains elusive. Here, we find that endogenous forms dynamic cytoplasmic condensate normal tumor cell lines, as well Huntington’s...
Gliomas exhibit high heterogeneity and poor prognosis. Despite substantial progress has been made at the genomic transcriptomic levels, comprehensive proteomic characterization its implications remain largely unexplored. In this study, we perform profiling of gliomas using 343 formalin-fixed paraffin-embedded tumor samples 53 normal-appearing brain from 188 patients, integrating these data with panel information clinical outcomes. The analysis uncovers two distinct subgroups: Subgroup 1,...
Highlights•TKT attenuates the chemosensitivity in glioma independent of catalytic activity•Chemotherapeutic drugs promote TKT's nuclear translocation cells•TKT interacts with XRN2 to regulate resolution and removal R-loopsSummaryGlioblastoma (GBM) is a highly lethal malignant brain tumor poor survival rates, chemoresistance poses significant challenge treatment patients GBM. Here, we show that transketolase (TKT), metabolic enzyme pentose phosphate pathway (PPP), chemotherapy sensitivity...
Brain metastasis is the most devasting form of lung cancer. Recent studies highlight significant differences in tumor microenvironment (TME) between cancer brain (LCBM) and primary cancer, which contribute significantly to progression drug resistance. Cancer-associated fibroblasts (CAFs) are major component pro-tumor TME with high plasticity. However, lineage composition function CAFs LCBM remain elusive. By reanalyzing single-cell RNA sequencing (scRNA-seq) data (GSE131907) from patients...
The Mediterranean diet (MD) has shown promising results in preventing type 2 diabetes, particularly and European populations. However, the applicability of these benefits to non-Mediterranean populations is unclear, with contradictory findings literature. In this study, we included 12,575 participants without diabetes at baseline from China Health Nutrition Survey (CHNS). Dietary intake was measured by three consecutive 24-h dietary recalls. adherence (MDA) a score scale that nine components...
Deep-seated brain tumors pose a distinctive neurosurgical challenge, as frequently surrounded by eloquent structures. 3D exoscope represents potential new paradigm for mini-invasive neurosurgery, which shows advantage during the procedure this kind of challenging cases. Utilizing combination exoscopes and endoscopes, we successfully removed left tentorial meningioma in patient via subtemporal keyhole approach. Combination endoscope has advantages precise tissue identification, minimized...
Juglone has been extensively reported as a natural antitumor pigment. However, it is easy to be oxidized due active hydroxy in the quinone. Here, we designed some new juglone derivatives, was replaced by methyl (D1), allyl (D2), butyl (D3), and benzyl (D4) groups. Nuclear magnetic resonance spectra mass spectrometry were applied confirm derivatives oxidative products of juglone. U87 U251 cell lines used for tests vitro, primary human glioblastoma cells vivo experiments. The CCK8 EdU assay...
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, function beyond immune regulation has been widely studied. However, expression preference and mechanism underlying in different subtypes gliomas rarely understood. We show here that significantly decreased IDH-mutated cultured IDH1-R132H glioma cells. Accumulation 2-HG leads to remarkable downregulation activity mutant responsible for reduction Inhibition autophagy by inhibitors...
DDX60 , an interferon (IFN)-inducible gene, plays a promotional role in many tumors. However, its function glioma remains unknown. In this study, bioinformatic analysis (TCGA, CGGA, Rembrandt) illustrated the upregulation and prognostic value of gliomas. Immunohistochemical staining clinical samples (n = 49) validated expression is higher gliomas than normal tissue 20, P < 0.0001). It also could be included nomogram as parameter to predict 3- 5-year survival risk (C-index 0.86). The...
Background: The pineal region tumors are challenging for neurosurgeons and can lead to secondary hydrocephalus. advent of the exoscope has provided clinical interventions with high image quality an ergonomic system tumor operations. In this study, we describe exoscopic approach used facilitate surgical resection relieve Materials Methods: retrospective cohort consecutively reviewed radiological data 25 patients lesions who underwent three-dimensional at a single center. Results: patient...
A fertility obstacle exists in hybrid production between distant related species, particularly from different genera. In the present study, by using tissue culture and chromosome doubling technology, radish (Raphanus sativus L.) kohlrabi (Brassica oleracea L. var. caulorapa DC.) were subjected to intergeneric hybridisation. Through a combination of bud pollination ovary rescue five putative hybrids obtained, three which identified as true with acquisition frequency 0.85%. After propagation...
Abstract Weedy rice (WR, Oryza sativa L. f. spontanea ) is a noxious agricultural weed, infesting fields worldwide and causing tremendous yield losses of cultivated rice. However, little known about the relationship between genetic diversity distribution WR populations across wide latitudinal gradient, in addition to its reasons for differentiation. To determine differentiation, we analyzed 20 collected from geographic ranges rice‐planting regions Northeast, Jiangsu, Guangdong provinces...
Abstract Background The molecular profiling of glioblastoma (GBM) based on transcriptomic analysis could provide precise treatment and prognosis. However, current subtyping (classic, mesenchymal, neural, proneural) is time-consuming cost-intensive hindering its clinical application. A simple efficient method for classification was imperative. Methods In this study, to simplify GBM more efficiently, we applied a random forest algorithm conduct 26 genes as cluster featured with hub genes,...