Abstract Research areas such as proteomics and metabolomics are driving the demand for mass spectrometers that have high performance but modest power requirements, size, cost. This paper describes an instrument, Orbitrap, based on a new type of analyzer invented by Makarov. The Orbitrap operates radially trapping ions about central spindle electrode. An outer barrel‐like electrode is coaxial with inner spindlelike mass/charge values measured from frequency harmonic ion oscillations, along...

Complex mixtures can be ionized directly from paper for quantitative mass spectrometric analysis of trace components. Prior separations are an option. Detailed facts importance to specialist readers published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should...

A low-temperature plasma (LTP) probe has been developed for ambient desorption ionization. An ac electric field is used to induce a dielectric barrier discharge through use of specially designed electrode configuration. The extracted from the where it interacts directly with sample being analyzed, desorbing and ionizing surface molecules in environment. This allows experiments be performed without damage or underlying substrate and, case biological analysis on skin surfaces, electrical shock...

Paper spray is developed as a direct sampling ionization method for mass spectrometric analysis of complex mixtures. Ions analyte are generated by applying high voltage to paper triangle wetted with small volume (<10 μL) solution. Samples can be preloaded onto the paper, added wetting solution, or transferred from surfaces using wipe. It demonstrated that applicable wide variety compounds, including organic peptides, and proteins. Procedures dried biofluid spots applied therapeutic drug...

Images of the masses: Two-dimensional molecular imaging intact rat brain tissue under ambient conditions was achieved by using mass spectrometric technique desorption electrospray ionization (DESI). The distributions specific lipids, such as sulfatide 24:1, reveal distinctive subanatomical features (cc=corpus callosum; aca=anterior part anterior commissure) with spatial resolution less than 500 μm.

On-line droplet–droplet extraction occurs when a sample spray intersects reagent electrospray; this allows continuous analysis of trace amounts compounds directly in complex matrices including undiluted urine, milk and polluted water over extended periods time.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInstrumentation, applications, and energy deposition in quadrupole ion-trap tandem mass spectrometryJohn N. Louris, R. Graham. Cooks, John E. P. Syka, Paul Kelley, George C. Stafford, F. J. ToddCite this: Anal. Chem. 1987, 59, 13, 1677–1685Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/ac00140a021https://doi.org/10.1021/ac00140a021research-articleACS...

Ambient ionization methods for MS enable direct, high-throughput measurements of samples in the open air. Here, we report on one such method, desorption electrospray (DESI), which is coupled to a linear ion trap mass spectrometer and used record spatial intensity distribution drug directly from histological sections brain, lung, kidney, testis without prior chemical treatment. DESI imaging provided identification clozapine after an oral dose 50 mg/kg by: i ) measuring abundance intact at m /...

Desorption electrospray ionization (DESI) mass spectrometry is used to detect trace amounts of explosives present on a variety ambient surfaces in 5-second analysis times without any sample preparation.

Various organic reactions, including important synthetic reactions involving C-C, C-N, and C-O bond formation as well of biomolecules, are accelerated when the reagents present in sprayed or levitated microdroplets thin films. The reaction rates increase by orders magnitude with decreasing droplet size film thickness. effect is associated at solution-air interface. A key factor partial solvation interface, which reduces critical energy for reaction. This phenomenon intrinsic interest...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton affinities from dissociations of proton-bound dimersS. A. McLuckey, D. Cameron, and R. G. CooksCite this: J. Am. Chem. Soc. 1981, 103, 6, 1313–1317Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ja00396a001https://doi.org/10.1021/ja00396a001research-articleACS PublicationsRequest reuse permissionsArticle Views892Altmetric-Citations386LEARN...

Latent fingerprints (LFPs) potentially contain more forensic information than the simple identification of subject; they may evidence contacts with explosives or substances abuse. Chemical can also be useful in resolving overlapping LFPs from different individuals. We used desorption electrospray ionization mass spectrometry an imaging mode to record compound-specific chemical fingerprints.

Functional group derivatization reactions occur in the course of microdroplet/surface collisions ambient ionization process desorption electrospray (DESI). The unique environment microdroplet causes rate enhancements as much several orders magnitude typical bimolecular that proceed through either cationic or anionic intermediates. evaporating charged differs from bulk: (i) pH solution moves towards extremes, (ii) concentrations reagents increase, (iii) relative surface area increases and...

Desorption electrospray ionization (DESI), an ambient mass spectrometry technique, is used for trace detection of the explosives trinitrohexahydro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), 2,4,6-trinitrotoluene (TNT), Pentaerythritol tetranitrate (PETN), and their plastic compositions (Composition C-4, Semtex-H, Detasheet) directly from a wide variety surfaces (metal, plastic, paper, polymer) without sample preparation or pretreatment. Analysis performed...

Desorption electrospray ionization (DESI) allows mass spectrometry to be used for on-line high-throughput monitoring of pharmaceutical samples in the ambient environment, without prior sample preparation. Positive and negative ion DESI are characterize active ingredients formulated as tablets, ointments, liquids. Compounds a wide variety chemical types detected these complex matrices. The effects on analytical performance operating parameters, including high voltage, heated capillary...

A droplet pickup and other mechanisms have been suggested for the ionization of biomolecules like peptides proteins by desorption electrospray ionization. To verify this hypothesis phase Doppler particle analysis was used to study sizes velocities droplets involved in DESI. It found that impacting typically 120 m/s average diameters 2-4 microm. Small differences sprayer construction influence operating conditions at which these dimensions are produced. Under conditions, kinetic energy per...