A5102027923- Bladder and Urothelial Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Pleural and Pulmonary Diseases
- Urologic and reproductive health conditions
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Sexual function and dysfunction studies
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- GDF15 and Related Biomarkers
- Pediatric Urology and Nephrology Studies
- Angiogenesis and VEGF in Cancer
- Prostate Cancer Diagnosis and Treatment
Third Xiangya Hospital
2016-2025
Central South University
2016-2025
Fujian Medical University
2016-2025
Tongji University
2024
Tongji Hospital
2024
Wenzhou Medical University
2023-2024
Xuzhou Central Hospital
2014-2023
Shanghai Chest Hospital
2014-2023
Shanghai Jiao Tong University
2009-2023
Xuzhou Medical College
2013-2023
The overall response of cisplatin-based chemotherapy in bladder urothelial carcinoma (BUC) remains unsatisfactory due to the complex pathological subtypes, genomic difference, and drug resistance. genes that associated with cisplatin resistance remain unclear. Herein, we aimed identify BUC. EXPERIMENTAL DESIGN: cytotoxicity was evaluated six cancer cell lines compare their responses cisplatin. T24 cells exhibited lowest sensitivity therefore selected explore mechanisms We performed...
Abstract Chemoresistance has been a major challenge in advanced gastric cancer (GC) therapy. Exosomal transfer of oncogenic miRNAs implicates important effects mediating recipient cell chemoresistance by transmitting active molecules. In this study, we found that microRNA‐500a‐3p was highly expressed cisplatin (DDP) resistant GC cells (MGC803/DDP and MKN45/DDP) their secreted exosomes than the corresponding parental cells. MGC803/DDP‐derived enhance DDP resistance stemness properties MGC803...
Abstract Background Recurrent bladder cancer is the most common type of urinary tract malignancy; nevertheless, mechanistic basis for its recurrence uncertain. Innovative technologies such as single‐cell transcriptomics and spatial (ST) offer new avenues studying recurrent tumour progression at level while preserving data. Method This study integrated RNA (scRNA) sequencing ST profiling to examine microenvironment (TME) six tissues (three from primary tumours three tumours). Findings scRNA...
The aim of the present study was to evaluate diagnostic value ImmunoCyt test compared with urine cytology in detecting bladder cancer. A systematic literature search performed locate all publications reporting on accuracy for Data were extracted from 2x2 tables or calculated reported data. Collected data meta-analyzed sensitivity, specificity, positive likelihood ratio (LR), negative LR, odds (DOR), and summary receiver operator characteristic (sROC) curve analysis. We applied Meta-DiSc 1.4...
With the rapid development of surgical technics and instruments, more locally advanced non-small cell lung cancer (NSCLC) patients are being treated by minimally invasive surgery (MIS), including video-assisted thoracoscopic (VATS) robotic-assisted thoracic (RATS). The aim this retrospective study was to compare perioperative long-term outcomes who underwent lobectomy these two approaches.We performed a review prospectively collected database our hospital identify with clinical stage...
Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common of urinary system. In current study, we investigated function mechanisms Neuropilin-1 (NRP1), co-receptor for vascular endothelial growth factor, in BC pathogenesis progression. The expression NRP1 was evaluated using data extracted from GEO HPA databases examined cell lines. effect on proliferation, apoptosis, angiogenesis, migration, invasion cells were validated after knockdown. After identifying...
Background: This aim of this study was to compare three approaches extended thymectomy for the treatment early-stage thymomas, which included robot-assisted thoracic surgery (RATS), video-assisted (VATS), and median sternotomy (MS) perioperative parameters. Methods: A retrospective conducted on 123 patients with early stage thymomas at Shanghai Chest Hospital who underwent between February 2009 August 2014. Among them, MS performed 37 patients, VATS 35 RATS 51 patients. series outcome...
Robotic thoracoscopic surgery was first done in mainland China 2009 and has gained popularity the past few years. Here, we present largest Chinese series of robotic lobectomy for early-stage non-small cell lung cancer (NSCLC) to date. We aimed compare perioperative outcomes our three-arm robotic-assisted (RAL3) video-assisted (VAL) p-stage I NSCLC report approach anatomic lobar resections center.We retrospectively collected analyzed data 1075 stage patients who underwent minimally invasive...
Abstract Background Solanum nigrum L. decoction has been used as a folklore medicine in China to prevent the postoperative recurrence of bladder cancer (BC). However, there are no previous pharmacological studies on protective mechanisms this activity plant. Thus, study aimed perform systematic analysis and predict potential action underlying S. BC based network pharmacology. Methods Based pharmacology, active ingredients corresponding targets were identified using Traditional Chinese...
Solasonine, a steroidal alkaloid extracted from Solanum nigrum L., has been found to exert inhibitory effect on cancers. However, the underlying anticancer mechanisms of solasonine, particularly in urinary bladder cancer (BC), remain unclear. In this study, we identified potential targets and biological functions associated with solasonine activity using bioinformatics approach. Ingenuity pathway analysis revealed that neuropilin-1 (NRP1) other signaling pathways, such as PI3K/AKT ERK/MAPK...
Robotic-assisted thoracic surgery (RATS) has been widely used in the treatment of lung cancer. The perioperative outcomes right upper lobectomy (RUL) using RATS and video-assisted (VATS) were retrospectively investigated compared. We aimed to summarize a single-center experience 4-port unidirectional VATS RUL, discuss safety essentials surgery.We analyzed 685 with non-small cell cancer (NSCLC) patients who underwent minimally invasive RUL our center by same surgical group from January 2015...
To observe and explore the effect of metformin on migration proliferation bladder cancer T24 5637 cells in vitro.Bladder cell lines were cultured vitro, divided into group A (blank control group) B (metformin group: 5, 10, 15, 20 mmol/L); both groups plated 6-well plates at same time. Culture 24-well was used for wound healing assays 96-well Transwell invasion, Cell Counting Kit-8 experiments. We observed detected ability each 48 h, calculated area survival rate. Flow cytometry to detect...
This study aimed to determine whether the enhancer of rudimentary homolog (ERH) gene regulates cell migration and invasion in human bladder urothelial carcinoma (BUC) T24 cells underlying mechanism. First, we knocked down ERH BUC 5637 by shRNA then used wound healing scratch assays, transwell chamber experiments nude mouse tail vein transfer assays ability after was down. Moreover, expression profiling chip analysis further functional explore possible mechanism through which knockdown...
Bladder cancer (BCa) is a common malignancy in the urinary system. Ras-related protein Rab-27A (RAB27A) and Rab-27B (RAB27B) have been verified to be closely related development of many tumors. Since role both RAB27A RAB27B BCa not reported, we intended explore function mechanism development. Reverse transcription quantitative polymerase chain reaction revealed that RAB27A/B showed high expression tissues cells. Cell counting kit-8, wound healing Transwell assays as well western blot...
Current biochemical approaches have only identified the most well-characterized kinases for a tiny fraction of phosphoproteome, and functional assignments phosphosites are almost negligible. Herein, we analyze substrate preference catalyzed by specific kinase present novel integrated deep neural network model named FuncPhos-SEQ assignment human proteome-level phosphosites. incorporates phosphosite motif information from protein sequence using multiple convolutional (CNN) channels features...
<title>Abstract</title> <bold>Background:</bold> The Micro Hand S surgical robot system is the first multi-cavity endoscopic in China approved for registration by National Medical Products Administration (NMPA). From 2014 to 2019, a clinical phase I study involving 81 general surgery cases was conducted at tertiary medical center evaluate long-term postoperative effects, safety, and utility of this innovative system. <bold>Methods:</bold> A cohort patients from March January 2019 followed up...
Safety and short-term efficacy of robot-assisted thoracoscopic surgery (RATS) for early-stage non-small cell lung cancer (NSCLC) have been previously proven; however, RATS N2 stage NSCLC was barely evaluated. The aim this randomized controlled trial (RCT) to explore the outcome cN2 NSCLC.Total 113 patients who were diagnosed with clinically single enrolled randomly assigned thoracotomy groups. in group treated by lobectomy mediastinal lymph node dissection using da Vinci Surgical System,...
Previous studies have focused mostly on independent effects of the stroke risk factors, whereas little attention has been paid to interactions between individual factors which may be important for prevention. We collected data related patients' demographic characteristics, history chronic diseases and lifestyle in 2258 patients with primary hypertension. Logistic regression models based odds ratio (OR) their associated 95% confidence interval (CI) were used estimate an effect homocysteine...
Our previous study demonstrated the safety and short-term efficacy of robotic-assisted thoracic surgery (RATS) in clinical N2 (c-N2) stage non-small cell lung cancer (NSCLC) patients. From this, present was devised, which follow-up time sample size were both extended to explore long-term potential benefit survival RATS compared with lobectomy c-N2 NSCLC patients.Patients NSCLS randomly assigned a 1:1 ratio accept operation through thoracotomy or RATS. The da Vinci Surgical System (Si/Xi)...