A5103015041- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Energetic Materials and Combustion
- Multicomponent Synthesis of Heterocycles
- Cell Adhesion Molecules Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Thermal and Kinetic Analysis
- Cancer therapeutics and mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- FOXO transcription factor regulation
- Galectins and Cancer Biology
- Ionic liquids properties and applications
- Angiogenesis and VEGF in Cancer
- HER2/EGFR in Cancer Research
Huashan Hospital
2013-2025
Fudan University
2013-2025
Tianjin University of Traditional Chinese Medicine
2024
Hubei University
2024
Capital Medical University
2021
Shanghai Medical College of Fudan University
1996-2014
Nanjing University of Science and Technology
2006-2013
Shanghai Chest Hospital
2007
Xiaomi (China)
2007
Cancer Institute (WIA)
1996
Brain metastasis (BM) is the primary contributor to mortality in non-small cell lung cancer (NSCLC) patients. Although findings of NSCLC genetic sequencing studies suggest potential for personalizing therapeutic approaches, profiles and underlying mechanisms BM progression remain poorly understood. Here, we investigated brain metastases from six patients with tumors corresponding samples via whole exome targeted panel sequencing. We have demonstrated considerable heterogeneity between...
Growing evidence indicates that phosphoserine phosphatase (PSPH) is up-regulated and correlates with prognosis in multiple types of cancer. However, little known about the roles PSPH NSCLC. Thus, aim present study was to demonstrate expression human NSCLC reveal its biological functions underlying mechanisms. qRT-PCR, western blot immunohistochemistry were used assess patient specimens cell lines. The migration invasion determined using trans-well wound-healing assays. Cell proliferation...
The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. goal of the current study was to explore whether tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines paired cerebrospinal fluid (CSF) and plasma samples from lung adenocarcinoma (LAC) patients with leptomeningeal metastases (LM).Paired CSF cell free DNA (cfDNA), cells, formalin-fixed paraffin-embedded (FFPE) primary tumors were collected 29 LAC LM...
Due to the complicated metabolic and regulatory networks of l-serine biosynthesis degradation, microbial cell factories for production using non-model microorganisms have not been reported. In this study, a combination synthetic biology process optimization were applied in an ethanologenic bacterium Zymomonas mobilis production. By blocking degradation pathway while introducing exporter EceamA from E. coli, titer recombinant Z. was increased 15.30 mg/L 62.67 mg/L. It further 260.33 after...
Purpose This study analyzed the clinicopathologic characteristics of typical medullary breast carcinoma (TMBC) in a cohort Chinese patients. Methods We conducted retrospective review clinical data including general information, pathologic results, treatment regimens, and patient survival cases TMBC diagnosed between February 2004 April 2011. Results A total 117 patients were enrolled, with median age 52 years (range, 28∼92 years). Stage I II disease accounted for 31.6% 61.6% cases,...
Abstract The monocytic MDSC (M‐ ) is one of the major types s, which play important roles in suppression antitumor immunity. However, mechanisms underlying how M‐ s so heavily accumulate patients with cancer are still poorly understood. purpose this study was to identify mi RNA that regulate proliferation and differentiation s. Microarray analysis performed differentially expressed between tumor‐induced ( TM ‐ s) their counterparts from tumor‐free mice. target genes myeloid cells were...
The UGT1A1*28 polymorphism, although closely linked with CPT-11-related adverse effects, cannot be used alone to guide individualized treatment decisions. However, CPT-11 dosage can adjusted according measured SN-38 pharmacokinetics. Our study is designed investigate whether there a relationship between peak or valley concentrations and efficacy effects of CPT-11-based chemotherapy. We retrospectively studied 98 patients treated advanced colorectal cancer in various genotype groups (mainly...
Growing evidence indicates that high phosphoserine phosphatase (PSPH) expression is associated with tumor prognosis in many types of cancers. However, the role PSPH non-small cell lung cancer (NSCLC) unclear. The purpose this study was to investigate clinical significance NSCLC.One hundred forty-three patients histologically confirmed NSCLC who underwent surgery were included. Quantitative real-time PCR and Western blot used assess paired corresponding adjacent non-tumorous tissues. invasion...