A5101726929- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Pediatric Hepatobiliary Diseases and Treatments
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- RNA Research and Splicing
- Liver Diseases and Immunity
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Pharmacological Effects and Toxicity Studies
- T-cell and B-cell Immunology
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- Reproductive System and Pregnancy
Fudan University
2016-2025
Huashan Hospital
2016-2025
Xian Yang Central Hospital
2014
Shanghai Changzheng Hospital
2009-2013
Gorgias Press (United States)
2013
Second Military Medical University
2009-2011
The University of Texas MD Anderson Cancer Center
2007-2008
Rockefeller University
1999-2001
Although microRNAs (miRNAs) are key regulators of gene expression in normal human physiology and disease, transcriptional regulation miRNAs is poorly understood, because most miRNA promoters have not yet been characterized. We identified the proximal 175 by combining nucleosome mapping with chromatin signatures for promoters. observe that one-third intronic transcription initiation regions independent from their host present a list RNA polymerase II- III-occupied miRNAs. Nucleosome linker...
In our in-depth analysis carried out by the Illumina Solexa massive parallel signature sequencing, microRNA-99a (miR-99a) was found to be sixth abundant microRNA in miRNome of normal human liver but markedly down-regulated hepatocellular carcinoma (HCC). Compelling evidence has suggested important roles microRNAs HCC development. However, biological function miR-99a deregulation remains unknown. this study, we that remarkably decreased tissues and cell lines. Importantly, lower expression...
Abstract Tertiary lymphoid structure (TLS) can predict the prognosis and sensitivity of tumors to immune checkpoint inhibitors (ICIs) therapy, whether it be noninvasively predicted by radiomics in hepatocellular carcinoma with liver transplantation (HCC‐LT) has not been explored. In this study, is found that intra‐tumoral TLS abundance significantly correlated recurrence‐free survival (RFS) overall (OS). Tumor tissues are characterized inflammatory signatures high infiltration antitumor...
A yeast two-hybrid assay has identified an androgen-dependent interaction of androgen receptor (AR) with amino-terminal enhancer split (AES), a member the highly conserved Groucho/TLE family corepressors. Full-length AR, as well N-terminal fragment showed direct interactions AES in vitro protein-protein assays. specifically inhibited AR-mediated transcription well-defined cell-free system and interacted basal factor (TFIIE) HeLa nuclear extract. These observations implicate selective...
The cooperative roles of SENP1 and UBE2T in development progression hepatocellular carcinoma (HCC) are still unknown.The expression levels were evaluated clinical specimens HCC cells.The relationship between clinicopathological features analyzed.We constructed the HepG2-SENP1 knockout cell model explored functions development.UBE2T was confirmed as a novel deSUMOylation target SENP1.Upregulation observed tissues most hepatoma lines, their proved to be positively related.Knockout resulted...
Hepatocellular carcinoma (HCC) accounts for more than 80% of primary liver cancers and is one the leading causes cancer-related death in many countries. Cancer cell-derived exosomes are shown to mediate communications between cancer cells microenvironment, promoting tumorigenesis. Hedgehog signaling pathway plays important roles development HCC.Exosomes were isolated from culture medium HCC cell lines PLC/PRF/5 MHCC-97H found promote growth measured with proliferation colony formation assay....
Liver transplantation (LT) is a highly curative therapy for patients with hepatocellular carcinoma (HCC). However, due to the shortage of donor livers and rapid progression HCC, majority are dropped out from waitlist. Recently, immunotherapy has shown great promise in treatment advanced HCC. use limited LT mainly potentially increasing risk graft rejection. One main challenges researchers protection an immunotherapy-boosted immune response mounted by host. Besides, safety, availability,...
ABSTRACT Hepatic ischemia/reperfusion injury (IRI) commonly complicates liver transplantation (LT). However, the precise mechanisms underlying hepatic IRI remain incompletely understood. We acquired single‐cell RNA sequencing (scRNA‐seq) and transcriptome data of LT patients from GEO database. Employing scRNA‐seq, we delved into interplay between non‐immune immune cells in IRI, pinpointing genes exhibiting altered expression patterns. Integrating insights gleaned scRNA‐seq datasets, deepened...
<title>Abstract</title> Background Despite increased use, the impact of elder donors on outcomes liver transplantation remains controversial, particularly with regard to postoperative complications. Methods Retrospective data adult deceased between August 1, 2017 November 30, 2023 were collected. The aim was compare survival as well complications recipients elderly (≥ 60 years) younger (< years). Results Out a total 950 transplants, 201 and 749 donors. No difference in overall or...
Congenital hepatic fibrosis is a hereditary fibropolycystic disease caused by ductal plate malformation. It characterized portal hypertension, but the manifestations, management, and outcome vary in children adults. To raise awareness of medical staff, we have comprehensively compared clinical features congenital between We retrospectively enrolled all patients diagnosed with at Huashan Hospital from August 2015 to 2017 analyzed their familial, clinical, laboratory, imaging, treatment,...
Hepatic fibrosis (HF) is the typical response to chronic liver disease and characterized by deposition of abundant extracellular matrix. The aim present study was investigate protective effect resveratrol (RSV) in a CCl4-induced rat model HF. We demonstrate that administration RSV effectively improves function ameliorates reducing collagen reversing expression COL1A1 PPAR-γ. Treatment efficacy could be attributed reversed epithelial-mesenchymal transition progress with upregulated E-cadherin...
The pathogenesis of liver in patients with hepatitis B virus-associated acute chronic failure (HBV-ACLF) remains largely unknown. We aimed to elucidate the molecular mechanism underlying HBV-ACLF by using multiple approaches including transcriptome analysis. performed transcriptomic sequencing analysis on (n = 6), cirrhosis 6) and normal control 5), then explored potential specimen from another 48 subjects further validated cellular mechanisms THP-1 cells. RNA-sequencing data indicated that,...
A wave of Omicron infections rapidly emerged in China 2022, but large-scale data concerning the safety profile vaccines and Coronavirus disease 2019 (COVID-19) infection features liver transplant (LT) recipients have not been collected. Therefore, aim this study was to assess protectiveness inactivated LT patients against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infections. multi-centre retrospective conducted a cohort with history transplantation. total 1881...